A device for continuous preparation of 2,6-dihydroxybenzaldehyde and its application
A technology for chemicalization reaction of dihydroxybenzaldehyde, which is applied in the field of continuous preparation of 2,6-dihydroxybenzaldehyde, can solve the problems of low production efficiency and high cost of the preparation process, and achieve post-processing cost saving and production efficiency improvement , the effect of improving production efficiency
Active Publication Date: 2021-09-07
ASYMCHEM LAB FUXIN
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[0008] The main purpose of the present invention is to provide a device for continuous preparation of 2,6-dihydroxybenzaldehyde and its application, so as to solve the problems of low production efficiency and high cost of the 2,6-dihydroxybenzaldehyde preparation process in the prior art
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[0028] It should be noted that, in the case of no conflict, the embodiments in the present application and the features in the embodiments can be combined with each other. The present invention will be described in detail below with reference to the accompanying drawings and examples.
[0029] As analyzed in the background technology of the present application, the production efficiency of the prior art 2,6-dihydroxybenzaldehyde preparation process is low and the cost is high. In order to solve this problem, the application provides a continuous preparation of 2,6-dihydroxybenzaldehyde Formaldehyde device and its application.
[0030] In a typical implementation of the present application, a device for continuous preparation of 2,6-dihydroxybenzaldehyde is provided, such as figure 1As shown, the device includes a first continuous reaction unit 10 for hydroxyl protection reaction, a second continuous reaction unit 20 for lithiation and formylation and a third continuous reacti...
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The invention provides a device for continuously preparing 2,6-dihydroxybenzaldehyde and its application. The device comprises a first continuous reaction unit for hydroxyl protection reaction, a second continuous reaction unit for lithiation formylation and a third continuous reaction unit for deprotection reaction in series, the third The continuous reaction unit includes: a first columnar continuous reactor connected to the second continuous reaction unit for deprotection of the lithiated aldylation product and performing liquid separation to obtain a compound containing 2,6-dihydroxybenzaldehyde organic and aqueous phases. Since the device is applied to the preparation of 2,6-dihydroxybenzaldehyde, the reaction time is shortened and no intermediate purification treatment is required, so compared with the batch process, it can greatly save equipment costs and post-treatment costs, and greatly improve production efficiency , which is more conducive to the industrialized scale-up production of 2,6-dihydroxybenzaldehyde.
Description
technical field [0001] The invention relates to the field of preparation of 2,6-dihydroxybenzaldehyde, in particular to a device for continuously preparing 2,6-dihydroxybenzaldehyde and its application. Background technique [0002] 2,6-Dihydroxybenzaldehyde is a very important intermediate in organic synthesis. It can be used in the fields of electrical insulation materials, ion exchange resins and dyes, and can also be used in medicine. For example, it is an important fragment of the new drug voxelotor for sickle cell disease (SCD). Its synthesis can have many routes. [0003] For example, 1,3-dimethoxybenzene is used as a raw material to obtain 2,6-dihydroxybenzaldehyde through two steps, lithiation followed by aldehyde group, and demethylation reaction. The raw materials of this route are easy to obtain, and the reaction conditions are mild, and the total yield of the two steps is about 70%. However, because Lewis acid is used for demethylation, the post-reaction treat...
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IPC IPC(8): B01J19/00B01J19/18B01J19/24B01J4/00C07C45/64C07C47/565C07C41/54C07C43/303
CPCB01J4/001B01J19/0046B01J19/18B01J19/2415C07C41/54C07C45/64C07C47/565C07C43/303Y02P20/55
Inventor 洪浩卢江平丰惜春张欣颜博
Owner ASYMCHEM LAB FUXIN