The invention discloses a COVID19
antigen detection card as well as a preparation method and application thereof, and belongs to the field of nano materials and nano
medicine, an adopted
rare earth nano probe is
erbium fluoride sodium coated
sodium yttrium fluoride with a core-shell structure, the particle size is 20nm-30nm, the composition of the
rare earth nano probe is NaErF4@NaYF4, and NaErF4 is a full
erbium doped core structure, NaYF4 is a shell layer, and @ represents that the NaYF4 is coated on the surface of the NaErF4. The nano-probe is a
rare earth fluoride nano-material and has the advantages of low background, long
luminescence life, strong
fluorescence signal, high
signal-to-
noise ratio and the like, the probe is connected with a new crown
monoclonal antibody through a
covalent bond for marking, a marking product is stable, and the COVID19
antigen detection card has the characteristics of high sensitivity, high accuracy, rapid and simple detection and the like, and can be used for screening and detection of early-stage COVID19 suspected patient
throat swabs, nasal swabs, nasopharyngeal swabs and
saliva samples, so that clinical definite diagnosis can be quickly and specifically assisted.