Excellent clostridiumbutyricum for preventing ulcerative colitis

A technology for ulcerative colitis and clostridium butyricum, applied in the field of microbiology, can solve the problems of ulcerative colitis patents that have not been published, and achieve the effects of relieving colon structural damage, reducing weight loss, and good preventive effect

Inactive Publication Date: 2019-12-20
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the past 10 years, there have been more than 100 patents of various types with Clostridium butyricum as a component, and no patents that clarify the role of Clostridium butyricum in the prevention of ulcerative colitis have yet been published

Method used

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  • Excellent clostridiumbutyricum for preventing ulcerative colitis
  • Excellent clostridiumbutyricum for preventing ulcerative colitis
  • Excellent clostridiumbutyricum for preventing ulcerative colitis

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Embodiment Construction

[0029] The technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0030] An excellent Clostridium butyricum used to prevent ulcerative colitis, the strain was isolated from the intestinal contents of Songliao black piglets, identified as Clostridium butyricum by 16S rRNA gene sequence, and named Clostridium butyricum ( Clostridium butyricum) RAM0216, which was deposited in the General Microbiology Center of the China Committee for the Collection of Microbial Cultures on May 27, 2019. The preservation address is: Institute of Microbiology, Chinese Academy of Sciences...

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Abstract

The invention provides a strain of clostridiumbutyricum for preventing ulcerative colitis. The strain is preserved in CGMCC (China General Microbiological Culture Collection Center) on May 27, 2019, and the preservation number is CGMCC NO.17854. A C57BL / 6N mouse is used as an experiment object; DSS (Dextran Sulfate Sodium) is used for inducing the mouse to form an ulcerative colitis model; and themodel is used for investigating the effectiveness of the strain of the invention for preventing the ulcerative colitis. The clostridiumbutyricum provided by the invention can be used for effectivelyrelieving the body weight loss, diarrhea and hematochezia of the mouse with the ulcerative colitis induced by the DSS and effectively improving the DAI (Disease Activity Index) grade; the mouse colontissue pathologic lesion of the mouse induced by DSS can be protected; the epithelial barrier completeness of the colon tissues can be enhanced; and non-toxicity and harmlessness are realized.

Description

technical field [0001] The invention relates to the field of microbiology, in particular to an excellent Clostridium butyricum strain for preventing ulcerative colitis. Background technique [0002] Inflammatory bowel disease (IBD) is a chronic nonspecific inflammatory disease that occurs in the colon and small intestine, including ulcerative colitis (UC) and Crohn's disease (CD). IBD occurs in genetically susceptible individuals and is caused by an overactive T cell-mediated immune response to specific components of the gut microbiota, susceptible to recurrent episodes of environmental influences. The specific pathogenesis of IBD is still unclear, but it is generally believed to be caused by the combined effects of host genes, environmental factors, intestinal microorganisms and immune response. However, more and more studies have confirmed that gut microbes (bacteria, fungi and viruses) play a key role in the development of IBD. Early in the onset of IBD, the diversity o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20A61K35/742A61P29/00A61P1/00C12R1/145
CPCC12N1/20A61K35/742A61P29/00A61P1/00C12R2001/145C12N1/205
Inventor 谢秋宏宁可相宏宇王彦博张莹
Owner JILIN UNIV
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