Method for dynamically measuring cerebral oxygen metabolism rate

A technology for dynamic measurement and metabolic rate, applied in measurement devices, measurement of magnetic variables, magnetic resonance measurement, etc., can solve problems such as the need for additional use of gas, improve comfort, reduce costs, and solve complexity and crowd limitations. Effect

Active Publication Date: 2020-05-05
XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI
View PDF17 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the problem that additional gas is required to measure cerebral oxygen metabolism rate by calibrating the BOLD method, the present invention proposes a method for dynamically measuring cerebral oxygen metabolism rate without additional use of gas, which combines Arterial SpinLabeling (ASL) technology with Multiple asymmetrical spin echo-based echo planar

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for dynamically measuring cerebral oxygen metabolism rate
  • Method for dynamically measuring cerebral oxygen metabolism rate
  • Method for dynamically measuring cerebral oxygen metabolism rate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0022] The principle and spirit of the present invention will be described below with reference to several exemplary embodiments. It should be understood that these embodiments are given only to enable those skilled in the art to better understand and implement the present invention, but not to limit the scope of the present invention in any way.

[0023]The present invention provides a perfusion imaging-based multiple asymmetric spin echo-echo planar imaging technology (Perfusion Multiecho Asymmetric Spin Echo, PMASE), which combines the advantages of ASL technology and MASE technology in time resolution, It is used for the research of functional magnetic resonance imaging (functional Magnetic Resonance Imaging, fMRI), and can also perform multi-layer acquisition under the condition that the temporal resolution remains unchanged.

[0024] A method for dynamically measuring cerebral oxygen metabolism rate according to the present invention utilizes the combination of arterial ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a method for dynamically measuring cerebral oxygen metabolism rate. According to the method, a perfusion multiecho asymmetric spin echo technology are adopted, namely, a multiecho signal acquisition mode formed by alternately switching a layer selection inversion mark and a non-layer selection inversion mark is adopted, oxygen extraction fraction (OEF) and cerebral blood flow (CBF) weighted images are synchronously obtained in a mode of adding/subtracting layer selection signals and non-layer selection signals, and measurement of dynamic change of the cerebral metabolicrate of oxygen (CMO2) is finally realized by combining Fick's law. According to the invention, a series of problems caused by gas calibration required by calibrating a blood oxygen level dependent (BOLD) method are fundamentally solved, so that the comfort level of a subject is greatly improved, the applicable population is enlarged, and complexity of operation and measurement cost are greatly reduced. Furthermore, research on brain health and brain disease mechanisms of different populations is expected to be established, and development of neuroscience and clinical medicine is promoted.

Description

technical field [0001] The invention relates to the fields of magnetic resonance imaging and physiological parameter measurement, and more specifically, to a method for dynamically measuring cerebral oxygen metabolism rate. Background technique [0002] The brain accounts for about 2% of the total body weight, but consumes 20% of the total energy consumed by the body. The energy requirements of the brain are almost entirely dependent on aerobic metabolism. Therefore, Cerebral Metabolic Rate of Oxygen (CMRO 2 ) – the rate at which the brain consumes oxygen, considered a key indicator of brain tissue vitality and brain function. Many Conditions and CMRO 2 associated with changes in diseases such as Huntington's disease, Alzheimer's disease, and stroke. In addition, CMRO 2 Quantitative measurements of β help to understand normal brain physiology at rest, in brain activity, and during physiological challenges. Therefore, the development of safe and non-invasive CMRO 2 Dyn...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61B5/055A61B5/145G01R33/48
CPCA61B5/055A61B5/14542G01R33/4806G01R33/4808Y02A90/30
Inventor 殷雅彦卢洁舒苏覃朗张苗李琼阁单艺
Owner XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap