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Water-in-oil-system breast enhancement polypeptide composition

A technology of polypeptide composition and water-in-oil, which is applied in the direction of cosmetics, cosmetic preparations, dressing preparations, etc., and can solve the problems of rising costs, harm, and increasing the amount of input

Pending Publication Date: 2020-02-28
宇肽生物(东莞)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, peptides are prone to degradation in aqueous solution, and the peptide components are directly added to water-based products. The resulting problem is that the stability of the peptides in the product is poor, so that the peptides with high-efficiency activities cannot give full play to their due potential. effect, and the degradation products produced by the degradation of the peptide in the product may cause potential harm to the human body
In addition, water-soluble substances are difficult to be absorbed through the skin barrier, so it is difficult to give full play to their breast enhancement effect
In order to increase transdermal absorption and achieve the desired effect, it is necessary to increase the amount of feed, which will lead to an increase in cost

Method used

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  • Water-in-oil-system breast enhancement polypeptide composition
  • Water-in-oil-system breast enhancement polypeptide composition
  • Water-in-oil-system breast enhancement polypeptide composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-5 and comparative example 1-5

[0053] The preparation method of embodiment 1-5 and comparative example 1-5 composition:

[0054] 1. Accurately weigh raw materials 5, 6, 7, 8, and 9, add the prescribed amount of raw material 1, and fully dissolve;

[0055] 2. Accurately weigh raw materials 2, 3, and 4, and mix them with the solution obtained in step 1 to get ready. Adopt biological digital microscope to observe the microscopic image of embodiment 2, the results are shown in figure 1 , Many small droplets of uniform size were observed under the microscope at 40*10 times, evenly distributed in the oil phase, forming a water-in-oil system.

Embodiment 1-5、 comparative example 1-5

[0061] 1.3 Test basis

[0062] "Chinese Pharmacopoeia" 2015 Edition Four General Rules 9001 Guiding Principles for Stability Testing of APIs and Preparations

[0063] 1.4 Test conditions and inspection items

[0064] Accelerated test: Constant temperature and humidity chamber at 40°C±2°C, RH75%±5%, respectively, at the first, second, third, and sixth month, detect the peptide content in each sample by HPLC to evaluate its stability.

[0065] Long-term test: Constant temperature and humidity chamber at 25°C±2°C, RH60%±10%, at the 3rd, 6th, 9th, 12th, 18th, 24th, and 36th month respectively, detect the peptide content in each sample by HPLC to evaluate its stability.

[0066] 1.5 Stability test results

[0067] After the samples of Examples 1-5 and Comparative Examples 1-5 were placed under accelerated test conditions for 6 months, the stability data are shown in the following table 1:

[0068] Table 1 accelerates the stability test data of 6 months (content should be 95%-10...

Embodiment 1、 comparative example 1

[0080] 2.3 Test method

[0081] The transdermal properties of the samples were evaluated by vertical Franz diffusion cell method. Fix the isolated skin of SD rat abdomen between the receiving chamber and the supplying chamber of the diffusion cell, take 1g sample on the skin surface of the supplying chamber, the effective diffusion area is 3.14cm 2 , add physiological saline to the receiving tank as the receiving solution, drain the air bubbles so that the side of the dermis is in complete contact with the receiving solution, stir and diffuse at 32°C and 300r / min. Take 0.5mL of receiving solution at 4h, 8h, 12h, 16h, 20h, and 24h respectively, and add an equal amount of constant temperature blank receiving solution in time. The concentration of the polypeptide in the receiving solution was measured by HPLC, and the cumulative transdermal amount of the polypeptide per unit area at different times was calculated according to the following formula:

[0082]

[0083] Among th...

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Abstract

The invention discloses a water-in-oil-system breast enhancement polypeptide composition and belongs to the technical field of beautifying polypeptides. The water-in-oil-system breast enhancement polypeptide composition comprises polypeptides for promoting adipose tissue growth and one or more of polypeptides with a repairing function, wherein the polypeptides exist in water phase, the mass percentage concentration of the polypeptides is 0.0001-5%, and the water phase and oil phase form a water-in-oil system; the oil phase comprises a surfactant and an oily emollient. Compared with a water-based-system composition, the water-in-oil-system breast enhancement polypeptide composition has the advantages that the water-in-oil system is adopted, the polypeptides are dissolved in a small amount of water phase, higher local polypeptide concentration in the water-in-oil system is achieved, transdermal absorption of the polypeptides can be achieved easily, high polypeptide accumulation quantityon the skin can be achieved, and a better breast enhancement effect can be achieved by the same polypeptide feeding quantity; in addition, the water-in-oil-system breast enhancement polypeptide composition is good in stability, high in safety, simple in preparation process, low in cost and suitable for large-scale industrial production.

Description

technical field [0001] The invention belongs to the technical field of cosmetic polypeptides, and relates to a water-in-oil system breast-enhancing polypeptide composition. Background technique [0002] With the improvement of living standards, people pay more and more attention to physical beauty. For women, breast beauty is an important part of physical beauty. Many women pay attention to their breasts and hope to have a firm and full breast. There are many products for breast enhancement on the market at present, and natural breast enhancement preparations are sought after by consumers because of their naturalness. [0003] Natural breast enhancement preparations are divided into sex hormones, phytoestrogens and products that act on adipose tissue. Among them, the breast enhancement preparations of sex hormones mainly promote the growth of female breasts through the joint action of estrogen or estrogen and progesterone, and its side effects may lead to excessive hyperpla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/06A61K8/37A61K8/64A61K8/81A61K8/92A61Q19/00
CPCA61K8/64A61K8/922A61K8/8111A61K8/37A61K8/375A61K8/064A61Q19/00
Inventor 丁文锋彭晏黄春青
Owner 宇肽生物(东莞)有限公司
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