Preparation method of nano-silver/polydopamine/polypropylene composite patch material

A polydopamine and polydopamine membrane technology, which is applied in the field of medical materials, can solve the problems of inconsistency in the amount of nano silver used, cell damage, etc., and achieves the effects of low cost, favorable tissue growth, and simple production process.

Inactive Publication Date: 2020-02-18
NATONG HORCO N MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some studies have also shown that nano-silver can enter the human body through skin, breathing, oral administration, etc., and participate in blood circulation to reach the heart, kidney, liver, spleen, lungs and other organs of the human body. Normal cells will also be damaged, and there is no consistent conclusion about the amount of nano-silver used. The controllable preparation of nano-silver is of great significance to biological safety and clinical application

Method used

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  • Preparation method of nano-silver/polydopamine/polypropylene composite patch material
  • Preparation method of nano-silver/polydopamine/polypropylene composite patch material
  • Preparation method of nano-silver/polydopamine/polypropylene composite patch material

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Embodiment 1

[0027] 1. Add 100 mg of dopamine to 50 mL of 10 mM Tri-Hcl solution (pH = 8.5), mix and stir, put it into a polypropylene mesh, let it stand for 8 hours in the dark at room temperature, take it out, wash with deionized water and dry.

[0028] 2. Immerse the polydopamine-coated polypropylene mesh in 20mM silver nitrate solution, let it stand for 1h at room temperature and avoid light, then take it out, rinse it with deionized water and remove it in N 2 Blow dry in the atmosphere.

Embodiment 2

[0030] 1. Add 60 mg of dopamine to 50 mL of 10 mM Tri-Hcl solution (pH = 8.5), mix and stir, put it into a polypropylene mesh, let it stand for 16 hours in the dark at room temperature, take it out, wash with deionized water and dry.

[0031] 2. Dip the polydopamine-coated polypropylene mesh into 20mM silver nitrate solution, take it out after 2h, rinse it with deionized water and add it to N 2 Blow dry in the atmosphere.

Embodiment 3

[0033] 1. Add 20 mg of dopamine to 50 mL of 10 mM Tri-Hcl solution (pH = 8.5), mix and stir, put it into a polypropylene mesh, let it stand for 24 hours at room temperature and avoid light, then take it out, wash with deionized water and dry.

[0034] 2. Immerse the polydopamine-coated polypropylene mesh in 20mM silver nitrate solution, take it out after 4h, rinse it with deionized water and put it in N 2 Blow dry in the atmosphere.

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Abstract

The present invention relates to the field of medical materials and particularly to a preparation method of a nano-silver / polydopamine / polypropylene composite patch material. By utilizing characteristics of good adhesiveness, hydrophilicity and biocompatibility of polydopamine, dopamine is oxidized and polymerized into the polydopamine to coat a surface of a polypropylene mesh, so that risks of complications of intestinal adhesion, etc. caused by contact of polypropylene with abdominal organs are reduced. The polydopamine has chelation and reduction characteristics on metal ions and silver ions are reduced into nano-silver to be deposited on a surface of a polydopamine film, so that a microorganism-inhibiting property is obtained. A used technical scheme is as follows: the preparation method comprises the following steps: S1, placing the polypropylene mesh into a dopamine solution for reaction to form a polydopamine film to coat the surface of the polypropylene mesh to obtain a polydopamine / polypropylene composite mesh; and S2, putting the polydopamine / polypropylene composite mesh material into a silver nitrate solution for reaction, and depositing the nano-silver on the surface ofthe polydopamine film to obtain a nano-silver / polydopamine / polypropylene composite patch material which still maintains an original mesh structure and is beneficial to tissue ingrowth and free accesses of macrophages and leukocytes. The manufacturing method is simple and low in cost.

Description

Technical field [0001] The invention relates to the field of medical materials, in particular to a method for preparing a nano-silver / polydopamine / polypropylene composite patch material. Background technique [0002] Tension-free repair surgery is the mainstream for the treatment of hernias, and the number of patches used is increasing year by year. However, related complications have also emerged and are receiving more and more attention. Patch infection is one of the more serious complications, and it is very difficult to deal with. If the patch is removed surgically, it may be difficult and traumatic, which may cause secondary damage to the intestine, spermatic cord, vas deferens, bladder, and other organs, as well as hernia recurrence; if it is simply treated by conventional dressing and drainage and antibiotic treatment, Then the infection may be prolonged and unhealed, facing a long hospital stay, high medical costs, and the possibility of repeated and worsening patient c...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/08A61L31/04A61L31/14A61L31/16
CPCA61L31/048A61L31/088A61L31/10A61L31/14A61L31/146A61L31/16A61L2300/104A61L2300/404A61L2300/606C08L79/02C08L23/12
Inventor 张振东
Owner NATONG HORCO N MEDICAL TECH CO LTD
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