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Novel use of a pharmaceutical composition comprising n-valeric acid, indole propionic acid and sodium n-butyrate

A technology of indole propionic acid and sodium n-butyrate, applied in the field of medicine, can solve the problems of easy drug resistance, inability to mobilize the human body, and large toxic and side effects, achieve good safety, improve tumor microenvironment and body health, and reduce toxicity. Effects with low side effects

Active Publication Date: 2021-06-15
INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to overcome the problems caused by exogenous small-molecule anti-hepatic cancer drugs, such as easy drug resistance, high toxicity and side effects, and inability to mobilize the human body to actively inhibit tumor progression, the present invention provides Novel use of the pharmaceutical composition of intestinal flora metabolites, that is, the use of the pharmaceutical composition in the preparation of pharmaceutical preparations for the prevention and / or treatment of liver cancer

Method used

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  • Novel use of a pharmaceutical composition comprising n-valeric acid, indole propionic acid and sodium n-butyrate
  • Novel use of a pharmaceutical composition comprising n-valeric acid, indole propionic acid and sodium n-butyrate
  • Novel use of a pharmaceutical composition comprising n-valeric acid, indole propionic acid and sodium n-butyrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Example 1: In vivo anti-hepatoma effect investigation experiment.

[0071] 1. Model establishment:

[0072] Culture HepG2 cells according to 2×10 per mouse 8 Cells were inoculated at the axillary venous plexus of Balb / c nude mice to construct a human liver cancer tumor-bearing mouse model.

[0073] 2. Administration method:

[0074] When the tumor grows to a volume of 100mm 3 start dosing. Dosing once a day at 2 o'clock in the afternoon, continuous administration for 27 days, the specific administration situation is as follows:

[0075] Treatment group: the solution (concentration of n-valeric acid, indole propionic acid and sodium n-butyrate is 15, 7.5 and 7.5 successively by dissolving the pharmaceutical composition comprising n-valeric acid, indole propionic acid and sodium n-butyrate in purified water mg / mL), intragastric administration, 200 μL / piece / time;

[0076] Control group: purified water, intragastric administration, 200 μL / rat / time.

[0077] 3. Observ...

Embodiment 2

[0088] Example 2: In vitro anti-hepatoma effect investigation experiment.

[0089] 1. Preparation of storage solution:

[0090] Dissolve an appropriate amount of n-valeric acid in double-distilled water to obtain a stock solution of n-valeric acid with a final concentration of 0.1M, and store it at 4°C;

[0091] Dissolve an appropriate amount of indole propionic acid in absolute ethanol to obtain a stock solution of indole propionic acid with a final concentration of 0.3M, and store it at 4°C;

[0092] An appropriate amount of sodium n-butyrate was dissolved in double-distilled water to obtain a stock solution of sodium n-butyrate with a final concentration of 0.1M, which was stored at 4°C.

[0093] 2. Cell culture:

[0094] In DMEM medium supplemented with 10% fetal bovine serum, 100 U / mL penicillin and 0.1 mg / mL streptomycin, the HepG2 human liver cancer cell line was incubated at 37°C, 5% CO 2 cultivated in the environment. In the CCK-8 experiment, the cells were seeded...

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Abstract

The invention belongs to the field of medicine and relates to a new application of a pharmaceutical composition comprising n-valeric acid, indole propionic acid and sodium n-butyrate. Specifically, the pharmaceutical composition comprising n-valeric acid, indole propionic acid and sodium n-butyrate can be used to prepare a drug for preventing and / or treating liver cancer. Each component in the composition is a common small molecule compound, the synthesis process is mature and simple, and it is easy to obtain. They are all metabolites of intestinal microorganisms in the body, with extremely low toxic and side effects and good safety. It can improve the tumor microenvironment and the health status of the body through the interaction between microorganisms and the host, and mobilize the body's spontaneous anti-hepatic cancer effect. In addition, the preparation method of the composition is simple, the administration method is convenient, and the patients are easy to accept.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new application of a pharmaceutical composition comprising n-valeric acid, indole propionic acid and sodium n-butyrate, that is, its application in the preparation of medicines for preventing and / or treating liver cancer. Background technique [0002] Cancer is one of the three major diseases that threaten human health in the 21st century, among which liver cancer is the malignant tumor with the second highest fatality rate in the world (see Global Burden of Disease Cancer Collaboration, Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990to 2016: A Systematic Analysis for the Global Burden of Disease Study [J], JAMA Oncology, 2018, 4(11):1553-1568) , its morbidity and mortality are both high and on the rise, with about 700,000 new cases worldwide each year. my country is ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/19A61K31/405A61P35/00
CPCA61K31/19A61K31/405A61P35/00A61K2300/00
Inventor 崔明张书琴肖惠文李源董佳丽
Owner INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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