Bone defect repair stent, construction method, preparation method, computer readable storage medium and equipment

A construction method and bone defect technology, applied in metal processing equipment, additive manufacturing, manufacturing tools, etc., can solve problems such as lack of geometric shape and mechanical properties, low osteoconduction and osteoinductive ability, and inability of materials to be accurately reconstructed and repaired , to achieve the effect of improving mechanical strength, expanding the scope of clinical application, and realizing personalized design

Pending Publication Date: 2020-01-14
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, for complex hard tissue morphology and functional abnormalities, the current bone repair technology and materials cannot be accurately reconstructed and repaired, and there is an urgent need to develop personalized bone repair implant devices
Traditional implanted prosthesis materials such as stainless steel and titanium alloys do not have specific biological functions, have low osteoconduction and osteoinduction capabilities, and do not have the geometric shape and mechanical properties that match the lesion site, so they cannot be effectively realized. regeneration and repair of bone tissue

Method used

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  • Bone defect repair stent, construction method, preparation method, computer readable storage medium and equipment
  • Bone defect repair stent, construction method, preparation method, computer readable storage medium and equipment
  • Bone defect repair stent, construction method, preparation method, computer readable storage medium and equipment

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preparation example Construction

[0065] The third aspect of the present invention provides a preparation method of the bone defect repair scaffold described above, the preparation method comprising: constructing a bone defect repair scaffold model according to the construction method of the above bone defect repair scaffold model, and preparing a bone defect repair scaffold.

[0066] In a preferred embodiment, the scaffold for bone defect repair is prepared by 3D printing.

[0067] According to the reverse modeling of the patient's imaging (CT data and / or MRI data), a computer STL file is generated, and then the file is transferred to the program of the 3D printer to start printing. The material of the bone defect repair scaffold includes two kinds: a mixture of biodegradable polymer and biodegradable inorganic substance, and cell hydrogel. The mixture of the biodegradable polymer and the biodegradable inorganic substance can be melt-blended, and a single-screw or twin-screw mixer can be used. The preparatio...

Embodiment 1

[0073] A bone defect repair bracket, comprising a bone defect repair bracket body 1, the bone defect repair bracket body 1 includes several bracket layers 11, the bracket layer 11 includes several parallel bracket ribs, and the bracket ribs include first The bracket ribs 111 and the second bracket ribs 112, the bracket ribs of adjacent layers intersect to form micropores, the cross angle α of the bracket ribs of adjacent layers is 60°, and the shape of the bone defect repair bracket is bone tissue defect The material of the first bracket rib 111 is a mixture of biodegradable polymers and biodegradable inorganic substances, the material of the second bracket rib 112 is cell hydrogel, and every other bracket layer The first bracket ribs 111 and the second bracket ribs 112 in the two support layers are arranged in parallel, and the first bracket ribs 111 and the second bracket ribs 112 on the same layer are alternately arranged, and the bracket layer 11 includes Several support u...

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Abstract

The invention provides a bone defect repair stent, a construction method, a preparation method, a computer readable storage medium and equipment. The bone defect repair stent comprises a bone defect repair stent body, several stent layers, the stent layer comprises a plurality of parallel stent beads; the stent beads comprise a first stent bead and a second stent bead, and adjacent layers of stentbeads are crossed to form micropores, the shape of the bone defect repair stent is the shape of a defective bone tissue, the material of the first stent bead comprises a biodegradable polymer and a biodegradable inorganic substance, and the material of the second stent bead is cell hydrogel. According to the bone defect repair stent, a biodegradable polymer containing biodegradable inorganic matters such as bone induction active magnesium particles is used as a base material, in combination with the cell hydrogel, modeling preparation such as 3D biological printing preparation is carried out,the advantages of polymer, metal and biological printing are effectively combined, and good biocompatibility, biodegradability, osteoconductivity and osteoinductivity are achieved.

Description

technical field [0001] The invention belongs to the technical field of bone repair, and in particular relates to a bone defect repair bracket, its construction and preparation method, a computer-readable storage medium and equipment. Background technique [0002] Bone defect refers to the destruction of the structural integrity of bone, and its common causes include trauma, infection, bone tumor, and osteonecrosis. At present, the clinical treatment of large bone defects caused by open fractures and bone tumors is mainly based on filling and repairing. When the defect site may or has been accompanied by infection, anti-infection treatment should be carried out while the bone defect is being repaired. In addition, for complex hard tissue abnormalities in shape and function, current bone repair technologies and materials cannot be accurately reconstructed and repaired, and there is an urgent need to develop personalized bone repair implant devices. Traditional implanted prost...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28
CPCA61F2/28A61F2002/2817A61F2002/2835A61F2002/30062A61F2002/30772A61F2002/3093A61F2002/30985
Inventor 赵双郝永强姜闻博谢凯郭煜王磊
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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