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A kind of preparation method of fluorinated polyhexamethylene biguanide

The technology of fluorinated polyhexamethylene biguanide and polyhexamethylene biguanide hydrochloride is applied in the field of preparation of fluorinated polyhexamethylene biguanide, and can solve the problem of harming the health of the whole body, fluorine-resistant strains, and excessive fluoride intake. and other problems to achieve the effect of avoiding side effects, reducing side effects and low cost

Active Publication Date: 2020-12-08
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term use of fluoride ions with a high antibacterial concentration threshold will not only lead to the emergence of fluoride-resistant strains, but also may lead to excessive fluoride intake, which will endanger the health of the whole body

Method used

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  • A kind of preparation method of fluorinated polyhexamethylene biguanide
  • A kind of preparation method of fluorinated polyhexamethylene biguanide
  • A kind of preparation method of fluorinated polyhexamethylene biguanide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The polyhexamethylene biguanide hydrochloride powder (n=3) was dissolved in ultrapure water, and oscillated with a vortex oscillator until dissolved. Dissolve the silver fluoride powder in ultrapure water and vibrate with a vortex until dissolved. Add the high-concentration silver fluoride solution drop by drop into the polyhexamethylene biguanide hydrochloride solution, and a white flocculent precipitate will be formed after the addition, and continue to drop until the excess silver fluoride no longer produces new precipitates. Divide the obtained solution into 1.5mL centrifuge tubes, put them into a centrifuge, 12000rpm, 30min, carefully draw the supernatant into a new centrifuge tube, put it into the centrifuge again and repeat centrifugation until no precipitation occurs . Put the dialysis bag containing the sample into a glass beaker, add 2L of ultrapure water, place it on a magnetic stirrer for dialysis, and the ratio of the dialysis sample to the dialysate is 1:...

Embodiment 2

[0028] The polyhexamethylene biguanide hydrochloride powder (n=45) was dissolved in ultrapure water, oscillated with a vortex oscillator until dissolved and set aside. Dissolve the silver fluoride powder in ultrapure water and vibrate with a vortex until dissolved. Add the high-concentration silver fluoride solution drop by drop into the polyhexamethylene biguanide hydrochloride solution, and a white flocculent precipitate will be formed after the addition, and continue to drop until the excess silver fluoride no longer produces new precipitates. Divide the obtained solution into 1.5mL centrifuge tubes, put them into a centrifuge, 12000rpm, 30min, carefully draw the supernatant into a new centrifuge tube, put it into the centrifuge again and repeat centrifugation until no precipitation occurs . Put the dialysis bag containing the sample into a glass beaker, add 2L of ultrapure water, place it on a magnetic stirrer for dialysis, and the ratio of the dialysis sample to the dial...

Embodiment 3

[0030] The polyhexamethylene biguanide hydrochloride powder (n=4) was dissolved in ultrapure water, oscillated with a vortex oscillator until dissolved and set aside. Dissolve the silver fluoride powder in ultrapure water and vibrate with a vortex until dissolved. Add the high-concentration silver fluoride solution drop by drop into the polyhexamethylene biguanide hydrochloride solution, and a white flocculent precipitate will be formed after the addition, and continue to drop until the excess silver fluoride no longer produces new precipitates. Divide the obtained solution into 1.5mL centrifuge tubes, put them into a centrifuge, 12000rpm, 30min, carefully draw the supernatant into a new centrifuge tube, put it into the centrifuge again and repeat centrifugation until no precipitation occurs . Put the dialysis bag containing the sample into a glass beaker, add 2L of ultrapure water, place it on a magnetic stirrer for dialysis, and the ratio of the dialysis sample to the dialy...

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Abstract

The invention provides a method for preparing fluorinated polyhexamethylene biguanide. The method comprises the following steps: adding water into polyhexamethylene biguanide hydrochloride powder, dissolving, precipitating, removing the precipitate, dialyzing, centrifuging and drying to obtain the fluorinated polyhexamethylene biguanide. The method is mild in reaction condition, simple in preparation method and suitable for large-scale industrial production and application. The product fluorinated polyhexamethylene biguanide can give play to the synergistic effect of polyhexamethylene biguanide and sodium fluoride, effectively reduces the side effects when polyhexamethylene biguanide and sodium fluoride are independently used or used in a compatible manner, and can be applied to the fieldsof oral gargle, toothpaste, enamel remineralization liquids, fluorine foams and fluorine gels.

Description

technical field [0001] The invention belongs to the preparation technology of functional guanidine-based polymer functional materials, and relates to a preparation method of fluorinated polyhexamethylene biguanide. Background technique [0002] With the advancement and development of science and technology, people's understanding of microorganisms is getting deeper and deeper. In order to avoid the threat of pathogenic microorganisms to human health, cationic antibacterial agents have gradually appeared in people's daily life, and polyhexamethylene Biguanides are one of them. The antibacterial performance of polyhexamethylene biguanide mainly depends on the guanidine group it contains, which has high biological activity and safety. [0003] Fluoride is often found in various anti-caries products due to its unique antibacterial and remineralizing capabilities. Studies have found that the application of sodium fluoride can better inhibit the occurrence of demineralization ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G73/00A61K31/785A61K8/84A61P31/04A61P31/02A61Q11/00
CPCA61K8/84A61K31/785A61Q11/00A61P31/02A61P31/04C08G73/00
Inventor 李晓东陈亚栋罗巧洁段铸辉
Owner ZHEJIANG UNIV
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