A kind of eye drop, preparation method and its application in the medicine of corneal injury treatment
A technology for eye drops and drugs, which is applied in drug combinations, drug delivery, and pharmaceutical formulations. It can solve the problems of decreased expression after increased expression, no reports, and no application of FGF9 eye medications, etc., and achieves simple preparation process and high efficacy. Definite, good curative effect
Active Publication Date: 2021-02-02
XIAMEN UNIV
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Problems solved by technology
Our previous experiments found that the distribution of FGF9 and FGFR3 in the limbus was significantly higher than that in the central cornea, and during the healing process of corneal epithelial injury, the expression of FGF9 showed a trend of first increasing and then decreasing, which suggests that FGF9 plays an important role in corneal epithelial injury. It plays an important role in the healing process, but at present, there is no report on the specific role of FGF9 in the corneal epithelium and corneal endothelium, and there is no report on the application of FGF9 to prepare ocular medicine
Method used
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Experimental program
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Effect test
Embodiment 1
[0039] 1000 ng of rhFGF9 was dissolved in 100 ml of normal saline to prepare eye drops with a rhFGF9 concentration of 10 ng / ml, sterilized and filtered, and distributed in eye drops bottles. Adjust the pH to 7.2 with sodium dihydrogen phosphate and hydrochloric acid. The rhFGF9 is peprotech100-23-100rhFGF9 (the following rhFGF9 is the same type).
Embodiment 2
[0041] 2000 ng of rhFGF9 was dissolved in 100 ml of PBS buffer solution with a pH of 7.2 to prepare eye drops with a rhFGF9 concentration of 20 ng / ml, sterilized and filtered, and distributed in eye drops bottles.
Embodiment 3
[0043] 8000 ng of rhFGF9 was dissolved in 100 ml of PBS buffer solution with pH 7.2 to prepare eye drops with a rhFGF9 concentration of 80 ng / ml, sterilized and filtered, and distributed in eye drops bottles.
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Abstract
The invention provides an eye drop for treating corneal epithelial damage, which comprises fiber growth factor 9 and a solvent. The eye drop has remarkable curative effect on corneal epithelial injury and has no toxic and side effects.
Description
technical field [0001] The invention relates to a method for preparing eye drops and its application in corneal damage treatment drugs, belonging to the technical field of eye drops. Background technique [0002] Corneal epithelial injury refers to the pathological state in which the function and integrity of the corneal epithelial barrier are destroyed due to various factors, resulting in partial or complete loss of the corneal epithelial cell layer. Clinically, it can be manifested as diffuse punctate loss or erosion of the corneal epithelium, repeated exfoliation and defect of the corneal epithelium, accompanied by varying degrees of ocular surface inflammatory reactions, and severe cases can lead to corneal stromal lesions and affect visual function. [0003] There are many pathogenic factors that cause corneal epithelial damage, which can be divided into two categories: congenital and acquired. Congenital pathogenic factors mainly refer to various types of corneal epit...
Claims
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IPC IPC(8): A61K9/08A61K47/02A61K38/18A61P27/02
CPCA61K9/0048A61K9/08A61K38/1825A61K47/02A61P27/02
Inventor 李炜欧尚坤于静雯吴涵何卉刘祖国
Owner XIAMEN UNIV