Unlock instant, AI-driven research and patent intelligence for your innovation.

Compound metformin hydrochloride osmotic pump controlled-release capsule and preparation method thereof

A technology for compounding metformin hydrochloride and metformin hydrochloride, which is applied in the directions of capsule delivery, pharmaceutical formulations, medical preparations of inactive ingredients, etc.

Inactive Publication Date: 2020-01-21
ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This technology mainly solves the problem of the controlled release of the insoluble drug gliclazide and the water-soluble drug metformin hydrochloride. The present invention uses osmotic pump technology to design the two drugs into a three-layer osmotic pump controlled release capsule. The capsule core is composed of The booster layer in the middle is composed of two upper and lower drug layers, and each of the upper and lower drug layers has a drug release hole

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound metformin hydrochloride osmotic pump controlled-release capsule and preparation method thereof
  • Compound metformin hydrochloride osmotic pump controlled-release capsule and preparation method thereof
  • Compound metformin hydrochloride osmotic pump controlled-release capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Preparation of compound gliclazide acid metformin three-layer osmotic pump controlled-release capsules

[0019] 1. Capsule core prescription:

[0020] Gliclazide Layer Prescription:

[0021]

[0022] Booster layer prescription:

[0023] Sodium chloride 35mg

[0024] Polyoxyethylene (wsr-303) 60mg

[0025] Hypromellose 2mg

[0026] Metformin hydrochloride layer prescription:

[0027]

[0028] Capsule liquid prescription:

[0029]

[0030] 2. Preparation process:

[0031] Preparation of infiltrated capsule shells:

[0032] (1) To prepare capsule liquid, since polyethylene glycols are water-soluble materials, a certain amount of water is first added to dissolve it when preparing; stand to remove air bubbles.

[0033] (2) Use the glue dipping process to dip in the glue. After dipping in the glue for a certain number of times, pull out the shell, cut and arrange it, and then the capsule shell of the osmotic pump can be positioned.

[0034]Preparation of Com...

Embodiment 2-9

[0071] The composition and dosage of prescription 2-9 are shown in the table below, except for the components listed in the table, the rest are the same as prescription 1.

[0072] Table 1-9 composition and dosage of prescription

[0073]

[0074] Preparation process: with embodiment 1

[0075] Preparation of permeable capsule shell: same as Example 1

[0076] Preparation of Compound Gliclazide Hydrochloride Metformin Osmotic Pump Capsules: Same as Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a compound metformin hydrochloride osmotic pump controlled-release capsule and a preparation method thereof, and mainly solves the problem of controlled release of both a poorly soluble drug gliclazide and a water-soluble drug metformin hydrochloride. The osmotic pump controlled-release capsule is a compound gliclazide metformin hydrochloride three-layer osmotic pump controlled-release capsule, a capsule core is composed of a middle boosting layer and upper and lower two drug-containing layers, the capsule core is placed in an osmotic pump controlled-release capsule shell, and the top end and the bottom end of the osmotic pump controlled-release capsule shell are respectively provided with one drug-release small hole. When water enters the boosting layer, the boosting layer swells to prompt the two drugs to be released from two drug rooms respectively. The system can realize the simultaneous zero-order release of gliclazide and metformin hydrochloride, a stableblood concentration is obtained, the number of taking medicine is reduced, side effects are reduced, patient compliance is improved, and relatively good treatment effects are obtained.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a compound metformin hydrochloride osmotic pump controlled-release capsule and a preparation method thereof. Background technique [0002] Diabetes has the characteristics of systemic metabolic diseases and is a chronic endocrine disease. At present, all kinds of disabling or fatal acute and chronic complications caused by diabetes have become the third largest threat to human life and health after cardiovascular diseases and malignant tumors. Suffering from diabetes will also seriously affect the quality of life of patients, and bring an increasingly heavy economic and medical burden to patients and the whole society. With the continuous improvement of people's living standards in our country, the incidence of diabetes will continue to increase. Diabetes is a progressive disease. Under the condition that the current medical level cannot cure it, diabetic pati...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K47/10A61K47/38A61K47/32A61K31/64A61K31/155A61P3/10
CPCA61K9/4808A61K9/4816A61K9/4866A61K31/64A61K31/155A61P3/10
Inventor 胡容峰陆文捷高松陈艳君
Owner ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE