A supercritical co 2 Extracted Entrained Pharmaceutical Methods

Abstract

The invention discloses a new type of entrainment pharmaceutical method based on supercritical CO2 extraction, which belongs to the technical field of supercritical pharmaceuticals, and can realize that most of the entrainer is injected into the centrifugal slow-release ball through a new type of entrainer mixing method, and less Part of it is pre-mixed with supercritical CO2. During the extraction, the injected entrainer is slowly released into the medicinal powder and fully contacted by extrusion through centrifugal rotation. At the same time, the medicinal powder is driven to turn over continuously. The reaction is fully and comprehensively carried out under the atmosphere, which significantly strengthens its extraction performance and improves its extraction efficiency. At the same time, it enhances the solubility of the active ingredients in the medicinal material and the sensitivity to temperature and pressure, so that the separated components can be separated from the circulating gas through temperature and pressure. Separated to avoid the high energy consumption of gas recompression, it can even be used as a co-surfactant to facilitate the formation of supercritical fluid microemulsion, which has great advantages in extracting biologically active components in medicinal materials.

Description

technical field [0001] The invention relates to the technical field of supercritical pharmacy, more specifically, to a method based on supercritical CO 2 Extraction of Entrained Pharmaceutical Methods. Background technique [0002] Supercritical fluid extraction is a new type of extraction and separation technology. It uses a supercritical fluid, that is, a fluid in a thermodynamic state with a temperature higher than the critical temperature and a pressure higher than the critical pressure, as the extraction agent. Extract specific components from liquids or solids for separation purposes. The characteristics of supercritical fluid extraction are: the extractant is a gas at normal pressure and room temperature, and it is easy to separate from the raffinate phase and extraction group after extraction; it operates at a lower degree of surplus, which is especially suitable for the separation of natural substances; the pressure can be adjusted Adjust the dissolving ability o...

AI Technical Summary

Problems solved by technology

However, it was also found that supercritical CO 2 Extraction technology still exists: operating pressure is big, extraction time is long, the requirement to equipment is higher, energy consumption is relatively large, extraction capacity is small, extraction rate is not ideal and so on. The extraction process is strengthened, which can effectively increase the extraction yield and reduce the operating pressure, etc.

[0004] The change rule of entrainer property to extraction rate is: the molecular polarity of entrainer is bigger, and solute is in supercritical CO 2 The greater the solubility in the entrainer; the increase in the relative molecular mass or molecular volume of the entrainer, which in supercritical CO 2 The solubility in the medium decreases, and the extraction rate decreases; the entrainer molecules that are easy to form hydrogen bonds can significantly increase the extraction rate; the entrainer of multiple (mixed) components can improve the extraction efficiency more significantly, but in the prior art, more use The entrainer directly interacts with CO 2 pumped together for extraction, and due to the CO 2 The flow rate is fast, and the entrainer has already flowed away before it can fully contact with the material, resulting in an effective improvement of the extraction performance, requiring a large amount of entrainer, and the extraction efficiency is low

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