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A kind of small hollow gold nanorod and its preparation method and application

A gold nanorod, hollow technology, applied in the field of small hollow gold nanorods and its preparation, to achieve good pharmacokinetics, good uniformity, and high tumor enrichment effects

Active Publication Date: 2021-08-03
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are currently no methods to obtain small-sized hollow gold nanorods, and the reported gold nanorods with a size of less than 100 nanometers that have response characteristics in the second near-infrared region are all solid structures.

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  • A kind of small hollow gold nanorod and its preparation method and application
  • A kind of small hollow gold nanorod and its preparation method and application

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preparation example Construction

[0025] Such as figure 1 As shown, the embodiment of the present invention provides a preparation method of small hollow gold nanorods, the preparation method comprising the following steps:

[0026] (a) Add the tellurium precursor into the solution containing the reducing agent, fully stir the reaction at a temperature of 30°C to 50°C for 1min to 5min, then add the selenium precursor to continue the reaction for 3min to 10min, wherein the tellurium precursor and the selenium The molar ratio of the precursor is 1:1 to 1:3. After the reaction is completed, the reaction solution is diluted in a solution containing a surfactant, and after being fully stirred, solid-liquid separation is carried out to obtain a precipitate, thereby preparing tellurium selenide nanorods ;

[0027] (b) Disperse the tellurium selenide nanorods prepared in step (a) in an aqueous solution at 1°C to 25°C, add silver nitrate solution and stir for 2min to 15min, then add gold precursor to continue the reac...

Embodiment 1

[0034] (a) Add tellurium dioxide into the hydrazine hydrate solution, fully stir the reaction at 30°C for 3 minutes, then add selenous acid solution and continue the reaction for 5 minutes, wherein the molar ratio of tellurium dioxide to selenous acid is 1 : 2, after the reaction is finished, the reaction solution is diluted in a solution containing sodium lauryl sulfate, and after fully stirring, solid-liquid separation is carried out to obtain a precipitate, thereby making a tellurium selenide nanorod;

[0035](b) Disperse the tellurium-selenide nanorods prepared in step (a) in an aqueous solution at 25°C, add silver nitrate solution and stir for 2 minutes, then add gold precursors to continue the reaction for 1 minute, wherein the tellurium-selenide nanorods and gold precursors The molar ratio of silver nitrate and gold precursor is 1:1, and the molar ratio of silver nitrate and gold precursor is 1:6. Finally, add cysteine ​​and polyethylene glycol solution and react for 1mi...

Embodiment 2

[0037] (a) Add tellurous acid into hydrazine hydrate solution, fully stir the reaction at 40°C for 5 minutes, then add sodium selenite solution and continue the reaction for 10 minutes, wherein the molar ratio of tellurous acid to sodium selenite The ratio is 1:1. After the reaction is completed, the reaction solution is diluted in a solution containing sodium lauryl sulfate, and after being fully stirred, solid-liquid separation is carried out to obtain a precipitate, thereby preparing tellurium selenide nanorods;

[0038] (b) Disperse the tellurium-selenide nanorods prepared in step (a) in an aqueous solution at 10°C, add silver nitrate solution and stir for 5 minutes, then add gold precursors to continue the reaction for 6 minutes, wherein the tellurium-selenide nanorods and gold precursors The molar ratio of silver nitrate and gold precursor is 3:2, the molar ratio of silver nitrate and gold precursor is 1:3, finally add cysteine ​​and polyethylene glycol solution and react...

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Abstract

The invention belongs to the field of nanometer reagents, and specifically discloses a small hollow gold nanorod and its preparation method and application. The preparation method comprises the following steps: adding a tellurium precursor into a solution containing a reducing agent and reacting for a preset time, then adding a selenium precursor to continue the reaction for a preset time, and adding a solution containing a surfactant after the reaction is completed and fully stirring, Finally, solid-liquid separation is carried out to obtain a precipitate; the prepared tellurium selenide nanorods are dispersed in an aqueous solution, silver nitrate solution is added and reacted for a preset time, then gold precursor is added to continue the reaction for a preset time, and finally cysteine ​​and The polyethylene glycol solution is reacted for a preset time, and after the reaction is completed, solid-liquid separation is carried out to obtain a precipitate, so as to prepare small hollow gold nanorods. The invention adjusts the size of the template by stepwise reaction and controlling the reaction conditions, so that the prepared small hollow gold nanorods not only have the function of gold nanostructures, but also have the response characteristics of the second near-infrared region under the condition of smaller size.

Description

technical field [0001] The invention belongs to the field of nanometer reagents, and more specifically relates to a small hollow gold nanorod and its preparation method and application. Background technique [0002] In some diagnosis and treatment methods of tumors, the combined use of nanomaterials with special functions can greatly improve the efficiency of diagnosis and treatment. For example, photoacoustic imaging requires a nano-reagent that can produce photothermal effects in a specific wavelength range as a contrast agent. At present, the most commonly used is to use nano-reagents responding in the near-infrared region as contrast agents for photoacoustic imaging. In fact, because in living tissue, the second near-infrared region has relatively the lowest background interference, using a light source in the second near-infrared region is more conducive to obtaining stable and reliable photoacoustic signals. [0003] For the preparation of nano-reagents responding in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24B22F1/00B82Y40/00
CPCB22F9/24B82Y40/00B22F1/0549B22F1/07B22F1/0547
Inventor 翟天佑蔡凯李会巧
Owner HUAZHONG UNIV OF SCI & TECH
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