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Application of Extzw in preparation of anti-ulcerative colitis drugs for digestive tract

An ulcerative colitis and extract technology, which is applied in the application field of Wenwang Yibi Extract, can solve problems such as untreated ulcerative colitis, and achieve good anti-inflammatory effect and safety effect.

Pending Publication Date: 2020-01-21
CHINA THREE GORGES UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In summary, there is currently no ideal drug for the treatment of ulcerative colitis; in addition, the incidence of ulcerative colitis in my country has been on the rise in recent years, therefore, further research and development of corresponding new drugs for ulcerative colitis Therapeutic drugs have important theoretical and practical significance

Method used

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  • Application of Extzw in preparation of anti-ulcerative colitis drugs for digestive tract
  • Application of Extzw in preparation of anti-ulcerative colitis drugs for digestive tract
  • Application of Extzw in preparation of anti-ulcerative colitis drugs for digestive tract

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Embodiment 1

[0039] 1. Drug source, drug extraction and preparation

[0040] The Wen Wang Yizhi pen mentioned in the present invention was collected in Damiao Township, Shiyan City, Hubei Province, and was identified as the whole herb of Balanophora involucrata, which is a kind of medicinal plant in the above-mentioned genus Balanophora. We have also collected a variety of medicinal plants of the genus Serpentis in Enshi, Yichang and other western Hubei regions, as well as in parts of Yunnan, Sichuan, Guangdong, Jiangxi, Hunan, Hubei and Guizhou.

[0041] The original plant of Wenwang Yibi is excavated to remove soil and impurities, sliced ​​and dried in the shade. After the whole herb is chopped or crushed, use water as a solvent, heat and reflux extraction, the number of extractions is 3 times, each time 2 hours, the amount of solvent used for each extraction is 15 times the weight of the medicinal material, and filtered. The filtrate was collected, concentrated and filtered again to vo...

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Abstract

The invention relates to application of Extzw in preparation of anti-ulcerative colitis drugs for a digestive tract. The extract is a supernatant and precipitate obtained by water extraction and alcohol precipitation of Balanophora involucrata. After the supernatant is decompressed to recovery ethanol, an extract of an ethyl acetate portion and an extract of an n-butanol portion are separately obtained by extracting ethyl acetate and n-butanol sequentially, and the precipitate is washed and dried by alcohol to obtain an extract of a water extraction and alcohol precipitation portion. The Extzwand the extracts of the ethyl acetate portion and the water extraction and alcohol precipitation portion prepared from the Extzw have obvious improvement on dextran sulfate sodium (DSS)-induced ulcerative colitis in mice, can be applied to the preparation of the anti-ulcerative colitis drugs for the digestive tract, and even to the preparation of other drugs for the treatment of intestinal inflammatory diseases.

Description

technical field [0001] The invention relates to the technical field of application of Wenwangyibi extract, in particular to the application of Wenwangyibi extract in preparing digestive tract anti-ulcerative colitis medicine. Background technique [0002] Inflammation is a biological response involving many types of immune and nonimmune cells that protects the body from damage caused by harmful stimuli. Typically, the inflammatory response is triggered by exogenous substances and products of tissue damage, accompanied by the production of pro-inflammatory cytokines, the recruitment and activation of immune cells, and the generation of free radicals. Normally, these inflammatory processes remove foreign bodies and pathogens and promote tissue regeneration, however, during certain disease processes, the inflammatory response becomes excessive, causing acute or chronic inflammatory responses and associated tissue / organ damage . Therefore, controlling the excessive inflammator...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P1/00A61P1/04
CPCA61K36/185A61P1/00A61P1/04A61K2236/331A61K2236/333A61K2236/53Y02A50/30
Inventor 袁成福何毓敏屈家源郭冲柳宇
Owner CHINA THREE GORGES UNIV
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