Preparation method of silicon dioxide material with hierarchical pore structure

A technology of silica and hierarchical pores, which is applied in the direction of silica, silicon oxide, chemical instruments and methods, etc., can solve the problems of complex synthesis methods of hierarchical porous structures and inability to prepare large-scale The effect of preparation production, high yield and simple preparation procedure

Active Publication Date: 2020-02-07
LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The currently reported synthetic methods with hierarchical porous structures are complex and cannot be prepared on a large scale

Method used

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  • Preparation method of silicon dioxide material with hierarchical pore structure
  • Preparation method of silicon dioxide material with hierarchical pore structure
  • Preparation method of silicon dioxide material with hierarchical pore structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Weigh 100 mg of sodium salicylate and 1000 mg of cetyltrimethylammonium bromide, add 60 ml of deionized water, and stir at 60°C for 1 hour to form a homogeneous solution. Add 200 mg of triethanolamine to the above solution and continue to stir for 0.5 hours. Add 9 ml of tetraethyl orthosilicate and stir for 12 hours at a constant temperature in an oil bath at 60°C. After cooling to room temperature, centrifuge at 10,000 rpm for 10 minutes, collect the precipitate, wash the precipitate 3 times with ethanol; dry; the obtained solid is calcined at 600°C for 6 hours to obtain 2.113 g of a hierarchical pore structure with a particle size of 50 nm Dendritic silica material with a yield of 88.0%.

Embodiment 2

[0030] Weigh 500 mg of sodium salicylate and 1000 mg of cetyltrimethylammonium bromide, add 60 ml of deionized water, and stir at 60°C for 1 hour to form a homogeneous solution. Add 200 mg of triethanolamine to the above solution and continue to stir for 0.5 hours. Add 9 ml of tetraethyl orthosilicate and stir for 12 hours at a constant temperature in an oil bath at 60°C. After cooling to room temperature, centrifuge at 10,000 rpm for 10 minutes, collect the precipitate, wash the precipitate 3 times with ethanol; dry; the obtained solid is calcined at 600°C for 6 hours to obtain 2.169 g of a 300-nanometer particle with a hierarchical pore structure Dendritic silica material with a yield of 90.3%.

Embodiment 3

[0032] Weigh 1000 mg of sodium salicylate and 1000 mg of cetyltrimethylammonium bromide, add 60 ml of deionized water, and stir at 60°C for 1 hour to form a homogeneous solution. Add 200 mg of triethanolamine to the above solution and continue to stir for 0.5 hours. Add 9 ml of tetraethyl orthosilicate and stir for 12 hours at a constant temperature in an oil bath at 60°C. After cooling to room temperature, centrifuge at 10,000 rpm for 10 minutes, collect the precipitate, wash the precipitate 3 times with ethanol; dry; the obtained solid is calcined at 600°C for 6 hours to obtain 2.215 g of a hierarchical pore structure with a particle size of 500 nm Dendritic silica material with a yield of 92.3%.

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Abstract

The invention belongs to the field of nanometer materials, and relates to a preparation method of a silicon dioxide material with a hierarchical pore structure. Tetraethyl orthosilicate is adopted asa silicon source, triethanolamine is adopted as a basic catalyst, sodium salicylate and hexadecyl trimethyl ammonium bromide are adopted as a structure-directing agent and a template, and the silicondioxide material with the hierarchical pore structure is prepared in a water solution. The silicon dioxide material prepared through the method is uniform in particle size and larger in pore volume, and not only has a dendritic large pore path structure radially from inside to outside but also has a small-size mesoporous structure. The method provided by the invention is simple to prepare, low incost, good in repeatability and friendly to the environment, the particle size is adjustable in the range from 50 to 500nm, and large-scale preparation can be realized. The silicon dioxide material with the hierarchical pore structure prepared by the invention can be applied to a drug delivery carrier, and particularly has a remarkable advantage on a common load of small molecule drugs and high molecular weight protein.

Description

Technical field [0001] The invention relates to a functional material and a preparation method, in particular to a silicon dioxide material with a hierarchical pore structure, and a preparation method thereof. Background technique [0002] In recent years, dendritic mesoporous silica materials have received more and more attention as drug delivery vehicles in the fields of biology and medicine. As a novel mesoporous silicon material, dendritic mesoporous silica material not only has the advantages of traditional mesoporous silicon material such as large surface area, high stability, and good biocompatibility, but also because of its emission from the inside to the outside. The dendritic macroporous structure has a larger pore volume, higher pore permeability and better accessibility to the inner surface of the particles. This mesoporous material as a drug delivery carrier has significant advantages for loading drugs or proteins with different molecular weights. In particular, d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B33/18B82Y30/00B82Y40/00
CPCC01B33/186B82Y30/00B82Y40/00C01P2004/03C01P2004/04C01P2006/12C01P2004/64C01P2004/62
Inventor 郭慧琛茹嘉喜孙世琪张韵白满元尹双辉吴金恩殷宏
Owner LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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