Bone regeneration guiding collagen membrane for dental use and preparation method thereof

A technology for guiding regeneration and collagen membrane, applied in the fields of medical science, pharmaceutical formulation, surgery, etc., it can solve the problems of inability to effectively prevent soft tissue from growing into the tooth socket, unfavorable exchange of materials in trauma, occupying space for bone tissue growth, etc. Membrane degradation time, beneficial to repair and healing, and the effect of controllable degradation
CN110743044AActive Publication Date: 2020-02-04BEIJING YH BIOMAX BIOLOGIC TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING YH BIOMAX BIOLOGIC TECH
Publication Date
2020-02-04

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Abstract

The invention discloses bone regeneration guiding collagen membrane for dental use and a preparation method thereof, and belongs to the technical field of regenerative medical materials. The preparation method of the bone regeneration guiding collagen membrane for dental use comprises the following steps: S1, preparing a raw material and carrying out pretreatment, including: S1-1, dissolving type-I collagen in an acidic solvent and carrying out homogenization so as to obtain collagen slurry, S1-2, filtering the collagen slurry, and S1-3, performing negative-pressure pumping on the collagen slurry filtered in S1-2 until no obvious bubbles exist; S2, carrying out freeze-drying, namely freeze-drying the collagen slurry prepared in S1 so as to obtain collagen sponge; S3, pressing the collagensponge into a thin piece, namely pressing the collagen sponge into a thin piece under a pressure of 1-5 MPa; and S4, performing severe dehydration and cross-linking on the thin piece in vacuum so as to obtain the bone regeneration guiding collagen membrane for dental use, and carrying out sterilizing and storing. The bone regeneration guiding collagen membrane for dental use disclosed by the invention can be used to stop bleeding and guide bone regeneration after dental implantation, and has the advantages of being low in immunogenicity, excellent in biocompatibility and capable of effectivelypromoting bone regeneration. Moreover, the preparation method of the bone regeneration guiding collagen membrane for dental use has the advantages of being efficient and easy in operation, non-toxicand harmless.
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Description

technical field

[0001] The invention relates to the technical field of regenerative medical materials, more specifically, it relates to a bone-guiding regenerative collagen film in the department of stomatology and a preparation method thereof. Background technique

[0002] In recent years, with the continuous development of implant technology, dental implant technology has played an increasingly important role in the restoration of missing teeth and achieved good results. However, in actual clinical practice, due to factors such as bone tissue defect and bone resorption, the alveolar ridge is too low or partially depressed in some patients, resulting in lateral perforation, which leads to failure of implant placement.

[0003] With the application of guided bone regeneration (Guided Bone Regeneration, GBR), the above problems have been solved to a certain extent. The specific clinical operation of dental implant technology is to form a tooth socket after tooth extraction, ...

Claims

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