A kind of medical n-butyl ester glue with high impact resistance and high hydrophilicity

A high impact resistance, n-butyl ester technology, used in the field of medical adhesives, can solve the problems of poor impact resistance and low hydrophilic properties, and achieve the effects of excellent bonding effect, complete hemostasis, and improved water resistance.

Active Publication Date: 2022-04-22
浙江派菲特新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above deficiencies in the prior art, the present invention provides a medical n-butyl gum with high impact resistance and high hydrophilicity to solve the problem of poor impact resistance and low hydrophilicity of the existing medical n-butyl gum. technical problems, thus expanding the application range of medical n-butyl rubber in medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The medical n-butyl glue with high impact resistance and high hydrophilicity of this embodiment is composed of the following raw materials: flexible copolymer modified α-ethyl cyanoacrylate, hydrophilic modified α- n-octyl cyanoacrylate, n-butyl α-cyanoacrylate and additive package.

[0033] The mass ratio of the flexible copolymer modified ethyl α-cyanoacrylate, hydrophilic modified n-octyl α-cyanoacrylate, n-butyl α-cyanoacrylate and composite additives is 4:6:88:2 .

[0034] The flexible copolymer uses 2-carboxyethyl acrylate and butyl acrylate as monomers, and is synthesized by solution copolymerization. The degree of polymerization of the flexible copolymer is 1200.

[0035] The obtained flexible copolymer is reacted with ethyl α-cyanoacrylate by graft modification to obtain flexible copolymer modified α-ethyl cyanoacrylate, and the graft ratio of the flexible copolymer is 30 %.

[0036] The molar ratio of the 2-carboxyethyl acrylate to butyl acrylate is 2:1. ...

Embodiment 2

[0043] The medical n-butyl glue with high impact resistance and high hydrophilicity of this embodiment is composed of the following raw materials: flexible copolymer modified α-ethyl cyanoacrylate, hydrophilic modified α- n-octyl cyanoacrylate, n-butyl α-cyanoacrylate and additive package.

[0044] The mass ratio of the flexible copolymer modified ethyl α-cyanoacrylate, hydrophilic modified n-octyl α-cyanoacrylate, n-butyl α-cyanoacrylate and composite additives is 3:5:91:1 .

[0045] The flexible copolymer uses 2-carboxyethyl acrylate and butyl acrylate as monomers, and is synthesized by solution copolymerization. The degree of polymerization of the flexible copolymer is 800.

[0046]The obtained flexible copolymer is reacted with ethyl α-cyanoacrylate by graft modification to obtain flexible copolymer modified α-ethyl cyanoacrylate, and the graft ratio of the flexible polymer is 15 %.

[0047] The molar ratio of 2-carboxyethyl acrylate to butyl acrylate is 1:1.

[0048]...

Embodiment 3

[0054] The medical n-butyl glue with high impact resistance and high hydrophilicity of this embodiment is composed of the following raw materials: flexible copolymer modified α-ethyl cyanoacrylate, hydrophilic modified α- n-octyl cyanoacrylate, n-butyl α-cyanoacrylate and additive package.

[0055] The mass ratio of the flexible copolymer modified ethyl α-cyanoacrylate, hydrophilic modified n-octyl α-cyanoacrylate, n-butyl α-cyanoacrylate and composite additives is 8:2:86:4 .

[0056] The flexible copolymer uses 2-carboxyethyl acrylate and butyl acrylate as monomers, and is synthesized by solution copolymerization. The degree of polymerization of the flexible copolymer is 1500.

[0057] The obtained flexible copolymer is reacted with ethyl α-cyanoacrylate by graft modification to obtain flexible copolymer modified α-ethyl cyanoacrylate, and the graft ratio of the flexible polymer is 45 %.

[0058] The molar ratio of the 2-carboxyethyl acrylate to butyl acrylate is 3:1.

...

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Abstract

The invention discloses a medical n-butyl glue with high impact resistance and high hydrophilicity. The medical n-butyl glue is composed of the following raw materials: flexible copolymer modified α-cyanoacrylate ethyl ester, hydrophilic modified n-Octyl α-Cyanoacrylate, n-Butyl α-Cyanoacrylate and additive package. The medical n-butyl ester of the invention has excellent properties such as high impact resistance and high hydrophilicity, and meanwhile, has the advantages of stable chemical properties, no harmful substances degraded, good biocompatibility, and the like.

Description

technical field [0001] The invention relates to the technical field of medical glue, in particular to a medical n-butyl glue with high impact resistance and high hydrophilicity. Background technique [0002] In surgical operations, antibacterial and hemostasis are the basis, while suturing and tying are the two most basic operations for the repair of biological tissues. This method is not only loaded down with trivial details laboriously, and easily causes bleeding and new injury, brings more misery to the patient; The doctor also feels at a loss what to do for those large areas of bleeding that cannot find the bleeding point. If glue can be used to replace or partially replace suture, and spray glue can stop the bleeding of small blood vessels or seal the surface of cancer serosa, it will be a revolution in surgery. In the past century, people have been searching for an ideal medical treatment. Glue, and made unremitting efforts. [0003] α-cyanoacrylate adhesive is a one...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/06A61L24/00A61L24/02C08F265/06C08F220/34
CPCA61L24/06A61L24/0015A61L24/001A61L24/02A61L24/00C08F265/06A61L2400/04A61L2400/12C08L51/003C08F220/34
Inventor 林闪光叶善明金艳应磊
Owner 浙江派菲特新材料科技有限公司
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