Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Composition containing mixture of phenoxypyridine derivatives, and uses thereof

A technology of phenoxypyridine and second phenoxypyridine, which is applied in the direction of medical preparations containing active ingredients, active ingredients of heterocyclic compounds, medical raw materials derived from ferns/filamentous plants, etc., can solve the problems that need to be further improved Improvement and other issues

Inactive Publication Date: 2019-12-20
黄泳华
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Plant extracts are rich in a variety of ingredients with antibacterial activity. For example, Yang Ruoying et al. reported (Journal of Tropical Biology, 2019, 10(03): 226-230.) The extracts of plants such as horn wind, six ear bells, rattan notoginseng, Guanzhong, golden thread grass, unipedal wind, eight hundred centimeters, and piercing stone have the effect on tobacco Ralstonia solanacearum at 100mg / L and / or 500mg / L Certain antibacterial activity, but the inventors found that the antibacterial activity of the above-mentioned plant extracts to other common pathogenic bacteria needs to be further improved

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composition containing mixture of phenoxypyridine derivatives, and uses thereof
  • Composition containing mixture of phenoxypyridine derivatives, and uses thereof
  • Composition containing mixture of phenoxypyridine derivatives, and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0020] The preparation of preparation example 1 plant extract

[0021] Ultrasonic extraction method is used to dry the shade-dried plant material at 40°C, crush it, pass through a 40-mesh sieve, and put it into a ziplock bag. Before the test, 50 g of plant dry powder was weighed, and different organic solvents were added for ultrasonic extraction (as shown in Table 1), and the extraction was repeated 3 times for 60 min each time. Concentrate after filtration and store in a refrigerator at 4°C until use.

[0022] Table 1 Organic solution of ultrasonic extraction of different plant extracts

[0023] plant material Extract number Organic solvents wind PE1 ethyl acetate Fuji Sanchi PE2 n-heptane Six ear bells PE3 ethyl acetate Eight hundred percent PE4 Dichloromethane Bone style PE5 Chloroform Gastrodia PE6 acetone Guanzhong PE7 ethyl acetate broken bone PE8 ethyl acetate Guangchamasma PE9...

Embodiment 1

[0099] Embodiment 1 Preparation of oral solid preparations containing a composition of a mixture of phenoxypyridine derivatives

[0100] Prescription (1500 unit dose)

[0101]

[0102]

[0103] Preparation

[0104] Take the mixture X-Y-PEZ and auxiliary materials in the prescribed amount, and pass through a 100-mesh sieve. Take the mixture X-Y-PEZ, lactose, microcrystalline cellulose, crospovidone and starch and mix thoroughly; take the prescribed amount of hypromellose, and prepare a solution with a concentration of 10% based on hypromellose, Use lactic acid to adjust the pH to 3.0-4.0, add it to the above-mentioned mixture to make a soft material, granulate with a 16-mesh sieve, and dry at 80°C for 3-4 hours. Use a 16-mesh sieve to sieve the granules, add the prescribed amount of micropowder silica gel and magnesium stearate, mix well, fill the capsules, and obtain capsules;

[0105] Take the mixture X-Y-PEZ and auxiliary materials in the prescribed amount, and pass...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention provides a composition containing a mixture of first phenoxypyridine derivatives which are different from each other and phenoxypyridine derivatives, wherein the phenoxypyridinederivatives are specifically defined in the specification. The mixture can generate synergistic antibacterial effects with extracts of cyrtomium rhizome, jasminum lanceolarium, alocasia macrorrhiza, herba antenoronis neofiliformis, etc.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composition containing a mixture of phenoxypyridine derivatives and its application. Background technique [0002] Nosocomial infection is an important issue affecting the quality of hospital care. With the continuous development and progress of modern medical technology, antibacterial drugs are widely used, and the drug-resistant strains of clinical pathogens are increasing. Therefore, improving the antibacterial activity of existing drugs will help to improve the therapeutic effect of patients with bacterial infections. [0003] CN108939081A discloses a variety of protein tyrosine kinase inhibitors with antibacterial activity, including phenoxypyridine derivatives represented by formula I. [0004] [0005] Plant extracts are rich in a variety of ingredients with antibacterial activity. For example, Yang Ruoying et al. reported (Journal of Tropical Biology, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/44A61K31/444A61K36/12A61K36/47A61K36/63A61K36/70A61K36/83A61P31/04
CPCA61K31/44A61K31/444A61K36/12A61K36/47A61K36/63A61K36/70A61K36/83A61P31/04A61K2300/00Y02A50/30
Inventor 向飞凌云
Owner 黄泳华
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com