Tetrahydroindoloquinazoline compounds and application thereof

A technology of indoloquinazolines and compounds, applied in the field of tetrahydroindoloquinazolines, capable of solving problems such as low oral bioavailability
CN110790762AActive Publication Date: 2020-02-14MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
Publication Date
2020-02-14

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Abstract

The invention relates to tetrahydroindoloquinazoline compounds and application thereof. Structures of the compounds are shown as a general formula (I) shown in the specification. The compounds are used for (1) preparing medicines for treating cardiovascular and cerebrovascular diseases; (2) preparing preparations for improving the expression of AMPK, ABCA1 and SR-BI; (3) preparing preparations foractivating the activity of a nuclear receptor NR, inhibiting the activity of NLRP3, the activity of IL-1[beta], the activity of NF-[kappa]B and the activity of MAPKs; (4) preparing preparations for promoting outflow of cell cholesterol; and (5) preparing anti-inflammatory medicines.
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Description

technical field

[0001] The invention belongs to the field of medical biotechnology, and specifically relates to a group of tetrahydroindoloquinazoline compounds and applications thereof. Background technique

[0002] Atherosclerosis is a chronic disease characterized by lipid deposition and inflammation, and the inflammation of the vessel wall is an important reason for the development of atherosclerosis (Libby, P., et al., Inflammation inatherosclerosis. Nature, 2002.420 :868-874.). An important basis for inflammatory mediators in the process of atherosclerosis is the modification and deposition of lipids in plaques (Xu, S., et al., Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics. Pharmacology & therapeutics, 2019.196 :15-43.). The early studies of anti-atherosclerotic drugs were mainly characterized by lipid-lowering, and statins were typical representatives. Although statins can effectively lower cholesterol, the effective ...

Claims

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