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Anti-aging slow-release soluble microneedle based on polylactic acid compound and preparation method of microneedle

A technology of polylactic acid microspheres and polylactic acid, which is applied in chemical instruments and methods, microneedles, medical instruments, etc., can solve the problems of short duration of effect and inability to maintain the effect for a long time.

Inactive Publication Date: 2020-07-07
上海缓释生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the current soluble microneedles have a short duration of effect and cannot maintain the effect for a long time.

Method used

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  • Anti-aging slow-release soluble microneedle based on polylactic acid compound and preparation method of microneedle
  • Anti-aging slow-release soluble microneedle based on polylactic acid compound and preparation method of microneedle
  • Anti-aging slow-release soluble microneedle based on polylactic acid compound and preparation method of microneedle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] This example provides a preparation method for anti-aging slow-release soluble microneedles based on polylactic acid compounds, such as figure 1 shown, including:

[0053] S11. adding the polylactic acid oily solution into an aqueous solution of polyvinyl alcohol and stirring to obtain a polylactic acid emulsion, and drying the emulsion to obtain polylactic acid microspheres;

[0054] S12. Mixing and treating the obtained polylactic acid microspheres with the first soluble polymer to obtain a soluble polymer needle tip solution containing polylactic acid;

[0055] S13. Mixing and treating the second soluble polymer with sterile water to obtain a soluble polymer base solution;

[0056] S14. Coating and filling the microneedle mold with the obtained needle tip solution, scraping off the excess needle tip solution and air bubbles in the microneedle mold to obtain a first microneedle mold;

[0057] S15. Coating the obtained soluble polymer base solution to the first micro...

Embodiment 2

[0112] The difference between the preparation method of anti-aging slow-release soluble microneedles based on polylactic acid compounds provided in this example and Example 1 is that:

[0113] This embodiment is described by specific proportioning:

[0114] S11. dissolving L-polylactic acid in methylene chloride at a mass ratio of 1:19 to make a solution;

[0115] S12. At 15°C, slowly add the L-polylactic acid solution into the aqueous solution containing 0.5% polyvinyl alcohol while stirring, stir at a high speed for a period of time, and the stirring speed is 1200r / min;

[0116] S13. heating to 40° C. to evaporate the solvent;

[0117] S14. After the solvent is evaporated, centrifuge, wash, and place in a vacuum environment with a vacuum degree of -0.06Mpa to dry for 24 hours at room temperature to obtain L-polylactic acid microspheres;

[0118] S15. dissolving the polylactic acid microspheres in sterile water at a mass ratio of 1:5 to obtain a polylactic acid solution;

...

Embodiment 3

[0132] The difference between the preparation method of anti-aging slow-release soluble microneedles based on polylactic acid compounds provided in this example and Example 1 is that:

[0133] This embodiment is described by specific proportioning:

[0134] S11. Polyglycolide is dissolved in methylene chloride at a mass ratio of 1:19 to form a solution;

[0135] S12. At 15°C, slowly add the polyglycolide solution into the aqueous solution containing 1% polyvinyl alcohol while stirring, stir at high speed for a period of time, and the stirring speed is 1000r / min;

[0136] S13. heating to 40° C. to evaporate the solvent;

[0137] S14. After the solvent is evaporated, centrifuge, wash, and place at room temperature in a vacuum environment with a vacuum degree of -0.06Mpa to dry for 24 hours to obtain polyglycolide microspheres;

[0138] S15. Dissolving the polyglycolide microspheres in sterile water at a mass ratio of 1:10 to obtain a polyglycolide solution;

[0139] S16. Weig...

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Abstract

The invention discloses a preparation method of an anti-aging slow-release soluble microneedle based on a polylactic acid compound. The preparation method comprises the following steps of S11, addinga polylactic acid oily solution into an aqueous solution of polyvinyl alcohol and stirring to obtain a polylactic acid emulsion, and drying the emulsion to obtain polylactic acid microspheres; S12, carrying out mixing and treating on the obtained polylactic acid microspheres with a first soluble polymer to obtain a soluble polymer needle tip solution containing polylactic acid; S13, carrying out mixing and treating on the second soluble polymer with sterile water to obtain a soluble polymer substrate solution; S14, coating and filling a micro-needle die with the obtained needle tip solution, scraping off redundant needle tip solution and air bubbles in the micro-needle die to obtain a first micro-needle die; S15, coating the first micro-needle die with the obtained soluble polymer substrate solution to obtain a second micro-needle die; and S16, processing the obtained second micro-needle die to obtain the anti-aging slow-release soluble microneedle.

Description

technical field [0001] The invention relates to the technical field of medical methods, in particular to anti-aging slow-release soluble microneedles based on polylactic acid compounds and a preparation method thereof. Background technique [0002] Facial aging is a complex process that involves changes in soft tissue and bone structure. Aging can cause fat in certain areas of the face to shrink, thereby destroying the entire smooth surface of the face and forming wrinkles. Therefore, facial wrinkles can be effectively removed by filling the cavities formed by facial lipoatrophy. Currently, injectable alternative fillers are mainly used to fill the cavity formed by facial lipoatrophy. Although injecting alternative fillers such as hyaluronic acid (HA) can immediately fill the cavity created by lipoatrophy, hyaluronic acid is absorbed by the body in the body and loses its filling effect. Therefore, the current soluble microneedles have the problem of short duration of effec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61L27/18A61L27/20A61L27/16A61L27/54A61L27/50B01J19/02B29C41/02
CPCA61M37/0015A61L27/18A61L27/20A61L27/16A61L27/54A61L27/50B01J19/02B29C41/02A61L2300/216A61L2300/412A61L2300/602A61M2037/0053A61M2037/0061C08L67/04C08L5/08C08L29/04
Inventor 林旭王媛媛
Owner 上海缓释生物科技有限公司
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