An injectable calcium-phosphorus ceramic for promoting tendon-bone healing, its preparation method and application

A technology of calcium phosphorus ceramics and tricalcium phosphate ceramics, which is applied in the fields of pharmaceutical formulations, prostheses, drug delivery, etc., to promote early tendon-bone healing, enhance the effect of promoting tendon-bone healing, and alleviate the effect of low pull-off strength

Active Publication Date: 2022-02-01
SICHUAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the above treatment techniques have certain limitations

Method used

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  • An injectable calcium-phosphorus ceramic for promoting tendon-bone healing, its preparation method and application
  • An injectable calcium-phosphorus ceramic for promoting tendon-bone healing, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1) Take medical sterile collagen and prepare 10ml of 1.0% aqueous solution.

[0033] 2) Preparation of hydroxyapatite ceramic particles with a particle size of 10-100 μm: Ca(NO 3 ) 2 4H 2 O and (NH 4 ) 2 HPO 4 The powder is used as a raw material, and the hydroxyapatite ceramic particles are prepared by a hydrothermal synthesis method. The obtained suspension is configured into a slurry with a concentration of 80-100mg / ml and good particle dispersion, which is transported to a spray dryer by a peristaltic pump for spray drying treatment, and then the spray-dried powder is treated with a standard sampling sieve Sieving is carried out to obtain low-crystallinity, nearly spherical hydroxyapatite ceramic particles with a particle size of 10-100 μm, and the obtained calcium-phosphorus ceramic particles are kept at 250° C. for 2 hours for dry heat sterilization.

[0034] 3) Take 10 g of hydroxyapatite ceramic particles with a particle size of 10-100 μm obtained in step ...

Embodiment 2

[0037] 1) Take an appropriate amount of collagen solution with a concentration of 5mg / ml, add a corresponding amount of methacrylic anhydride at 4°C, adjust the pH of the reaction solution to 8.0-9.0 with 5mol / L NaOH, and react for 8 hours.

[0038] 2) Collagen modified with methacrylic anhydride (the degree of modification is 10%-30%) is prepared into 20 ml of a solution with a mass fraction of 2% in PBS.

[0039] 3) Add the photoinitiator to the above solution, mix well and keep away from light. The solid content of the initiator is 0.079‰.

[0040]4) Preparation of hydroxyapatite ceramic particles with a particle size of 10-100 μm: Ca(NO 3 ) 2 4H 2 O and (NH 4 ) 2 HPO 4 The powder is used as a raw material, and the hydroxyapatite ceramic particles are prepared by a hydrothermal synthesis method. The obtained suspension is configured to a certain concentration to form a slurry with good particle dispersion, which is transported to a spray dryer by a peristaltic pump f...

Embodiment 3

[0044] 1) Take medical sterile collagen and prepare 10ml of 1.0% aqueous solution.

[0045] 2) Preparation of tricalcium phosphate ceramic particles with a particle size of 20-50 μm: Disperse tricalcium phosphate micropowder into 1.0% polyvinyl alcohol aqueous solution, transfer to a ball mill and mill for 24 hours to form a slurry with good particle dispersibility, pass through a peristaltic pump Transport it to a spray dryer for spray drying, collect the spray-dried powder, and then sieve the powder with a standard sieve to obtain low-crystallinity, nearly spherical tricalcium phosphate ceramic particles with a particle size of 20-50 μm. The obtained calcium-phosphorus ceramic particles were incubated at 250° C. for 2 hours for dry heat sterilization.

[0046] 3) Get 10 g of tricalcium phosphate ceramic particles with a particle size of 20-50 μm obtained in step 2), add them to the above-mentioned collagen solution and stir evenly to form a paste compound (the solid content ...

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Abstract

The invention discloses an injectable calcium-phosphorus ceramic for promoting tendon-bone healing, and relates to the field of biomedical materials; the material is composed of calcium-phosphorus ceramics and natural macromolecules or derivatives thereof; the natural macromolecules Its derivatives are collagen and collagen modified products. The invention also discloses the preparation method and application of the calcium phosphorus ceramic.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to an injectable calcium-phosphorus ceramic for promoting tendon-bone healing, a preparation method and application thereof. Background technique [0002] The Anterior Cruciate Ligament (ACL) is the main ligament support structure of the knee joint. Its main function is to limit the hyperextension of the knee joint and prevent excessive forward movement and rotation of the tibia, which is more likely to cause damage during emergency stops and sudden changes of direction. Anterior cruciate ligament injury is a common sports injury of the knee joint, and ACL injury leads to limited knee joint function. The annual incidence of anterior cruciate ligament injury in the United States is about 1 / 3000, with more than 200,000 cases per year, of which 100,000 to 150,000 cases require ACL reconstruction surgery to restore normal structure and function. [0003] Rotator cuff injury is one o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/42A61L27/50A61L27/56A61L27/58
CPCA61L27/425A61L27/50A61L27/56A61L27/58A61L2430/10A61L2430/02A61L2430/06A61L2400/06C08L89/00
Inventor 林海江青松王立人卢婷苏金磊胡洪蒋佳燕晓宇朱向东赵金忠张兴栋
Owner SICHUAN UNIV
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