HPV infection-resisting pharmaceutical composition and application thereof

A composition and drug technology, applied in the field of medicine and health, can solve the problems of limited drugs, achieve the effects of maintaining biological activity, scientific and reasonable material selection and compatibility, and improving the crushing rate

Active Publication Date: 2020-01-03
北京皓尔生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current drugs for the treatment of cervical cancer are limited, and finding reasonable and effective drugs is still the focus of research.

Method used

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  • HPV infection-resisting pharmaceutical composition and application thereof
  • HPV infection-resisting pharmaceutical composition and application thereof
  • HPV infection-resisting pharmaceutical composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～ Embodiment 4

[0017] Embodiment 1~Example 4 Preparation of a pharmaceutical composition powder for resisting HPV infection

[0018] Table 1 is the specific formula of a kind of anti-HPV infection pharmaceutical composition of embodiment 1-embodiment 4.

[0019] Table 1 4 concrete formulas of embodiment 1~embodiment 4 of the present invention

[0020]

[0021] A1~A4 preparation method in embodiment 1~embodiment 4:

[0022] (1) Dry the cleaned comfrey, Phellodendron sichuanensis, Astragalus membranaceus, green tea, honeysuckle, dandelion, flavescens, sealwort, angelica, Brucea javanica, Smilax cocos, Houttuynia cordata, and Bean root at 45-50°C to constant weight;

[0023] (2) Weigh the dried Chinese medicinal materials according to the parts by weight in each formula, mix them and place them in an ultrafine pulverizer to pulverize them to obtain ultrafine powdered Chinese medicinal materials, whose particle size is 0.1-75 μm, and whose uniformity The coefficient of variation is less th...

Embodiment 5

[0024] Example 5 Preparation of an anti-HPV infection pharmaceutical composition ointment

[0025] Pharmaceutical composition composition: No. A1~A4 formula in embodiment 1~embodiment 4

[0026] Preparation method: Weigh the pharmaceutical compositions A1-A4 in Examples 1-4, add 20%-30% sesame oil, stir evenly and make ointment to obtain anti-HPV infection ointment B1-B4.

Embodiment 6～ Embodiment 8

[0027] Example 6-Example 8 Preparation of another anti-HPV infection pharmaceutical composition

[0028] Table 2 The specific formula of another kind of anti-HPV infection pharmaceutical composition

[0029]

[0030] The preparation method of C1~C3 in embodiment 6~embodiment 8:

[0031] (1) After cleaning and removing impurities from each traditional Chinese medicine, dry it at 40°C for subsequent use;

[0032] (2) Add ethanol to comfrey, green tea, dandelion, honeysuckle, houttuynia cordata, and Eucommia respectively, carry out low-temperature extraction three times at 35-45°C, filter, combine the filtrates, concentrate to an appropriate amount, and obtain the alcohol content of each Chinese herbal medicine respectively. Extract;

[0033] (3) Add Phellodendron sichuanensis, Astragalus membranaceus, Sophora flavescens, Polygonatum, Angelica, Brucea javanica, Smilax cocos, and Bean root to low-temperature extraction three times at 40-50°C, filter, combine the filtrates, an...

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Abstract

The present invention relates to an HPV infection-resisting pharmaceutical composition and an application thereof, and belongs to the technical field of medicine and health. The composition is mainlyprepared from a radix arnebiae pulverized material, a cortex phellodendri amurensis pulverized material, a radix astragali pulverized material, etc., and can be prepared into powder, tablets, capsulesor ointment. The other composition is prepared from a radix arnebiae alcohol extract, a cortex phellodendri amurensis water extract, a radix astragali water extract, then propylene glycol, deionizedwater, antimicrobial peptides, etc., and can be prepared into suppositories, gels, lotions, foaming agents or ointment. Through synergistic effects of the various raw materials, the HPV infection-resisting pharmaceutical composition has effects of clearing heat, eliminating dampness, removing toxins and blood stasis and enhancing body immune functions, effectively inhibiting and eliminating HPV viruses and also preventing inflammation, can obviously prevent re-infection of the HPV viruses, can be used for preventing and treating clinical symptoms caused by HPV infection, particularly common warts, flat warts, vulvar cancer, anal cancer, cervical cancer, etc.

Description

technical field [0001] The invention belongs to the technical field of medicine and health, and in particular relates to a pharmaceutical composition for resisting HPV infection and its application. Background technique [0002] Cervical cancer has now become one of the most important malignant tumors threatening women's health around the world. The incidence and mortality of new diseases are increasing every year around the world, and the age of onset is gradually becoming younger. The annual number of new cases in the world is as high as 500,000, of which the rate in developing countries is more than 50%. Every year, about 200,000 women in the world die from this disease, which has seriously threatened women's physical and mental health. In my country, there are 140,000 new cases of cervical cancer each year. Early detection and treatment of cervical cancer and precancerous lesions is the main method to reduce the mortality rate. [0003] Human Papilloma Virus (HPV) is a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61K36/78A61K36/8969A61K36/90A61K36/896A61K36/82A61K38/02A61P31/20A61P35/00
CPCA61K38/02A61K36/30A61K36/756A61K36/481A61K36/288A61K36/82A61K36/355A61K36/489A61K36/8969A61K36/232A61K36/185A61K36/90A61K36/896A61K36/78A61K36/46A61K36/284A61K36/59A61P31/20A61P35/00A61K2300/00
Inventor 刘春辉李自托
Owner 北京皓尔生物科技有限公司
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