Multi-degree-of-freedom self-assembly nano-robot and manufacturing control method thereof

A technology of nano-robots and control methods, applied in the field of multi-degree-of-freedom self-assembled nano-robots and their production control, can solve problems such as the inability to detect effective features of single molecules, and achieve the effect of precise control

Active Publication Date: 2020-04-28
SOUTHEAST UNIV
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  • Claims
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Problems solved by technology

[0004] In the existing nanopore single-molecule sensors, the molecules to be detected cannot be stably, continuously and controllabl

Method used

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  • Multi-degree-of-freedom self-assembly nano-robot and manufacturing control method thereof

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Embodiment Construction

[0038] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in combination with specific examples and with reference to the accompanying drawings.

[0039] Such as figure 1 As shown, the self-assembled nano-robot of the present invention is composed of micro-nano particles 3 and four deoxyribonucleic acid chains 4, and its specific layout can be found in figure 1 shown. The silicon-based film 1 for the nano-robot to walk is respectively processed with nanoholes 2 and nano-gold electrodes 5 on the vertices of a square on the silicon-based film 1 .

[0040] The ends of the four deoxyribonucleic acid chains 4 are modified with sulfhydryl groups or biotin, while the surface of the micro-nanoparticles 3 is coated with a gold film or streptavidin, through the strong interaction between gold-sulfhydryl bonds or streptavidin and biotin The function binds the deoxyribonucleic a...

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Abstract

The invention relates to a multi-degree-of-freedom self-assembly nano-robot and a manufacturing control method thereof. The nano-robot is a quadruped nano-robot formed by self-assembly of micro-nano particles and four desoxyribonucleic acid chains through strong interaction of gold-mercapto bonds or streptavidin and biotin under mutual effects. Round gold electrodes are deposited at the four vertexes of a square on a silicon-based material respectively, and four nanopores are machined in the round gold electrodes at the same time; and under the sizes of the nanopores, each nanopore can captureonly one desoxyribonucleic acid chain under the action of an external electric field. The nanogold electrode is connected with an external voltage source; the electrical property and strength of charge density on the nanopore can be regulated and controlled by regulating and controlling the direction and size of voltage on each nanopore, so that the direction and strength of electroosmotic flow passing through the nanopore are controlled and combined or competitive drive is formed by the electric field force borne by the desoxyribonucleic acid chain and thus the movement speed and direction of the nano robot are controlled.

Description

technical field [0001] The invention relates to a combined driving technology of electroosmosis and electrophoresis based on nanopores; in particular, it relates to a multi-degree-of-freedom self-assembled nanorobot and a production control method thereof. Background technique [0002] Based on nanopore single-molecule detection technology, the best state of detection is that the molecule to be tested can be stably in the nanopore for a long time, and the molecule to be tested can be controlled to repeatedly enter and exit the nanopore to achieve repeated measurements and reduce the detection error rate. At present, common single-molecule manipulation techniques include atomic force microscopy (AFM), optical tweezers, and magnetic tweezers. For example, the molecule to be tested can be assembled and combined with the AFM probe (or micro-nanoparticle) through the gold-sulfhydryl bond (or the strong interaction of biotin-streptavidin), but the AFM probe cannot scan the nanopor...

Claims

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Application Information

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IPC IPC(8): G01N27/00G01Q60/24B82Y40/00
CPCG01N27/00G01Q60/24B82Y40/00
Inventor 司伟陈畅孙倩怡余梦沙菁章寅陈云飞
Owner SOUTHEAST UNIV
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