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Dropping pill for clearing heat from throat and production method of dropping pill for clearing heat from throat

A technology of pharynx drop pills and drop pills, which is applied in the field of Qingyan drop pills and its preparation, can solve the problems of unsuitable Qingyan drop pills, poor taste of menthol and borneol, loss of menthol and borneol, etc., to reduce losses, The effect of large drug loading and simple preparation method

Inactive Publication Date: 2019-12-27
GUANGZHOU LIXIN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the inclusion of cyclodextrin helps to improve the stability of menthol and borneol in the preparation and storage process, there are also the following problems: due to the problem of encapsulation efficiency, menthol and borneol have a certain loss during the inclusion process ; And the mouthfeel of menthol and borneol after inclusion is poor, therefore, is not suitable for the Qingyan dropping pill of oral administration

Method used

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  • Dropping pill for clearing heat from throat and production method of dropping pill for clearing heat from throat
  • Dropping pill for clearing heat from throat and production method of dropping pill for clearing heat from throat
  • Dropping pill for clearing heat from throat and production method of dropping pill for clearing heat from throat

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Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1: the preparation of Qingyan Dropping Pill No. 1

[0041] The present embodiment has prepared a kind of Qingyan dripping pill No. 1, and its formula is as follows:

[0042]

[0043] Get each component of above-mentioned formula quantity, prepare as follows:

[0044] The raw material refining of step (1):

[0045] Take the indigo naturalis of formula quantity, add 6 times the weight of the hydrochloric acid aqueous solution with the volume concentration of 21%, soak for 6 hours, wash with water until neutral, dry, and obtain the refined product of indigo naturalis;

[0046] Take the licorice root of the formula, add water and reflux to extract 3 times, add 10 times the weight of water for the first time, add 8 times the weight of water for the second and third times, reflux each time for 3 hours, combine the filtrates, and concentrate to 70 ° C. The clear paste with a density of 1.2, then add ethanol until the volume concentration of ethanol is 85%, let ...

Embodiment 2

[0052] Embodiment 2: the preparation of Qingyan Dropping Pill No. 2

[0053] The present embodiment has prepared a kind of Qingyan dripping pill No. 2, and its formula is as follows:

[0054]

[0055]

[0056] Get each component of above-mentioned formula quantity, prepare as follows:

[0057] The raw material refining of step (1):

[0058] Take the indigo naturalis of formula quantity, add 6 times the weight of the hydrochloric acid aqueous solution with the volume concentration of 27%, soak for 4 hours, wash with water until neutral, dry, and obtain the refined product of indigo naturalis;

[0059] Take the licorice root of the formula, add water and reflux to extract twice, add 12 times the weight of water for the first time, add 10 times the weight of water for the second time, reflux each time for 3 hours, combine the filtrates, concentrate to 70 DEG C when the relative density is 1.2 clear paste, then add ethanol until the volume concentration of ethanol is 75%, ...

Embodiment 3

[0065] Embodiment 3: the preparation of Qingyan Dropping Pill No. 3

[0066] The present embodiment has prepared a kind of Qingyan dripping pill No. 3, and its formula is as follows:

[0067]

[0068] Get each component of above-mentioned formula quantity, prepare as follows:

[0069] The raw material refining of step (1):

[0070] Take the indigo naturalis of formula quantity, add 6 times the weight of the hydrochloric acid aqueous solution with the volume concentration of 15%, soak for 12 hours, wash with water until neutral, dry, and obtain the refined product of indigo naturalis;

[0071] Take the licorice root of the formula, add water and reflux to extract 3 times, add 10 times the weight of water for the first time, add 8 times the weight of water for the second and third times, reflux each time for 3 hours, combine the filtrates, and concentrate to 70 ° C. Clear paste with a density of 1.2, then add ethanol until the volume concentration of ethanol is 70%, let it ...

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Abstract

The invention discloses a dropping pill for clearing heat from a throat and a production method of the dropping pill for clearing heat from the throat. According to the dropping pill for clearing heatfrom the throat and the production method of the dropping pill for clearing heat from the throat, artificial calculus bovis, a highly-finished product of indigo naturalis, a licorice extract, a fructus chebulae extract and a matrix polyethylene glycol 6000 are made into a dropping pill inner core, menthol and borneol are used as a coating layer for coating the dropping pill inner core, and then an external isolating coating layer is used for coating the coating layer. According to the dropping pill for clearing heat from the throat and the production method of the dropping pill for clearing heat from the throat, the use amount of the matrix is reduced, the drug-loading capacity is improved, and high-temperature exposure of the menthol and the borneol is reduced, so that volatilization loss of the menthol and the borneol is reduced.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a Qingyan dripping pill and a preparation method thereof. Background technique [0002] Qingyan Dropping Pills is recorded in the 14th volume of "Standards for Standardization of New Drugs". It is a product launched by the Sixth Traditional Chinese Medicine Factory of Tianjin Zhongxin Pharmaceutical Group Co., Ltd. It is prepared from artificial bezoar, myrobalan, indigo naturalis, licorice, menthol and borneol as raw materials, and polyethylene glycol 6000 as an auxiliary material. Its functions and indications are dispelling wind and clearing heat, detoxifying and relieving sore throat; it is used for wind-heat sore throat, sore throat, dry throat, thirst, or slight evil wind, fever, red and swollen throat, and acute pharyngitis with the above syndromes. [0003] For the preparation method of Qingyan Dropping Pills, Ministry Standard No. WS3...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61K36/484A61K9/36A61K47/10A61P11/04A61K31/045A61K35/413
CPCA61K9/2031A61K9/209A61K9/2866A61K31/045A61K35/413A61K36/185A61K36/195A61K36/315A61K36/484A61K36/704A61P11/04A61K2300/00
Inventor 高悦译
Owner GUANGZHOU LIXIN PHARM CO LTD