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Extraction method of traditional Chinese medicine volatile components

A technology of volatile components and extraction methods, which is applied in the field of extraction of volatile components of traditional Chinese medicine, can solve the problems of different components, unsatisfactory, difficult to collect volatile oil, etc., and achieve the effect of ensuring safety and effectiveness

Inactive Publication Date: 2020-04-24
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 2. Long-term high-temperature distillation will damage the ingredients themselves, and the quality of its preparations is different from that of traditional decoctions
[0009] 3. Some varieties are difficult to distill and separate to collect volatile oil
Due to different physical and chemical properties, the volatile oils exhibit various characteristics. For example, the relative density of the volatile oils of Angelica and Chuanxiong is basically the same as that of water, and it is difficult to collect them in layers after standing for a long time. Ideal, but also for volatile oils that are partially dissolved in water and cannot be collected by physical layering
[0010] 4. Add an organic solvent to the distillate for extraction, then condense and volatilize the organic solvent to collect the volatile oil, but some volatile components that are consistent with the distillation range of the organic solvent will also be lost with the volatilization of the organic solvent, and at the same time bring the residue of the organic solvent to cause the product Potential Hazards to Safety
[0011] 5. Supercritical extraction of volatile oil is used. In fact, the extracted substance is not pure volatile oil, but a type of fat-soluble component soluble in non-polar liquid carbon dioxide. The components in the solution are different, without clinical research or long-term drug practice, it will inevitably bring about safety and effectiveness issues

Method used

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  • Extraction method of traditional Chinese medicine volatile components
  • Extraction method of traditional Chinese medicine volatile components

Examples

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Effect test

Embodiment 1

[0058] The present embodiment is the extraction of the volatile components of Angelica sinensis, and the steps are as follows:

[0059] (1) Take 20kg of angelica, add 180L of water, soak for 30 minutes, heat and decoct for 30 minutes, filter the decoction, add 140L of medicinal residues, heat and decoct for 20 minutes, filter and decoct, and combine the decoction, about 240L in total , the water decoction is evaporated under reduced pressure at a vacuum degree of -0.076Mpa and a temperature of 65°C to obtain about 200L of evaporated liquid;

[0060] (2) carry out reverse osmosis concentration to the evaporated liquid of step (1) gained: adopt the DCC100 type reverse osmosis membrane of inorganic ceramic membrane material, the pressure in the reverse osmosis membrane is 16kg / m 2 , the vacuum outside the reverse osmosis membrane is -0.02Mpa, and the reverse osmosis temperature is controlled at 25°C; 1.2L of reverse osmosis concentrate containing volatile components of angelica i...

Embodiment 2

[0069] Zhishi Xiebai Guizhi Decoction is a traditional classic recipe, which is recorded in "Synopsis of the Golden Chamber". ), mainly treats thoracic obstruction and heart distension, leaving Qi stagnation in the chest, chest fullness, hypochondrium and robbing the heart. The decoction method is: add the five flavors, take five liters of water, first boil the citrus aurantium and Magnolia officinalis, take two liters, remove the water, boil all the medicines, boil for a few times, and take three times at different temperatures. This prescription is a qi regulating agent, and the volatile components are the main functional components of this prescription. Therefore, if this prescription is prepared into a modern preparation, collecting the volatile oil and ensuring that it is consistent with the original decoction components is the key to the technology.

[0070] This example is the extraction of volatile components of Zhishi Xiebai Guizhi Decoction, the steps are as follows:...

Embodiment 3

[0082] Juanbi Decoction is contained in "Medical Mind Wu", the original prescription is: Notopterygium, Duhuo 1 qian each, Guixin 5 fen, Gentiana chinensis 1 qian, Angelica 3 qian, Ligusticum chuanxiong 7 fen, Licorice 5 fen (burned), Caulis 2 qian , three qian of mulberry branches, frankincense, and woody incense each eight points, decocted in water, to treat wind, cold, and dampness, and combine to form numbness. This prescription is a dehumidifying agent, using Qianghuo, Duhuo, Guixin, Gentiana, Caulis Caulis, and Mulberry Branch to dispel wind and dampness and dispel cold, together with Angelica, Chuanxiong, and frankincense to promote blood circulation and relieve pain, promote blood circulation and remove wind, cold and dampness. Among them, Qianghuo, Duhuo and Angelica , Chuanxiong, frankincense, and woody all contain volatile oil, which promotes blood circulation and qi and relieves pain, and volatile oil is the main functional ingredient of this prescription. The key ...

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Abstract

The invention relates to an extraction method of traditional Chinese medicine volatile components. The extraction method of traditional Chinese medicine volatile components comprises the following steps: taking traditional Chinese medicinal materials or traditional Chinese medicine preparations containing volatile components, and carrying out at least one time of water adding decocting to obtain awater decoction containing the volatile components; and carrying out reduced pressure evaporation on the water decoction containing the volatile components, and collecting an evaporated liquid. The extraction method can effectively avoid the situation that volatile components are damaged and are inconsistent with components in a decoction in a traditional extraction method, and is suitable for traditional Chinese medicinal material varieties which are difficult to distill, separate and collect the volatile components. Meanwhile, no extra impurity component is introduced, so that the product safety and effectiveness are guaranteed.

Description

technical field [0001] The invention relates to the technical field of extraction of traditional Chinese medicinal materials, in particular to a method for extracting volatile components of traditional Chinese medicinal materials. Background technique [0002] Volatile components are a kind of ingredients in traditional Chinese medicine with various physiological functions, and they account for a large proportion in traditional Chinese medicine. direct material source. Volatile components are usually the main active ingredients in medicines for treating the exterior, aromatizing dampness, regulating qi, rejuvenating aromatics, warming the interior, and promoting blood circulation. Such as Xinwenjie external medicine ephedra, cassia twig, perilla leaf, ginger, coriander, Nepeta, Fangfeng, Qianghuo, Angelica dahurica, Asarum, Ligusticum edulis, magnolia, scallion white, goose does not eat grass; Chrysanthemum, Vitex, Bupleurum, Peucedanum; heat-clearing and detoxifying medic...

Claims

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Application Information

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IPC IPC(8): A61K36/00A61K36/232A61K36/8962A61K36/67A61K47/69
CPCA61K36/00A61K36/232A61K36/236A61K36/237A61K36/285A61K36/324A61K36/428A61K36/484A61K36/515A61K36/54A61K36/575A61K36/605A61K36/67A61K36/752A61K36/8962A61K2236/331A61K2236/51A61K47/6951A61K2300/00
Inventor 刘燎原曾昭君鲁云干丽张正张志鹏方朝缵
Owner GUANGDONG YIFANG PHARMA
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