A probiotic composition for post-gastrectomy treatment and preparation method thereof

A composition and probiotic technology, applied in the field of microorganisms, can solve the problems of difficult to achieve inflammation treatment effect, complicated production and preparation, and untargeted target

Active Publication Date: 2020-09-25
哈尔滨美华生物技术股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it involves immune proteins, which are relatively complicated in production and preparation.
And the compositions in this invention are of a wide variety, and the objects of action are not targeted, so it is difficult to achieve the best therapeutic effect on inflammation in different parts

Method used

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  • A probiotic composition for post-gastrectomy treatment and preparation method thereof
  • A probiotic composition for post-gastrectomy treatment and preparation method thereof
  • A probiotic composition for post-gastrectomy treatment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0115] Basic experiment example 1: Screening of intestinal probiotics in cancer-free villages

[0116] (1) Feces collection, processing and intestinal microbial isolation and screening (all volunteers’ written consent was obtained before collection)

[0117] The first morning fecal samples were collected from healthy volunteers in Wuyuan Cancer-free Village (healthy people with normal diet and no cancer), patients with gastric cancer and patients with gastrectomy for gastric cancer (the Second Affiliated Hospital of Nanchang University) (without taking antibiotics within three months, non- Vegetarians), immediately transferred to a sealed anaerobic plastic bag (85% N 2 , 5%H 2 , 10% CO 2 ) placed for one hour, then weighed 10g of feces samples into a 10mL centrifuge tube with built-in sterilized glycerin, the glycerin content was 10% of the sample, and sealed the centrifuge tube mouth with sealing glue (the above operations were completed in the anaerobic bag). Quickly stor...

Embodiment 1

[0140] Example 1 Animal experiments evaluating the effects of probiotic compound preparations on intestinal inflammation and intestinal barrier after gastric cancer surgery in rats

[0141] (1) Animal experiment grouping, modeling and specimen collection

[0142] 1) Animal grouping: 48 SPF male SD rats, aged 6-7w, with a body weight of 140-180g, were randomly divided into 4 groups: control group (group C), model group (group M), low-concentration probiotic treatment group (LT group), high-concentration probiotics treatment group (HT group), 12 rats in each group.

[0143] 2) Model construction:

[0144] ①Gastric cancer model construction:

[0145] Except for the routine feeding of the blank control group, the rats in other groups drank freely with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) solution, wherein the concentration of MNNG was 150 μg / mL; 2% water Gastrointestinal administration of sodium salicylate solution 1 time / day, 2 mL / time, or 1 time / day, 0.5 mL / time at 55°...

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Abstract

The present invention provides a probiotic composition for treatment after gastrectomy, the composition of which includes one or more of Lactobacillus plantarum, Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium animal, and Its application as medical preparations, food and health products for post-gastrectomy treatment is provided. The invention also provides a production and preparation method of the probiotic composition. The probiotics selected by the invention have good safety, strong pertinence, no toxic and side effects, low price and can realize industrial production.

Description

technical field [0001] The invention belongs to the technical field of microbes, and in particular relates to a probiotic composition for treatment after gastrectomy and a production and preparation method thereof. Background technique [0002] Gastric cancer is one of the common malignant tumors of the upper gastrointestinal tract. 90% of gastric cancer patients are advanced gastric cancer. Although comprehensive treatment is currently used, the prognosis is still unsatisfactory 1 . At present, comprehensive treatment based on radical resection is the main mode of treatment for advanced gastric cancer. Surgery improves the survival rate, but surgical trauma stress, inflammatory response, and a series of pathophysiological changes caused by surgery seriously affect the postoperative recovery of patients . The latest research shows that reducing the postoperative stress and inflammatory response of patients can promote early recovery of patients, thereby improving the long-...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A61K35/747A61K35/745A61P29/00A61P1/00A61P1/10A61P1/12A61P1/08A61P1/14A61P25/18A61P3/10A61P9/12A61P25/16A23L33/135C12R1/25C12R1/225C12R1/23C12R1/01
CPCC12N1/20A61K35/747A61K35/745A61P29/00A61P1/00A61P1/10A61P1/12A61P1/08A61P1/14A61P25/18A61P3/10A61P9/12A61P25/16A23L33/135A23V2002/00C12R2001/225C12N1/205C12R2001/25A23V2400/113A23V2400/175A23V2400/515A23V2400/169A23V2200/3202A23V2200/328A23V2200/326A23V2200/322A23V2200/324A23V2200/332
Inventor 陈廷涛肖雯娟林枫翔侯莹秦琦
Owner 哈尔滨美华生物技术股份有限公司
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