A kind of gel, its complete set of raw materials and application

A gel, complete set of technology, applied in the direction of prosthesis, medical science, etc., can solve the problems of slow gel formation, unable to maintain a stable state, excessive swelling, etc., to reduce pain, reduce costs, and simple operation.

Active Publication Date: 2021-06-15
JIANGSU DISSUETECH MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, in subsequent further research, the applicant found that the hydrogel of CN201180005494.7 not only gels slowly, but also shrinks instead of swelling
However, although the hydrogels of CN201810203162.3, CN201910633258.8, CN20191032646.7, and CN201810806833.5 swell rapidly after gelling, on the one hand, their swelling tends to be excessive; Shrinkage, unable to maintain steady state

Method used

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  • A kind of gel, its complete set of raw materials and application
  • A kind of gel, its complete set of raw materials and application
  • A kind of gel, its complete set of raw materials and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The raw material of the gel set in this example is composed of the first component and the second component, the first component is aldehyde-modified polysaccharide, and the second component is composed of hydrazide-based small molecule and hydrazide-modified polysaccharide , the mass ratio of hydrazide-based small molecule to hydrazide-modified polysaccharide is 1:100-100:1; the ring-opening rate of aldehyde-modified polysaccharide is 10-70%, and the grafting rate of hydrazide-modified polysaccharide 10-80%. Note: During specific preparation, the ring-opening rate / grafting rate can be controlled by controlling the feed ratio and reaction time.

[0050] The first component is prepared by the following method:

[0051] The polysaccharide used in the first component is dissolved in purified water to form a polysaccharide solution; the oxidizing agent is added to the polysaccharide solution and reacted in the dark; after the reaction is completed, the product is purified ...

Embodiment 2

[0066] The gel of this embodiment is obtained by preparing the raw materials of the gel set in Example 1 through the following steps:

[0067] S1. Dissolving the first component in physiological saline or buffer to form a first solution, and dissolving the second component in physiological saline or buffer to form a second solution;

[0068] S2. Blending the first solution and the second solution; in the mixed solution of the first solution and the second solution, the molar ratio of the aldehyde group to the hydrazide group is 1:10 to 10:1;

[0069] S3. The mixed solution solidifies into a gel as time goes by, and the finished gel is obtained.

[0070] Specifically, the mass concentration of the first component in the first solution is 0.1-20%; the mass concentration of the second component in the second solution is 0.1-10%.

[0071] The buffer is selected from acetate buffer, phosphate buffer, and borate buffer; the pH range of the buffer is 2 to 10; the first solution and ...

Embodiment 3

[0076] In this embodiment, a swelling test is performed on the gel to be tested.

[0077] The test samples are: Example 1 gel of Example 2, comparative gel 1, and comparative gel 2.

[0078] Compared with the example 1 gel of Example 2, the second component of the comparison gel 1 is only the hydrazide group small molecule of the example 1 gel, and all the other parameters are the same; the second component of the comparison gel 2 is only The hydrazide-modified polysaccharide of Example 1 gel, all the other parameters are the same.

[0079] The detection method is: after the hydrogel is formed, the initial hydrogel weight is measured as W 0 , then put the gel into 0.9% NaCl, under the condition of 37 ℃, take out the gel at different time points, blot the surface moisture, measure its weight as W i , according to the following formula to calculate its swelling rate.

[0080] Swelling rate = (W i -W 0 ) / W 0 ×100%

[0081] The result is as figure 1 shown. This result sho...

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Abstract

The invention relates to a gel, a complete set of raw materials and applications thereof. The gel is obtained by in-situ cross-linking after blending the first solution and the second solution. The first component contained in the first solution is an aldehyde-modified polysaccharide, and the second component contained in the second solution is composed of a hydrazide group. Molecule, hydrazide-modified polysaccharide composition. The kit consists of a first component and a second component. The gel of the present invention is suitable for tissue engineering applications such as vitreous body replacement gel, ocular surface sealant, and fundus sealant.

Description

technical field [0001] The invention relates to a gel. The complete set of raw materials and application of the gel belong to the field of tissue engineering materials. Background technique [0002] As far as the applicant knows, hydrogel, as a tissue engineering material, is widely used in medicine, involving anti-adhesion materials, hemostatic materials, filling scaffolds for bone defect repair, tissue adhesives, slow-release drug carriers, antibacterial and anti-infection dressings, etc. Many applications. [0003] The invention patent of patent number CN201180005494.7 and authorized announcement number CN102762647B discloses a hydrogel polymer comprising oxidized hyaluronic acid and dihydrazide, and the dihydrazide crosslinks the oxidized hyaluronic acid. [0004] Application number CN201810203162.3, application publication number CN108478867A patent application for invention, discloses injectable polymer hydrogel raw materials, including: component one obtained by modi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/52A61L27/20C08L5/08C08L5/04C08L1/04C08J3/075
CPCA61L27/20A61L27/52C08J3/075C08J2301/04C08J2305/04C08J2305/08C08J2401/04C08J2405/04C08J2405/08C08L5/08C08L5/04C08L1/04
Inventor 吴亮亮曹彬万文倩朱健
Owner JIANGSU DISSUETECH MEDICAL TECH CO LTD
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