A supercritical co 2 Extracted Entrained Pharmaceutical Methods

A supercritical and extraction technology, applied in separation methods, solvent extraction, solid solvent extraction, etc., can solve the problems of entraining agent consumption, small extraction capacity, and reduced extraction rate, and achieve the effect that is conducive to deformation and shrinkage

CN111013188BActive Publication Date: 2021-06-25JIANGSU GAOKE PHARM EQUIP CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Publication Date
2021-06-25

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Abstract

The invention discloses a new type of entrainment pharmaceutical method based on supercritical CO2 extraction, which belongs to the technical field of supercritical pharmaceuticals, and can realize that most of the entrainer is injected into the centrifugal slow-release ball through a new type of entrainer mixing method, and less Part of it is pre-mixed with supercritical CO2. During the extraction, the injected entrainer is slowly released into the medicinal powder and fully contacted by extrusion through centrifugal rotation. At the same time, the medicinal powder is driven to turn over continuously. The reaction is fully and comprehensively carried out under the atmosphere, which significantly strengthens its extraction performance and improves its extraction efficiency. At the same time, it enhances the solubility of the active ingredients in the medicinal material and the sensitivity to temperature and pressure, so that the separated components can be separated from the circulating gas through temperature and pressure. Separated to avoid the high energy consumption of gas recompression, it can even be used as a co-surfactant to facilitate the formation of supercritical fluid microemulsion, which has great advantages in extracting biologically active components in medicinal materials.
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Description

technical field

[0001] The invention relates to the technical field of supercritical pharmacy, more specifically, to a method based on supercritical CO 2 Extraction of Entrained Pharmaceutical Methods. Background technique

[0002] Supercritical fluid extraction is a new type of extraction and separation technology. It uses a supercritical fluid, that is, a fluid in a thermodynamic state with a temperature higher than the critical temperature and a pressure higher than the critical pressure, as the extraction agent. Extract specific components from liquids or solids for separation purposes. The characteristics of supercritical fluid extraction are: the extractant is a gas at normal pressure and room temperature, and it is easy to separate from the raffinate phase and extraction group after extraction; it operates at a lower degree of surplus, which is especially suitable for the separation of natural substances; the pressure can be adjusted Adjust the dissolving ability o...

Examples

Embodiment 1

[0049] see figure 1 , a supercritical CO based 2 A method of extracting entrained pharmaceuticals comprising the steps of:

[0050] S1. After weighing the medicinal material to be extracted, grinding and pulverizing, take a part of the total amount of entraining agent and inject it into the centrifugal slow-release ball, and then put the medicinal material into the extraction kettle and mix it with the centrifugal slow-release ball;

[0051] S2, use the booster pump to remove the CO in the gas storage tank 2 After being heated by the heater, it enters the supercritical state, pumps it into the premixer and mixes it well with the remaining entrainer, then opens the valve and enters the extraction kettle;

[0052] S3, control supercritical CO 2 The flow rate is 5-10L / h, the extraction temperature is 35°C-50°C, the extraction pressure is 10-25MPa, and an external uniformly changing rotating magnetic field is applied to the extraction kettle to force the centrifugal slow-releas...