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Establishment device and evaluation method for silicosis animal model

A technology of animal model and generating device, which is applied in the field of silicosis research device, can solve problems such as the complicated pathogenesis of silicosis, and achieve the effect of reliable evaluation standards, easy-to-obtain materials and low cost

Active Publication Date: 2020-06-30
山东省职业卫生与职业病防治研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The pathogenesis of silicosis is very complex and has not yet been fully elucidated

Method used

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  • Establishment device and evaluation method for silicosis animal model
  • Establishment device and evaluation method for silicosis animal model
  • Establishment device and evaluation method for silicosis animal model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A device for establishing animal models of silicosis, mainly composed of three parts, the upper part is a silica dust aerosol generating device 1, the middle part is an animal dust staining cabinet 2, and the lower part is a waste gas treatment device 3.

[0042] Silica dust aerosol generating device 1 is a silica dust generating device, which is composed of a silica dust stirring device 5 with a stainless steel scraper 7, a stainless steel drain plate 6 with a hole in the bottom, and a cylindrical tank 4. The test object is free silica Composed of quartz sand with a content greater than 99%, the particle size is 8000 mesh, and the dust concentration is 1000mg / m 3 According to the concentration of the sampling port, the rotating speed of the scraper 7 is adjusted to obtain the silica dust aerosol at this concentration level; the hole on the stainless steel plate is 2 mm in diameter, and the position is on the side of the scraper 7; the circular tank body 4 is made of ple...

Embodiment 2

[0046] The method for establishing and evaluating an animal model of silicosis through a device for establishing an animal model of silicosis includes two parts: the establishment and evaluation of an animal model at the inflammatory stage of silicosis, and the establishment and evaluation of an animal model at the fibrosis stage of silicosis; both of which include the following: Experimental animals were put into animal fixed bottles respectively, and the free silica content was greater than 99%, and the concentration was 1000mg / m 3 Silica dust is contaminated through natural inhalation.

[0047] The model building evaluation indicators are as follows.

[0048] 1. Selection of evaluation indicators.

[0049] Hydroxyproline (HYP) content in lung tissue: HYP content in lung tissue was detected on the 3rd, 14th, 28th, and 60th day. With the prolongation of dust exposure time, the content showed an upward trend, and the highest content was at 60 days.

[0050] Transforming grow...

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Abstract

The invention discloses an establishment device and evaluation method for a silicosis animal model. The device is divided into three parts communicating from top to bottom, the upper part is a silicious dust aerosol generation device, the middle part is an animal dust contamination cabinet, and the lower part is a waste gas treatment device; the silicious dust aerosol generation device is used forsilicious dust generation and comprises a tank, a silicious dust stirring device arranged in the tank and a leaking plate arranged at the bottom of the tank; an upper layer and a lower layer are arranged in the dust contamination cabinet, the upper layer is a uniform silicious dust aerosol mixing device, and the lower layer is a rat fixing and dust suction device; an opening is formed in the waste gas treatment device and connected with a filtering dust removal bag; and each connection part is subjected to seal treatment. The invention further provides the method for establishing and evaluating the silicosis animal model by using the device. The establishment device and evaluation method can conveniently and simply establish the effective silicosis animal model, provide a good work basisfor research on the silicosis pathogenesis and treatment, and also provide an objective, direct and reliable standard for the silicosis animal model.

Description

technical field [0001] The invention relates to a device and method for silicosis research, in particular to a device for establishing an animal model of silicosis and an evaluation method thereof. Background technique [0002] Silicosis (Silicosis) is an occupational disease caused by inhalation of quartz dust in the lungs, with inflammation and scarring in the form of pulmonary nodular lesions of the upper lobe. A type of disease. The lung organ is one of the main internal organs of the human body. The inhaled air undergoes gas exchange in the alveoli, expelling carbon dioxide, oxygenating the blood, and sending it back to the heart. Oxygenated blood is transported to various parts of the body by the beating of the heart. People suffering from pneumoconiosis, because the function of exchanging gases is blocked, the oxygen in the blood is insufficient and the carbon dioxide is too much. If this phenomenon persists for a long time, it will lead to right ventricular hypert...

Claims

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Application Information

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IPC IPC(8): A01K1/03B01D46/02G01N1/30G01N33/68
CPCA01K1/03B01D46/02G01N1/30G01N33/68G01N33/6872G01N2333/495
Inventor 张海东杨治峰张津玮
Owner 山东省职业卫生与职业病防治研究院
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