Method for dynamically measuring cerebral oxygen metabolism rate

Abstract

The invention discloses a method for dynamically measuring cerebral oxygen metabolism rate. According to the method, a perfusion multiecho asymmetric spin echo technology are adopted, namely, a multiecho signal acquisition mode formed by alternately switching a layer selection inversion mark and a non-layer selection inversion mark is adopted, oxygen extraction fraction (OEF) and cerebral blood flow (CBF) weighted images are synchronously obtained in a mode of adding / subtracting layer selection signals and non-layer selection signals, and measurement of dynamic change of the cerebral metabolicrate of oxygen (CMO2) is finally realized by combining Fick's law. According to the invention, a series of problems caused by gas calibration required by calibrating a blood oxygen level dependent (BOLD) method are fundamentally solved, so that the comfort level of a subject is greatly improved, the applicable population is enlarged, and complexity of operation and measurement cost are greatly reduced. Furthermore, research on brain health and brain disease mechanisms of different populations is expected to be established, and development of neuroscience and clinical medicine is promoted.

Description

technical field [0001] The invention relates to the fields of magnetic resonance imaging and physiological parameter measurement, and more specifically, to a method for dynamically measuring cerebral oxygen metabolism rate. Background technique [0002] The brain accounts for about 2% of the total body weight, but consumes 20% of the total energy consumed by the body. The energy requirements of the brain are almost entirely dependent on aerobic metabolism. Therefore, Cerebral Metabolic Rate of Oxygen (CMRO 2 ) – the rate at which the brain consumes oxygen, considered a key indicator of brain tissue vitality and brain function. Many Conditions and CMRO 2 associated with changes in diseases such as Huntington's disease, Alzheimer's disease, and stroke. In addition, CMRO 2 Quantitative measurements of β help to understand normal brain physiology at rest, in brain activity, and during physiological challenges. Therefore, the development of safe and non-invasive CMRO 2 Dyn...

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Problems solved by technology

[0006] In order to solve the problem that additional gas is required to measure cerebral oxygen metabolism rate by calibrating the BOLD method, the present invention proposes a method for dynamically measuring cerebral oxygen metabolism rate without additional use of gas, which combines Arterial SpinLabeling (ASL) technology with Multiple asymmetrical spin echo-based echo planar imaging (MultiechoAsymmetric Spin Echo, MASE) techniques are combined to simultaneously obtain cerebral blood flow (Cerebral Blood Flow, CBF) and cerebral oxygen uptake fraction (Oxygen Extraction Fraction, OEF) change information, and then by Fick's law (δCMRO 2 =(1+δCBF)·(1+δOEF)-1) Finally, the cerebral oxygen metabolism rate CMRO is realized 2 Measurement of dynamic changes

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