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Soft-back microneedle and manufacturing method thereof

A production method and microneedle technology, which is applied in the direction of microneedles, needles, and other medical devices, can solve the problems that povidone microneedles are difficult to insert into the skin, cannot be curved, matched, and the hardness of the microneedle substrate is large, achieving Does not cause skin allergies, good skin feeling effect

Pending Publication Date: 2020-06-19
尹忠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to provide a soft-backed microneedle that can be made into a larger area and used to fit the curvature of the skin, to solve the problem of high hardness and polydimensional problems of the microneedle substrate made of metal and inorganic silicon materials in the prior art. The technical problems that ketone microneedles are difficult to insert into the skin and cannot match the curvature of the human body surface

Method used

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  • Soft-back microneedle and manufacturing method thereof
  • Soft-back microneedle and manufacturing method thereof
  • Soft-back microneedle and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The production process of the soft back microneedle in this embodiment is as follows: image 3 As shown, the manufacturing method of the soft-backed microneedle in this embodiment includes the following steps: (1) heating and deforming the thermoplastic raw material for preparing the microneedle to a fluid state; (2) as Figure 6 As shown, the bottom plate 8, the soft liner 7, the isolation layer 6, the template 5 and the upper plate 4 for preparing the microneedles are placed in sequence from bottom to top, and the upper plate 4, the template 5, the isolation layer 6, the soft liner 7 and base plate 8 are all heat-resistant materials, and the isolation layer 6 is an air-permeable and liquid-tight material. The template 5 is provided with a microporous area 51 corresponding to the needles of the microneedles. There are several microporous areas in one microporous area. A microhole, the microhole is a through hole provided on the template, and the position corresponding ...

Embodiment 2

[0043] The production process of the soft back microneedle in this embodiment is as follows: Figure 4 As shown, the manufacturing method of the soft-backed microneedle in this embodiment includes the following steps: (1) process the thermoplastic raw material for preparing the microneedle into powder, and weigh the powder raw material equal to the weight of a single microneedle; (2) as Figure 6 as shown in Figure 6 As shown, the bottom plate 8, the soft liner 7, the isolation layer 6, the template 5 and the upper plate 4 for preparing the microneedles are placed in sequence from bottom to top, and the upper plate 4, the template 5, the isolation layer 6, the soft liner 7 and base plate 8 are all heat-resistant materials, and the isolation layer 6 is an air-permeable and liquid-tight material. The template 5 is provided with a microporous area 51 corresponding to the needles of the microneedles. There are several microporous areas in one microporous area. A microhole, the m...

Embodiment 3

[0045] The production process of the soft back microneedle in this embodiment is as follows: Figure 5 As shown, the manufacturing method of the soft-backed microneedle in this embodiment includes the following steps: (1) processing the thermoplastic raw material for preparing the microneedle into a solid with the same weight as a single microneedle; (2) as Figure 6 as shown in Figure 6 As shown, the bottom plate 8, the soft liner 7, the isolation layer 6, the template 5 and the upper plate 4 for preparing the microneedles are placed in sequence from bottom to top, and the upper plate 4, the template 5, the isolation layer 6, the soft liner 7 and base plate 8 are all heat-resistant materials, and the isolation layer 6 is an air-permeable and liquid-tight material. The template 5 is provided with a microporous area 51 corresponding to the needles of the microneedles. There are several microporous areas in one microporous area. A microhole, the microhole is a through hole pro...

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Abstract

The invention discloses a soft-back microneedle and a manufacturing method thereof, and belongs to the technical field of medical equipment. The soft-back microneedle comprises a base plate and needle-shaped objects fixed at the bottom of the base plate, the base plate and the needle-shaped objects are integrally cast and formed together, the base plate and the needle-shaped objects are made of thermoplastic materials, the base plate is a bendable soft flexible plate, and each needle-shaped object is of a big-top small-bottom structure. The soft-back microneedle is made of a thermoplastic material, and the thermoplastic material has the following advantages that 1, the thermoplastic material is safe and does not cause skin allergy; 2, after the microneedle made of the thermoplastic material is inserted into skin to make contact with body fluid, the skin feeling is better; and 3, the thermoplastic material is insoluble or slightly soluble in water or can still keep enough adhesiveness after meeting water, and can be conveniently pulled out after drug delivery is finished instead of being dissolved in the skin. Moreover, the thermoplastic material can be made into a deformable flexible material, the manufactured base plate is the bendable soft flexible plate, and then an auxiliary layer which is also soft is adhered to the base plate, so that the microneedle can meet the use requirements of a large number of large-area and large-curvature human body parts.

Description

technical field [0001] The invention relates to a soft back microneedle and a manufacturing method thereof, belonging to the technical field of medical equipment. Background technique [0002] Oral administration of protein and polypeptide drugs will be degraded and invalid after passing through the stomach, so they can only be administered by injection. Injection is actually a way for drugs to pass through the biological barrier of the skin with the help of needles, but it only increases the pain, especially for long-term frequent injections. The non-injection administration of such drugs is a long-cherished wish. For example, since 1921, non-injection administration of insulin has been studied to avoid long-term frequent injections. There have been many non-injection drug delivery methods. Among them, there are two most famous cases. The first is Pfizer’s inhalant, which took 14 years and cost 2.8 billion US dollars. Withdrawal from the market; the second is that Glaxo's...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0053A61M37/00
Inventor 尹忠
Owner 尹忠
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