Application of radix physochlainae extract in preparation of drugs for preventing and treating myopia

An extract and myopia technology, applied in the field of biomedicine, can solve problems such as the improvement effect of myopia that has not yet been seen, and achieve the effect of delaying the progress of myopia, high safety, and remarkable therapeutic effect

Inactive Publication Date: 2020-07-03
毕宏生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no research related to the effect of Huashan ginseng on the improvement of myopia

Method used

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  • Application of radix physochlainae extract in preparation of drugs for preventing and treating myopia
  • Application of radix physochlainae extract in preparation of drugs for preventing and treating myopia
  • Application of radix physochlainae extract in preparation of drugs for preventing and treating myopia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 Preparation of Huashan Ginseng Extract by Ultrasonic Extraction

[0040] The preparation method of Huashan ginseng extract comprises the following steps:

[0041] (1) extraction

[0042] Grind Huashan ginseng to make Huashan ginseng powder, weigh 2g of Huashan ginseng powder and put it into a conical flask, add 70% ethanol as an extractant according to the ratio of solid to liquid 1:25 (g / mL), at a temperature of 30°C, Ultrasonic (350W, 50Hz) treatment was performed for 30 minutes; vacuum filtration while hot, and the filtrates were combined to obtain an extract.

[0043] (2) concentrated

[0044] Concentrate the extract under reduced pressure until it has no alcohol smell, and set it aside.

Embodiment 2

[0045] Example 2 Preparation of Huashan ginseng extract by heating and reflux extraction

[0046] The preparation method of Huashan ginseng extract comprises the following steps:

[0047] (1) extraction

[0048] Grind Huashan ginseng to make Huashan ginseng powder, weigh 200g Huashan ginseng powder, put it into a 2L round bottom flask, add 70% ethanol solution until the sample can be completely soaked, and extract in a constant temperature (100°C) water bath for 3 hours , the obtained extract is filtered with gauze, and the filtrate is collected; the above operation is repeated once again; finally, the filtrate is combined to obtain the extract.

[0049] (2) concentrated

[0050] Concentrate the extract under reduced pressure until it has no alcohol smell, and set it aside.

Embodiment 3

[0051] Example 3 Preparation of Huashan Ginseng Extract by Decoction

[0052] The preparation method of Huashan ginseng extract comprises the following steps:

[0053] (1) extraction

[0054] Grind Huashan ginseng to make Huashan ginseng powder, weigh 200g Huashan ginseng, add water to extract twice, each time for 2 hours, collect the filtrate, concentrate under reduced pressure to a clear paste with a relative density of 1.25-1.35 (60°C), add ethanol For precipitation, adjust the amount of ethanol to 70%, let stand, and take the supernatant.

[0055] (2) concentrated

[0056] Concentrate the supernatant under reduced pressure until it has no alcohol smell, and set it aside.

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PUM

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Abstract

The invention provides application of a radix physochlainae extract in preparation of drugs for preventing and treating myopia. Effective compositions such as anisodamine, scopolamine and scopoletin in the radix physochlainae extract are obtained through tests, the purpose of preventing and treating myopia can be achieved, and the defect that clinical application cannot be achieved due to potential side effects caused by long-term single use of anticholinergic drugs can be effectively overcome. The radix physochlainae extract has a remarkable treatment effect on myopia, is high in safety, andis expected to be popularized and applied clinically. Experiments prove that the radix physochlainae extract can be used for improving myopia by regulating scleral fibrous layers and retinal pigment cells, influencing expression of matrix metalloproteinase 2, matrix metalloproteinase inhibitor 2 and the like, regulating spasm of ciliary muscles and the like. The invention also provides a composition. The composition comprises effective components of the radix physochlainae extract; and the composition provides a new way for preventing and treating myopia.

Description

technical field [0001] The invention relates to the application and related application of Huashan ginseng extract in the preparation of medicines for preventing and / or treating myopia, and belongs to the technical field of biomedicine. Background technique [0002] The prevalence of myopia among children and adolescents in our country continues to rise, and it is developing towards high incidence and younger age. The number of patients ranks first in the world, and the prevention and treatment of myopia is a worldwide problem. At present, the treatment of myopia includes surgical intervention, drug therapy, optical correction, etc. Surgical treatment is interventional therapy, suitable for low and medium myopia, and has certain damage; drug treatment includes mydriatics, miotics, vasodilators and antispasmodics, etc. , which is mainly used to prevent and treat pseudomyopia, has relatively high potential toxic and side effects, and has a relatively high risk to children and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61P27/10A61K31/37A61K31/46A61K125/00
CPCA61K9/0048A61K31/37A61K31/46A61K36/81A61P27/10
Inventor 毕宏生郭俊国吴建峰宋继科解孝锋赵海强
Owner 毕宏生
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