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Application of pyrazine quinazoline triketone alkaloid compound in preparation of marine fouling organism control agent

A technology of pyrazinquinazoline trione and biological control agent, which is applied in the field of natural products and achieves the effects of good social benefits, inhibition of marine organism adhesion, and great potential for popularization and application.

Active Publication Date: 2020-06-05
SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] The structure of this pyrazine quinazolintrione alkaloid compound has been reported (Li GY, Yang T, LuoYG, et al. 2009. Brevianamide J, a new indole alkaloid dimer from fungus Aspergillus versicolor. Organic Letters, 11( 16): 3714-3717), but in the field of marine fouling biological control, there is no relevant report disclosing its anti-marine fouling biofouling effect and using it in the field of fouling biological control

Method used

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  • Application of pyrazine quinazoline triketone alkaloid compound in preparation of marine fouling organism control agent
  • Application of pyrazine quinazoline triketone alkaloid compound in preparation of marine fouling organism control agent
  • Application of pyrazine quinazoline triketone alkaloid compound in preparation of marine fouling organism control agent

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Experimental program
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Embodiment 1

[0020] Experimental group: quantitative pyrazine quinazoline trione alkaloid compound ((S)-4-benzyl-2H-pyrazine[2,1-b]quinazoline-1,3,6(4H)- Triketone) was dissolved in methanol, and the solution concentration was 282.6 μg / mL, and 1 mL of the solution was added to a petri dish with a diameter of 6 cm, and the bottom of the petri dish was uniformly covered. After the solvent is completely volatilized, the content of the pyrazine-quinazolintrione alkaloid compound coated on the bottom of the petri dish is 10 μg / cm 2 . Add 13 mL of filter-sterilized seawater.

[0021] Control group: Add 1mL of methanol to make it evenly distributed on the bottom of the culture dish, and then add 13mL of filtered and sterilized seawater after the volatilization is complete.

[0022] Blank group: add 13mL filtered and sterilized seawater.

[0023] Four parallel samples were set up in each of the experimental group, the blank group and the control group, and about 30 netted barnacle Venus larvae ...

Embodiment 2

[0028] Experimental group: pyrazine quinazoline trione alkaloid compound ((S)-4-benzyl-2H-pyrazine[2,1-b]quinazoline-1,3,6(4H)-trione ) was dissolved with solvent methanol to prepare a solution with a concentration of 28.26 μg / mL. Add 1 mL of the solution to a petri dish with a diameter of 6 cm and make it evenly cover the bottom of the petri dish. After the solvent is completely evaporated, the content of the compound coated on the bottom of the culture dish is 1.0 μg / cm 2 . Add 13 mL of filter-sterilized seawater.

[0029] Control group: add 1mL of methanol to make the solution evenly distributed on the bottom of the culture dish, wait for the solvent to evaporate completely, then add 13mL of filtered and sterilized seawater.

[0030] Blank group: add 13mL filtered and sterilized seawater.

[0031] Four parallel samples were set up in the experimental group, the blank group and the control group, and about 30 larvae were added to each. Cultivate in a dark environment in...

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Abstract

The invention discloses an application of a pyrazine quinazoline triketone alkaloid compound in preparation of a marine fouling organism control agent. The structural formula of the pyrazine quinazoline triketone alkaloid compound is shown as a formula (I). When the pyrazine quinazoline triketone alkaloid compound disclosed by the invention is coated on the surface of a solid at a low dosage, thepyrazine quinazoline triketone alkaloid compound has an obvious effect of inhibiting marine organism adhesion, so that the pyrazine quinazoline triketone alkaloid compound can be used for preparing the marine fouling organism control agent. The compound is a naturally existing organic compound; the water body environment cannot be polluted; the enrichment of the water body in organisms cannot be caused by food chain transmission; the marine antifouling agent is environment-friendly and high in safety, does not contain heavy metal elements such as copper and tin while effectively inhibiting marine organism attachment, has good social benefits from the perspective of environmental protection, has great popularization and application potential, and has good application prospects in marine fouling organism prevention and removal.

Description

Technical field: [0001] The invention belongs to the field of natural products, and in particular relates to the application of a pyrazine quinazolinetrione alkaloid compound in the preparation of marine fouling biological control agents. Background technique: [0002] Marine fouling organisms refer to all kinds of organisms that fix or inhabit the underwater parts of ships and marine facilities. The hazards caused by them are mainly increased resistance, reduced speed, increased fuel consumption and CO 2 Discharge; block the seawater pipeline system, change the metal corrosion process, cause localized corrosion or perforation corrosion; increase the dynamic load effect, cause drift, imbalance or even overturn of the facility; compete with breeding objects (such as shellfish) for attachment base and bait, hinder Its growth and development will reduce the quality of the product. [0003] Antifouling coatings are one of the most widely used technical methods in marine fouling...

Claims

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Application Information

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IPC IPC(8): C09D5/14
CPCC09D5/14
Inventor 曹文浩严涛佘志刚蔡润林林明晴
Owner SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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