In-situ sampling ionization spray kit

Abstract

The invention discloses an in-situ sampling ionization spray kit, which comprises a conductive sampling handle upper cover and a kit lower base with a capillary tube-sample storage tank structure, wherein the conductive sampling handle upper cover is used for collecting a sample and providing high-voltage electric connection during sample analysis; the kit lower base with the capillary tube-samplestorage tank structure is detachably clamped and fixed with the conductive sampling handle upper cover, and the sample storage tank is used for containing a sample and an eluting extraction solvent on the conductive sampling handle upper cover so as to enable a target analyte in the sample to enter the eluting extraction solvent to form an analysis solution; the conductive sampling handle upper cover is connected with high-voltage electricity, so that the analysis solution is enabled to enter the capillary tube from one end of the capillary tube in an electrified manner and be sprayed from the other end of the capillary tube to form spray. The in-situ sampling ionization spray kit provided by the invention realizes complete integration of sampling, separation and ionization spray, and hasthe advantages of high reliability, simple structure and strong applicability.

Description

technical field [0001] The invention relates to the technical field of mass spectrometer analysis, in particular to an in-situ sampling ionization spray kit. Background technique [0002] With the rapid increase in the demand for mass spectrometers in different scenarios such as clinical medicine, public safety, food hygiene, and environmental pollution, as well as the vigorous rise of mass spectrometry miniaturization and de-specialization, the development of fast, convenient, and low-professional sample pretreatment The program has become a hot spot in the field of development. At present, the most popular treatment scheme integrates sampling, separation, purification, ionization and other steps on a simple device, in which the traditional separation technology device is miniaturized based on micro-nano processing technology and a portable kit is integrated based on in-situ sampling and ionization technology are two important directions. [0003] Commercialized mass spec...

AI Technical Summary

Problems solved by technology

However, the core structure of the extraction nanoliter spray kit is a spray needle made of fine glass, which is difficult to manufacture, fill liquid, assemble porous fiber materials, etc., and the tip of the glass spray needle is fragile, which has a certain degree of danger. Another example is the microtube paper spray technology kit, which uses chromatographic paper to separate samples, and then combines capillary to generate electrospray, which shows outstanding analytical performance in the analysis of small molecule drugs in biological fluids, but based on paper-based chromatography The big problem encountered by the separated microtube spray technology is that the paper base has too strong adsorption capacity for polar targets and the mass spectrometry response is weak, so it is not suitable for the analysis of more polar targets.

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