Blank wax stone drilling machine for tissue chip

Abstract

The invention provides a blank wax stone drilling machine for a tissue chip. The drilling machine includes a base, a bracket, a horizontal movement mechanism, a vertical movement mechanism, a drillingmechanism and a wax stone fixing seat. The bracket is connected with the base; the horizontal movement mechanism comprises two horizontal movement components which are mutually vertically connected,namely, the X-axis movement component and the Y-axis movement component; scales and / or grating rulers are arranged on the horizontal movement components, one horizontal movement component is connectedwith the base, and the other horizontal movement component is connected with the wax block fixing seat; the vertical movement mechanism includes a Z-axis movement component and a Z-axis limiting component, the Z-axis movement component is connected with the bracket and the drilling mechanism respectively, and the Z-axis limiting component is arranged on the Z-axis movement component for limitingthe maximum displacement of the Z-axis movement component. The drilling mechanism includes a drill bit, a first transmission device and a first motor, wherein the first motor is connected with the drill bit through the first transmission device.

Description

technical field [0001] The invention relates to the field of biochemistry, in particular to a tissue chip blank paraffin block drilling instrument. Background technique [0002] Tissue chip (tissue chip), also known as tissue microarray (tissue microarray, TMA), is a tissue section made by neatly arranging dozens to thousands of small tissues on a glass slide. Another important biochip that appeared after the chip is mainly used to study the expression of the same gene or protein molecule in different cells or tissues. Use a tissue microarray spotter to arrange the marked tissues on the blank paraffin block according to the design. First of all, it is necessary to use a drill to punch holes on the marked target sites, and then transfer the tissue cores into the holes of the wax block. Repeated operations can transfer thousands of sample tissue cores, and then use a microtome to process the array wax blocks. Tissue microarrays are obtained by serial sectioning. [0003] In...

AI Technical Summary

Problems solved by technology

[0003] During the production of tissue microarray, the area of ​​the wax block is small, the arrangement of tissue sample points is messy, and the limited area of ​​the wax block is seriously wasted.

The existing preparation process mostly uses hollow needles to extract the wax core of the blank wax block. The biggest drawback is that the needle wall has a certain thickness, and occupies a limited area on the wax block in the space of 1 / 100 or 1 / 1000mm. The space is not small, resulting in a great degree of waste; after the hollow needle takes out the wax core, the wax core must be pushed out to perform the same operation again, which is cumbersome and time-consuming

The horizontal and vertical movement of the existing fixer is fixed by two suspended springs, and its accuracy is obviously reduced. Obviously unbalanced; in the process of wax block production, it is often encountered that it is necessary to pause or retreat during the forward movement process. Manpower and material resources

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