Preparation method of large-steric-hindrance alkyl substituted phosphite diester

Abstract

The invention discloses a preparation method of large-steric-hindrance alkyl substituted phosphite diester, and relates to a novel method for preparing the large-steric-hindrance alkyl substituted phosphite diester compound which is difficult to synthesize by a known method through direct reaction of large-steric-hindrance alcohols and triphosphite by using trifluoromethanesulfonic acid trimethylsilyl ester as a catalyst. Therefore, the method can be a breakthrough for synthesizing the large-steric-hindrance alkyl substituted phosphite diester compound by an Arbuzov method, and is an improvedArbuzov method with high universality due to the fact that the method is also suitable for common primary alcohol raw materials. Specifically, according to the method, stable and low-toxicity large-steric-hindrance alcohols are used as raw materials; the method has the advantages of simple reaction conditions, easy operation and no need of a solvent, no transition metal is contained in the catalyst, the product has no transition metal residual hidden trouble, the byproduct is micromolecular alcohols such as ethanol, and almost no toxicity exists, so the method is a green synthesis method of large-steric-hindrance alkyl substituted diphosphite, and has good research value and synthesis application prospect.

Description

technical field [0001] The invention belongs to the technical field of organic chemical synthesis, and in particular relates to a green product which directly reacts bulky hindered alcohols and phosphite triesters under the catalysis of trimethylsilyl trifluoromethanesulfonate to prepare bulky hindered alkyl-substituted phosphonites. resolve resolution. Background technique [0002] Organophosphorus compounds containing C-P(O) bonds have extensive and important applications in the fields of medicine and agriculture, as well as in organic synthesis and catalysis. [0003] The famous Arbuzov (Arbuzov) reaction, through the reaction of halogenated alkanes and phosphite triesters under high temperature heating to generate C-P (O) compounds, is an important classic method for the synthesis of organic phosphonite derivatives, in the laboratory and It is widely used in the industry to manufacture various organic phosphine compounds. But the shortcoming of this reaction is also ob...

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Problems solved by technology

Although the use of alcohols instead of halogenated hydrocarbons has certain advantages, there are still key shortcomings in these methods that have not been overcome. For example, these methods are limited to primary alcohols and are not suitable for large sterically hindered secondary alcohols and tertiary alcohols. ZnBr 2 , ZnI 2 、PPh 3 Reagents such as / DDQ not only produce a large amount of difficult-to-handle waste and pollute the environment, but in fact these methods include the process of converting alcohols into halogenated alkanes on site, which is not much improved compared with the method of directly using only halogenated alkanes

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