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Composition used for preparing emulsifiable paste, preparation method for composition, and emulsifiable paste capable of warming collaterals and activating blood circulation and prepared from composition

A technology of composition and cream, which is applied in the directions of drug combination, medical preparation containing active ingredients, and ointment delivery, etc., to achieve the effects of improving hand and foot numbness symptoms, improving microcirculation function, and improving blood circulation and blood stasis removal performance.

Inactive Publication Date: 2020-02-21
新疆医科大学第四附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there are still some problems in the efficacy of the Wentong Huoxue Cream of the prior art, which needs further improvement.

Method used

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  • Composition used for preparing emulsifiable paste, preparation method for composition, and emulsifiable paste capable of warming collaterals and activating blood circulation and prepared from composition
  • Composition used for preparing emulsifiable paste, preparation method for composition, and emulsifiable paste capable of warming collaterals and activating blood circulation and prepared from composition
  • Composition used for preparing emulsifiable paste, preparation method for composition, and emulsifiable paste capable of warming collaterals and activating blood circulation and prepared from composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Example 1: Improved Wentong Huoxue Cream

[0062] Weigh 100g of Rhizoma Chuanxiong, 100g of Guizhi, 30g of Safflower, 105g of Angelica dahurica, 55g of Asarum, 25g of Dilong and 55g of pepper.

[0063] Chuanxiong, safflower, cassia twig, and capsicum were refluxed and extracted twice (2 hours each time) in 85% ethanol at 60°C to obtain the concentrated solution of the above-mentioned medicine;

[0064] Asarum, Angelica dahurica, and Earthworm were extracted twice under 70% ethanol reflux at 60°C (2 hours each time) to obtain the concentrated solution of the above-mentioned drugs;

[0065] Get 95g of stearic acid, 52g of glyceryl monostearate, 18g of lanolin, 17g of cetyl alcohol, 17g of stearyl alcohol, 24g of liquid paraffin, and 100g of laurocapram to make it into an oil phase;

[0066] Slowly add the active ingredients and cream excipients into the oil phase at 90°C, and stir at 80°C for 30 minutes to prepare about 1000 g of the improved Wentong Huoxue cream composi...

Embodiment 2

[0067] Embodiment 2: Improved Wentong Huoxue Cream

[0068] Weigh Chuanxiong 100g, Guizhi 100g, Safflower 35g, Angelica dahurica 110g, Asarum 60g, Dilong 30g and Capsicum 50g.

[0069] Chuanxiong, safflower, cassia twig, and pepper were refluxed and extracted twice (2 hours each time) in 85% ethanol at 65°C to obtain the concentrated solution of the above-mentioned medicine;

[0070] Asarum, Angelica dahurica, and Earthworm were extracted twice at 65°C in 70% ethanol under reflux (2 hours each time) to obtain the concentrated solution of the above-mentioned drugs;

[0071] Get 95g of stearic acid, 52g of glyceryl monostearate, 18g of lanolin, 17g of cetyl alcohol, 17g of stearyl alcohol, 24g of liquid paraffin, and 100g of laurocapram to make it into an oil phase;

[0072] Slowly add the active ingredients and cream excipients into the oil phase at 90°C, and stir at 80°C for 30 minutes to prepare about 1000 g of the improved Wentong Huoxue cream composition.

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Abstract

The invention relates to a composition used for preparing an emulsifiable paste, a preparation method for the composition, and the emulsifiable paste capable of warming collaterals and activating blood circulation and prepared from the composition. The composition used for preparing the emulsifiable paste comprises the following components: 90 to 110 parts by weight of rhizoma chuanxiong, 90 to 110 parts by weight of cassia twig, 25 to 35 parts by weight of safflower, 100 to 110 parts by weight of radix angelicae dahuricae, 50 to 60 parts by weight of asarum, 20 to 30 parts by weight of earthworm and 50 to 60 parts by weight of chili. The emulsifiable paste capable of warming collaterals and activating blood circulation has better performances of activating blood circulation and removing blood stasis, better improve the functions of microcirculation, and can better improve hand and foot numbness symptoms of a patient.

Description

technical field [0001] The present disclosure relates to a cream composition, and more specifically, the present disclosure relates to a composition for preparing cream, a preparation method thereof, and a Wentong Huoxue cream prepared therefrom. Background technique [0002] Diabetic peripheral neuropathy (DPN) is a relatively common chronic complication of diabetes. Distal symmetrical polyneuropathy is the most common. The main clinical manifestations are numbness, pain, hyperalgesia, and muscle weakness. Pain has caused serious harm to the quality of life of diabetic patients. In severe cases, major injuries such as foot ulcers, gangrene, and even amputation may occur. This disease not only increases the mortality and mortality of diabetic patients, but also increases social, family and patient burden. The cause of its pathogenesis has not been fully elucidated, and it is currently believed that oxidative stress is closely related to the occurrence and development of chr...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61K9/06A61P9/14A61P29/00A61K35/62
CPCA61K9/0014A61K9/06A61K35/62A61K36/232A61K36/236A61K36/268A61K36/286A61K36/54A61K36/81A61K47/44A61P9/14A61P29/00A61K2300/00
Inventor 李凯利马丽陈茜王卫群李晶冯程程
Owner 新疆医科大学第四附属医院
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