Preparation method and application of algin polysaccharide sulfate capsules
A fucoidan and sulfate technology is applied in the directions of capsule delivery, medical preparations containing active ingredients, pharmaceutical formulations, etc. Good results
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experiment example 1
[0021] Experimental example 1 preparation method compares
[0022] 1. Experimental method: Carry out the comparison of three preparation methods with the same ratio of auxiliary materials (corn starch 40g, microcrystalline cellulose 110g and 20% fucoidan sulfate solution 250ml)
[0023] Experimental group 1: take excipients, 20% sugar solution for boiling granulation, and fill capsules.
[0024] Experimental group 2: Mix the main drug fucoidan sulfate with auxiliary materials, and directly fill capsules.
[0025] Experimental group 3: take the main drug fucoidan sulfate and auxiliary materials, use ethanol aqueous solution as a binder, and carry out wet granulation.
[0026] 2. Experimental results:
[0027] The results are shown in Table 1. The results show that the capsules prepared by boiling granulation have good fluidity and good content uniformity in the filling process; the powder is directly filled into capsules, the filling process is more dusty, and the content un...
experiment example 2
[0030] Experimental example 2 Fan speed investigation
[0031] Get the auxiliary materials of the same conditions in Experimental Example 1 and add them to the boiling granulator for boiling. During the spraying process of the sugar solution, the wind speed is adjusted. Set the fan frequency according to Table 2 to adjust the fan speed. For other process parameters, refer to method 1. The wind speed has a great influence on boiling granulation, so it needs to be investigated. The wind speed changes with the change of the fan frequency, so the wind speed is inspected through the fan. to change the frequency. The inspection results are shown in Table 2.
[0032] The results show that in the case of the same raw materials, the wind speed will significantly affect the granulation effect during the granulation process; if the wind speed is too high or too low, the granulation effect will be poor. When the fan frequency is 30-45Hz, the wind speed is appropriate and the auxiliary ma...
experiment example 3
[0036] The investigation of experimental example 3 sugar concentration (binder) adding amount
[0037] Take method 1 for boiling granulation, add different concentrations of sugar solutions of fucoidan sulfate prepared with purified water according to the ratio in Table 3, which also has the function of binder, and refer to method 1 for other process parameters.
[0038] The results are shown in 3. The results show that the concentration of sugar solution is high, the amount of water is small, and the granulation is poor. When the concentration is 15-25%, when the mass ratio of excipients and sugar solution is 90-225%, the granulation effect is better.
[0039] The investigation result of table 3 sugar concentration
[0040] Sugar concentration% Granulation effect 10 The amount of water is more, and the particles can be prepared, but the preparation time is longer, and the particle size is larger 15 Can complete granulation, good particle size uniformit...
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