Method for inhibiting crystal change of epsilon-CL-20 crystal by catecholamine polymer and epsilon-CL-20 crystal with high crystal change resistance
A-CL-20, catecholamine technology, applied in the field of CL-20 modification, can solve the problems of complex process, limited effect of improving the crystal transformation temperature of CL-20, etc., and achieve the effect of good safety and simple operation
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Embodiment 1
[0040] (1) Weigh 0.2 g of dopamine, dissolve it in 300 mL of Tris-HCl buffer (10 mM, pH=8.5) and stir for 10 min, so that dopamine is fully dissolved in Tris-HCl buffer to obtain a dopamine solution;
[0041] (2) Weigh 19.8g of ε-CL-20 crystal material (particle size is 150~300μm), add it into the dopamine solution, stir and react at room temperature (25°C) and 180r / min for 12h, during the reaction process Observe that the color of the system changes from transparent to dark brown;
[0042] (3) The suspension obtained after the reaction was suction-filtered, the obtained solid material was washed with absolute ethanol, and then dried in an oven at 50° C. for 6 hours to obtain ε-CL-20 crystals with high crystal transformation resistance.
Embodiment 2
[0044] The ε-CL-20 crystal with high anti-crystal transformation property was prepared according to the method of Example 1, except that levodopa was used instead of dopamine.
Embodiment 3
[0046] The high crystal transformation resistance ε-CL-20 crystal was prepared according to the method of Example 1, except that 6-hydroxydopamine was used instead of dopamine.
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