Nano-composite and preparation method and application thereof

A nano-composite and polymer technology, which is applied in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., to achieve the effect of no cytotoxicity, significant effect, and improved targeting.

Active Publication Date: 2020-05-08
SHANDONG XINRUI BIOTECH CO LTD
View PDF3 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The inventors found that the commonly used antifungal drugs are antibacterial by inhibiting the synthesi...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Nano-composite and preparation method and application thereof
  • Nano-composite and preparation method and application thereof
  • Nano-composite and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Weigh 50mg of PEG(3000)-PTMC(6000) copolymer, 5mg of imatinib, add 1ml of dichloromethane, and ultrasonically dissolve the carrier material and drug fully. The solution was added to 5ml of 0.6% sodium cholate solution, and the ice-bath probe was sonicated with the ultrasonic power of 300W, the ultrasonic time of 3s, the ultrasonic interval of 3s, and the number of ultrasonic waves 10 times. After sonication, an emulsion was obtained, and the emulsion was rotary evaporated at 40° C. to remove dichloromethane to obtain the NPs-IM nanocomposite preparation.

[0055] Results: The average particle size of the prepared NPs-IM nanocomposite was 83.40±3.94nm.

Embodiment 2

[0057] Weigh 50mg of PEG(3000)-PTMC(6000) copolymer, 2mg of imatinib, add 1ml of dichloromethane, and ultrasonically dissolve the carrier material and drug fully. The solution was added to 5ml of 0.6% sodium cholate solution, and the ice-bath probe was sonicated with the ultrasonic power of 300W, the ultrasonic time of 3s, the ultrasonic interval of 3s, and the number of ultrasonic waves 10 times. After sonication, an emulsion was obtained, and the emulsion was rotary evaporated at 40° C. to remove dichloromethane to obtain the NPs-IM nanocomposite preparation.

[0058] Results: The average particle size of the prepared NPs-IM nanocomposite was 71.23±3.26nm.

Embodiment 3

[0060] Weigh 50mg of PEG(3000)-PTMC(6000) copolymer, 5mg of imatinib, add 1ml of dichloromethane, and ultrasonically dissolve the carrier material and drug fully. The solution was added to 5ml of 2% polyvinyl alcohol solution, and the ice-bath probe was sonicated, the ultrasonic power was 300W, the ultrasonic time was 3s, the ultrasonic interval was 3s, and the number of ultrasonic waves was 10 times. After sonication, an emulsion was obtained, and the emulsion was rotary evaporated at 40° C. to remove dichloromethane to obtain the NPs-IM nanocomposite preparation.

[0061] Results: The average particle size of the prepared PEG-PTMC nanocomposite was 84.44±3.83nm.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
The average particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention provides a nano-composite and a preparation method and application thereof. The raw materials of the nano-composite include Imatinib, pegylated polymer and mannose-modified chitosan oligosaccharide, wherein the outer layer of the nano-composite is wrapped by the mannose-modified chitosan oligosaccharide, Imatinib is wrapped and loaded by the pegylated polymer as a carrier inside thenano-composite, and the mass ratio of the pegylated polymer raw material to Imatinib is (8-50):1. The nano-composite can be taken in effectively by macrophages, M2-type differentiation of the macrophages can be blocked, M1-type differentiation of the macrophages is promoted, and the activity of the macrophages is improved, so that the survival time of immunosuppression-state mice which are infected with acute invasive fungi is prolonged, and the purpose of resistance to fungal infection is achieved.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a nanocomposite and its preparation method and application. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Macrophages (Macrophage), as the main member of innate immune cells, play an important role in various inflammatory reactions. Macrophages can be divided into classically activated macrophages (M1-type macrophages) and alternatively activated macrophages (M2-type macrophages), and the functions of the two are almost mutually antagonistic. M1 macrophages participate in the positive immune response by secreting pro-inflammatory cytokines, while M2 macrophages secrete ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/51A61K47/34A61K47/26A61K47/36A61K31/506A61P31/10
CPCA61K9/5123A61K9/5146A61K9/5161A61K31/506A61P31/10
Inventor 姜新义高琼琼张晶
Owner SHANDONG XINRUI BIOTECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap