Gestational diabetes mellitus micro RNA marker combination and application thereof

A technology of gestational diabetes and markers, applied in the field of biomedicine, can solve the problems of prone to false positives, slow gene mutation, and decreased detection accuracy of markers, and achieve the effect of improving detection sensitivity
CN110643701AActive Publication Date: 2020-01-03SOUTHWEST MEDICAL UNIVERISTY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SOUTHWEST MEDICAL UNIVERISTY
Publication Date
2020-01-03

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Abstract

The invention belongs to the technical field of biomedicine, and particularly discloses a micro RNA marker combination related to gestational diabetes and application thereof. The micro RNA marker combination comprises miR-132 and miR-375. The invention further discloses a preparation method of the micro RNA marker combination. The miR-132 and the miR-375 are located in peripheral blood serum or blood plasma. The miR-132 and the miR-375 can be used as diagnostic markers for the gestational diabetes, and a basis is provided for early diagnosis of the gestational diabetes mellitus.
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Description

Technical field

[0001] The invention belongs to the field of biomedical technology, and specifically relates to providing a combination of microRNA markers for gestational diabetes and its application. Background technique

[0002] Gestational diabetes is a complication of pregnancy. The current clinical diagnosis is mainly based on the detection of pregnant women's blood glucose in the second trimester. Since gestational diabetes may cause fetal malformations, and severe cases endanger the health of mothers and infants, the earlier the diagnosis of gestational diabetes is, the better it is for the patient. .

[0003] MicroRNA (microRNA) is a type of small non-coding RNA with a molecular weight of 18-25 bases. MicroRNA is highly conserved in evolution and participates in the regulation of gene expression after transcription. It regulates gene expression and its expression at the post-transcriptional and translational levels. The abnormality is closely related to gestational diabet...

Claims

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