A kind of preparation method of dendrobium instant freeze-dried block

A dendrobium and freeze-drying technology, which is applied in the direction of freeze-drying transportation, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of less dissolution of active ingredients, inconvenient taking, and influence on taking, and achieve Broad market application prospects, fast reconstitution speed, excellent reconstitution and instant effect

Active Publication Date: 2022-02-08
厦门涌泉科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both Xianpin and Fengdou have disadvantages such as inconvenient administration, less dissolution of active ingredients and low bioavailability
Dendrobium contains a large amount of mucopolysaccharide and cellulose components, which are not easy to disperse, and it is easy to stick into agglomerates when mixed with boiling water, which affects its intake.
CN101700361A discloses a kind of Dendrobium candidum instant powder and preparation method thereof, said fresh Dendrobium candidum is added with water to extract juice, then freeze-dried or spray-dried and then added auxiliary materials to prepare Dendrobium candidum instant powder, the method prepares Dendrobium instant powder and its resolubility Low, and bubbling, peeling, and fracture have occurred during the freeze-drying process, which affects its freeze-drying efficiency
CN104056069A discloses a preparation method of a dendrobium broken wall preparation, the broken wall of the dendrobium is crushed and then granulated and dried to obtain a dendrobium broken wall preparation. The preparation is easily sticky when mixed with boiled water, and the solubility is not good
CN104623312A discloses a kind of dendrobium instant powder, its preparation method and application. The fresh dendrobium candidum is homogenized with water, sprayed and dried with auxiliary materials and then granulated to obtain dendrobium instant powder. The higher the volatility of heat-sensitive substances and the loss of active ingredients, the color will change, and the solubility in water is not good enough. In order to keep the original volume and shape of the product after drying, it can be dissolved quickly and completely after adding water. , in the drying process, it is often necessary to add a certain amount of excipients to maintain the porous solid structure of the freeze-dried product

Method used

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  • A kind of preparation method of dendrobium instant freeze-dried block
  • A kind of preparation method of dendrobium instant freeze-dried block
  • A kind of preparation method of dendrobium instant freeze-dried block

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Remove the leaves from the fresh Dendrobium raw materials, and cut into small sections of 1-2 cm after cleaning;

[0031] (2) above-mentioned small section is placed in wall breaking device, mixes with the distilled water of 10 times of volumes, breaks wall 1min with the rotating speed of 30000rpm;

[0032] (3) the material of step (2) gained adopts three-legged centrifugal filtration, and its rotating speed is 500~800rpm;

[0033] (4) the solid obtained in step (3) is placed in a high-speed dispersing device, and is dispersed 3min with a rotating speed of 8000rpm;

[0034] (5) the material obtained in step (4) is placed in a high-pressure homogenization device to perform high-pressure homogenization twice, and each high-pressure homogenization includes a first homogenization and a second homogenization in turn, wherein the pressure of the first homogenization is 400Bar, and the pressure of the second homogenization is 1500Bar;

[0035] (6) in the material of step...

Embodiment 2

[0042] (1) Remove the leaves from the fresh Dendrobium raw materials, and cut into small sections of 1-2 cm after cleaning;

[0043](2) above-mentioned small section is placed in wall breaking device, mixes with the distilled water of 10 times of volumes, breaks wall 1min with the rotating speed of 30000rpm;

[0044] (3) the material of step (2) gained adopts three-legged centrifugal filtration, and its rotating speed is 500~800rpm;

[0045] (4) the solid obtained in step (3) is placed in a high-speed dispersing device, and is dispersed 3min with a rotating speed of 8000rpm;

[0046] (5) the material obtained in step (4) is placed in a high-pressure homogenization device to perform high-pressure homogenization twice, and each high-pressure homogenization includes a first homogenization and a second homogenization in turn, wherein the pressure of the first homogenization is 400Bar, and the pressure of the second homogenization is 1500Bar;

[0047] (6) in the material of step ...

Embodiment 3

[0054] (1) Remove the leaves from the fresh Dendrobium raw materials, and cut into small sections of 1-2 cm after cleaning;

[0055] (2) above-mentioned small section is placed in wall breaking device, mixes with the distilled water of 10 times of volumes, breaks wall 1min with the rotating speed of 30000rpm;

[0056] (3) the material of step (2) gained adopts three-legged centrifugal filtration, and its rotating speed is 500~800rpm;

[0057] (4) the solid obtained in step (3) is placed in a high-speed dispersing device, and is dispersed 3min with a rotating speed of 8000rpm;

[0058] (5) the material obtained in step (4) is placed in a high-pressure homogenization device to perform high-pressure homogenization twice, and each high-pressure homogenization includes a first homogenization and a second homogenization in turn, wherein the pressure of the first homogenization is 400Bar, and the pressure of the second homogenization is 1500Bar;

[0059] (6) in the material of step...

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Abstract

The invention discloses a preparation method of dendrobium instant freeze-dried block, which comprises the following steps: (1) washing and cutting fresh dendrobium raw materials; (2) high-speed wall breaking; (3) centrifugal filtration; (4) high-speed dispersion; ( 5) high-pressure homogenization, (6) adding a lyoprotectant; (7) freeze-drying; (8) packaging. The present invention maintains the porous structure by adding excipients, and has better reconstitution and instant dissolution, uniform dispersion, and smooth mouthfeel, so that the Dendrobium instant freeze-dried block prepared by the present invention has a long shelf life, good quality, and is instant at low temperature. It has the characteristics of reconstitution and convenient portability, and has broad market application prospects.

Description

technical field [0001] The invention belongs to the technical field of food processing, and in particular relates to a preparation method of a dendrobium instant freeze-dried block. Background technique [0002] Dendrobium is a kind of herb belonging to the Orchidaceae (Orchidaceae) genus Dendrobium. The 2015 edition of the Chinese Pharmacopoeia included Dendrobium officinale and Dendrobium (source Dendrobium chinensis, Dendrobium drumstick, Dendrobium tassel). Dendrobium has the effect of "mainly injuring the middle, eliminating paralysis, lowering the qi, nourishing the five internal organs to gain weight, strengthening the yin, thickening the stomach and stomach for a long time, lightening the body and prolonging the life". As one of the traditional precious Chinese medicinal materials, Dendrobium has the reputation of "the first of the nine Chinese immortal herbs" among the people, and it is a precious traditional Chinese medicine with a variety of biologically active s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8984A61K9/19A61K47/26A61P39/06A61P37/04A61P3/10A61P39/00A61P35/00A61P1/14A23L33/00
CPCA61K36/8984A61K9/19A61K47/26A61P39/06A61P37/04A61P3/10A61P39/00A61P35/00A61P1/14A23L33/00A23V2002/00A61K2236/15A61K2236/17A23V2200/302A23V2200/324A23V2200/308A23V2200/328A23V2200/32
Inventor 汤须崇黄志宏黄永恒赖鹭挺苏兴添郑丹玉赵丽茹
Owner 厦门涌泉科技有限公司
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