Mixed liquid of chitosan and salvia miltiorrhiza for fallopian tube obstructive infertility and application thereof

A technique for blocking fallopian tubes and chitosan salvia miltiorrhiza, applied in the field of medicine, can solve the problems of limitation, large surgical trauma, inability to identify uterine cavity lesions and deformities by laparoscopy

Inactive Publication Date: 2020-02-14
广州市番禺区中心医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lipiodol angiography doctors and patients need to take pictures under X-ray to observe the diffusion of contrast agent, and need to be exposed to radiation, so the application is limited
Laparoscopy is considered to be the gold standard for judging the patency of the fallopian tubes. However, the operation is traumatic and not only requires the patient to be hospitalized for anesthesia, but also a single laparoscopy cannot determine whether there are lesions or deformities in the uterine cavity. The diagnosis of uterine cavity lesions requires combined hysteroscopy

Method used

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  • Mixed liquid of chitosan and salvia miltiorrhiza for fallopian tube obstructive infertility and application thereof
  • Mixed liquid of chitosan and salvia miltiorrhiza for fallopian tube obstructive infertility and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Example 1: Fallopian tubes are unobstructed: 2D-HyCoSy can show the full range of fallopian tubes, showing continuous band-like high enhancement, continuous and rapid flow of contrast agent can be seen in the lumen, overflow of contrast agent can be seen at the umbrella end, and ring-shaped enhancement can be seen around the ovary of some patients (see figure 1 A), the uterine rectal fossa sees the liquid containing contrast medium or the volume of the original liquid increases. The pelvic contrast agent was evenly diffused. After 3D-HyCoSy reconstruction, it shows that the uterine cavity is well filled, and the fallopian tubes are displayed throughout and run more naturally (see figure 1 B). There was no resistance to the injection of the contrast medium, no reflux of the contrast medium was observed, and the patient had no obvious discomfort.

[0034] figure 1 In middle A, the fallopian tube can be seen in two dimensions, showing continuous band-like high enhanceme...

Embodiment 2

[0035] Example 2: Fallopian tube blockage: in the case of proximal fallopian tube blockage, the fallopian tube near the uterine horn is not displayed or partly displayed, and the distal fallopian tube is not displayed; in the case of distal blockage, most of the proximal end of the fallopian tube is displayed, but the distal expansion is "cystic or Beaded", no contrast medium overflows from the umbrella end, and the intrauterine contrast medium is full and full. After three-dimensional reconstruction, only the uterine cavity and part of the fallopian tubes can be seen (see figure 2 ). Contrast medium bolus resistance is high, and obvious contrast medium reflux is seen.

[0036] figure 2 Middle A is bilateral proximal fallopian tube obstruction, the fallopian tube near the uterine horn is not displayed or partially displayed in three-dimensional view, and the distal fallopian tube is not displayed; figure 2 The middle is bilateral hydrosalpinx, most of the proximal end of...

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Abstract

The invention relates to a mixed liquid of chitosan and salvia miltiorrhiza for fallopian tube obstructive infertility and application thereof. The mixed liquid of chitosan and salvia miltiorrhiza comprises 20 ml of an injection of chitosan and salvia miltiorrhiza and 5 ml of physiological saline. The application includes: firstly injecting about 20 ml of contrast medium for four-dimensional imageacquisition, and then re-injecting 20 ml of physiological saline for dynamic observation of secondary imaging, and the 20 ml of physiological saline used in this process will be mixed with the mixedliquid of chitosan and salvia miltiorrhiza according to a certain proportion to quickly wash the entire fallopian tube and even the pelvis, and the other processes of angiography are no different fromthe current tubal angiography technology. According to the application, the transvaginal four-dimensional hysterosalpingography technology and the mixed liquid of chitosan and salvia miltiorrhiza arecombined, so that a diagnosis method for fallopian tube patency and treatment for fallopian tube infertility can be effectively fused.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a chitosan and salvia miltiorrhiza mixture for tubal obstructive infertility and its application. Background technique [0002] In recent years, due to various factors, the incidence of female infertility has been increasing year by year, and tubal obstruction is the primary cause of female infertility, accounting for about 30%-35%. Although obstetrics and gynecology surgery is gradually developing towards minimally invasive techniques, which reduces abdominal adhesions caused by laparotomy, recent research results show that even the use of microsurgical techniques cannot prevent the formation of tissue adhesions. At present, the commonly used methods for assessing the patency of the fallopian tubes include iodized oil angiography, tubal hydrotubation, and laparoscopy. Lipiodol angiography doctors and patients need to take pictures under X-ray to observe the diffusion of contrast agent, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P15/08A61B8/08A61B8/12A61K31/722
CPCA61B8/12A61B8/481A61K31/722A61K36/537A61P15/08A61K2300/00
Inventor 李偲琦杨鑫黄晨陈汉威刘焕玲陈毓菁唐郁宽黄益
Owner 广州市番禺区中心医院
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