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Local medicine preparation with cinacalcet

A technology of cinacalcet and topical drug, applied in the directions of medical preparations, drug combinations, drug delivery, etc. containing active ingredients, can solve the problems of high incidence of hypocalcemia, irritation, etc., to achieve enhanced therapeutic effect, high Drug concentration, the effect of avoiding side effects

Active Publication Date: 2020-07-14
NANJING HAIWEI PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The cinacalcet preparations currently on the market are all oral preparations, but oral administration of cinacalcet has strong irritation to the gastrointestinal tract and a high incidence of hypocalcemia

Method used

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  • Local medicine preparation with cinacalcet
  • Local medicine preparation with cinacalcet
  • Local medicine preparation with cinacalcet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Weigh 1g of cinacalcet, 5g of isopropyl myristate, 89g of petrolatum and 5g of liquid paraffin according to the formula, melt the cinacalcet, petrolatum, isopropyl myristate and liquid paraffin at 55°C and stir to mix, Cool to room temperature to obtain the local pharmaceutical preparation containing cinacalcet.

Embodiment 2

[0022] Weigh 1g of cinacalcet, 10g of isopropyl myristate, 84g of vaseline and 5g of liquid paraffin according to the formula, and stir and mix cinacalcet, vaseline, isopropyl myristate and liquid paraffin at 55°C, Cool to room temperature to obtain the local pharmaceutical preparation containing cinacalcet.

Embodiment 3

[0024] Weigh 1g of cinacalcet, 15g of isopropyl myristate, 79g of vaseline and 5g of liquid paraffin according to the formula, and stir and mix cinacalcet, vaseline, isopropyl myristate and liquid paraffin at 55°C after melting, Cool to room temperature to obtain the local pharmaceutical preparation containing cinacalcet.

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PUM

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Abstract

The invention discloses a local medicine preparation with cinacalcet. The local medicine preparation comprises the following components: 1% of cinacalcet, 0-10% of a penetrant, 0-20% of a solvent and84-94% of a matrix. The local medicine preparation with the cinacalcet is prepared by dissolving the cinacalcet, the penetrant and the matrix into the solvent, heating the components to 55 DEG C, stirring and mixing the components, and cooling the mixture to the room temperature. By adopting a local drug delivery mode, gastrointestinal tract irritation caused by orally taken medicines can be avoided, a high medicine concentration can be maintained in local action tissue, the treatment effect can be improved, side reactions of a whole body can be avoided, and remarkable clinical advantages canbe achieved.

Description

technical field [0001] The present invention relates to a topical pharmaceutical formulation comprising cinacalcet. Background technique [0002] Chronic kidney disease (CKD) is one of the common chronic diseases in China, and secondary hyperparathyroidism (SHPT) is one of the most common complications of CKD, mainly manifested as parathyroid Increased PTH levels and hyperplasia of the parathyroid glands. Studies have shown that calcium-sensing receptor (CaSR) is an important link in the pathogenesis of SHPT. [0003] Cinacalcet is a calcimimetic agent developed by NPS Pharmaceuticals of the United States. On March 8, 2004, the FDA approved the marketing of cinacalcet hydrochloride produced by Amgen Company, with the product name "Sensipar". The drug is mainly used for the treatment of secondary hyperparathyroidism in patients with kidney disease on dialysis, or hypercalcemia caused by parathyroid cancer. [0004] The currently marketed cinacalcet preparations are all or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/137A61K47/10A61P3/14A61P5/20A61P13/12A61P35/00
CPCA61K31/137A61K9/0014A61K47/10A61K9/06A61P13/12A61P5/20A61P35/00A61P3/14
Inventor 王立坤张凤娥顾国祥
Owner NANJING HAIWEI PHARM TECH CO LTD
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