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Gel for skin wound repair

A skin wound and gel technology, applied in the field of life sciences, can solve problems such as nicotinamide mononucleotide that have not yet been discovered, and achieve the effects of increasing capillaries and fibroblasts, rapid regeneration, and promoting proliferation

Inactive Publication Date: 2020-04-10
崔立峰 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about nicotinamide mononucleotide in skin wound repair in the literature

Method used

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  • Gel for skin wound repair
  • Gel for skin wound repair
  • Gel for skin wound repair

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0016] Hydroxyethyl cellulose was selected as the hydrogel matrix and nicotinamide mononucleotide was added to treat diabetic skin wound model mice. The wound repair was monitored, and the effect of nicotinamide mononucleotide gel on skin wounds was comprehensively analyzed Repair effect. The prepared gel containing nicotinamide mononucleotide and other antibacterial drugs was tested for therapeutic application on skin wounds of more than 20 cases of diabetics and normal patients, and it was found that it has a significant effect in promoting wound healing.

[0017] Case 1,

[0018] control group

[0019] 1. Gel preparation: select hydroxyethyl cellulose (viscosity of 800-1500mPa.s) as the hydrogel matrix, boil and sterilize for 30min, and prepare 2% gel at 20°C.

[0020] 2. Establishing a skin wound model of diabetic mice: Type II diabetic Leprdb / db genotype mice (20) were selected and treated with phosphate buffered saline (PBS solution) as a control group. Establish the ...

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Abstract

The invention discloses a gel for skin wound repair. The gel comprises a hydrogel matrix, wherein the hydrogel matrix is boiled and sterilized for 30 min so as to prepare a gel with a concentration of2% at 20 DEG C, and then nicotinamide mononucleotide is added so as to prepare the gel with a concentration of 2-6. Compared with the prior art, the gel has the advantages that the gel can rapidly repair a diabetic wound surface, is high in pertinence and remarkable in curative effect, and allows a wound to be quickly healed.

Description

technical field [0001] The invention relates to the technical field of life sciences, in particular to a gel for repairing skin wounds. Background technique [0002] Diabetes is one of the major diseases that threaten human beings. Poor wound healing is a complication of diabetes, which may lead to amputation in severe cases, and has become the disease with the highest hospitalization rate for diabetic patients. Diabetic ulcer is one of the common complications of diabetes. It is a difficult clinical problem and one of the current research hotspots in trauma medicine. Due to the high blood sugar and low immunity of diabetic patients, the wounds, incisions and sores of diabetic patients do not close for a long time and are difficult to heal. At present, most of the treatment methods are to treat wound healing by taking hypoglycemic western medicine, taking insulin, or injecting antibiotics, combined with external Chinese medicine, but the curative effect is not significant e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/706A61K45/06A61K31/7052A61P3/10A61P17/02
CPCA61K9/0014A61K9/06A61K31/7052A61K31/706A61K45/06A61P3/10A61P17/02A61K2300/00
Inventor 崔立峰张培华陈豪登方鹏斌
Owner 崔立峰
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