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Method for simultaneously separating secondary cannabidiol and cannabigerol

A technology of secondary cannabidiol and cannabidiol, which is applied in the field of cannabidiol processing and achieves the effects of good environmental protection function, no sample loss and large preparation volume

Active Publication Date: 2019-12-20
SHANGHAI TAUTO BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no related technology for the simultaneous separation of cannabidiol and cannabigerol by high-speed countercurrent chromatography

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Mix n-hexane, methyl tert-butyl ether, acetonitrile, and water in a volume ratio of 6:3:6:3 to prepare a solvent system, add it to a separatory funnel, shake it well, and let it stand for phase separation to obtain a two-phase mixture The upper and lower phases were collected separately and placed in an ultrasonic oscillator for ultrasonic degassing. Dissolve the refined oil of the full spectrum of industrial hemp in the upper phase, the upper phase is the stationary phase, and the lower phase is the mobile phase; high-speed countercurrent chromatography is used for separation, and the chromatographic conditions are set as: forward rotation, speed 800rpm; column temperature 25°C; The flow rate of the mobile phase is 5mL / min; the detection wavelength of the detector is 214nm; the mixture of CBDV and the mobile phase is obtained in 140-200min based on the completion of sample injection at 0min; the cannabigerol is obtained in 210-280min The mixture of (CBG) and mobile pha...

Embodiment 2

[0027] Mix n-heptane, methyl tert-butyl ether, ethanol, and water in a volume ratio of 5:3:5:4 to prepare a solvent system, add it to a separatory funnel, shake it well, and let it stand for phase separation to obtain two phases For the mixed solution, the upper phase and the lower phase were collected separately, and placed in an ultrasonic oscillator for ultrasonic degassing. Dissolve the refined oil of the full spectrum of industrial hemp in the upper phase, the upper phase is the stationary phase, and the lower phase is the mobile phase; high-speed countercurrent chromatography is used for separation, and the chromatographic conditions are set as: forward rotation, speed 800rpm; column temperature 25°C; The flow rate of the mobile phase is 5mL / min; the detection wavelength of the detector is 214nm, and the sample injection is 0min, and the mixture of cannabidiol (CBDV) and the mobile phase is obtained in 100-140min; the cannabigerol is obtained in 150-200min The mixture of...

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Abstract

The invention relates to a method for simultaneously separating secondary cannabidiol and cannabigerol. The method comprises the following steps: sufficiently oscillating a solvent system, allowing the solvent system to stand, and separately collecting an upper phase and a lower phaser; dissolving an industrial hemp full-spectrum essential oil sold in the market into the upper phase, performing separation by using high-speed countercurrent chromatography by taking the upper phase as an immobile phase and the lower phase as a mobile phase so as to respectively obtain a mixed liquid of secondarycannabidiol and the mobile phase and a mixed liquid of cannabigerol and the mobile phase, and removing the mobile phase, so as to obtain the secondary cannabidiol and the cannabigerol. By adopting the method, a high-speed countercurrent chromatography technique is adopted for a first time to simultaneously separate and purify secondary cannabidiol (CBDV) of which the purity is greater than 98% and cannabigerol of which the purity is greater than 97% from the industrial hemp full-spectrum essential oil.

Description

technical field [0001] The invention belongs to the field of cannabinol processing, in particular to a method for simultaneously separating cannabidiol and cannabigerol. Background technique [0002] The molecular formula of Cannabidivarin is C 19 h 26 o 2 . Cannabidiol is found in industrial hemp. The extract containing cannabidiol can be obtained by extracting industrial hemp with alcohol. Cannabidiol (CBDV) can be used in the treatment of neurological disorders. [0003] The molecular formula of cannabigerol is C 21 h 32 o 2 . Cannabigerol is present in industrial hemp. The extract containing cannabigerol can be obtained by extracting industrial hemp with alcohol. Cannabigerol (CBG) can be used in the treatment of neurological disorders. [0004] The difference between the simultaneous separation of cannabidiol and cannabidiol by high-speed countercurrent chromatography and the separation of cannabidiol is that a different solvent system is used to achieve a b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C37/68C07C37/82C07C39/23C07C39/19
CPCC07C37/004C07C37/685C07C37/74C07C39/23C07C39/19C07C2601/16C07C37/72B01D15/1892
Inventor 邓力余琦
Owner SHANGHAI TAUTO BIOTECH CO LTD
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