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Antibacterial polymer and preparation method thereof

A polymer and weight percentage technology, applied in the polymer field, can solve the problems of hemolysis, pathogenic microorganism drug resistance, etc., and achieve the effect of strong antibacterial activity, good stability and low hemolytic activity

Inactive Publication Date: 2020-07-28
ANHUI KIWI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In recent years, due to the abuse of traditional antibiotics, the problem of drug resistance of pathogenic microorganisms has become more and more serious, and some antibiotics are highly toxic and prone to hemolysis, which poses a huge threat to human health, and there is an urgent need to develop new antibacterial drugs

Method used

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  • Antibacterial polymer and preparation method thereof
  • Antibacterial polymer and preparation method thereof
  • Antibacterial polymer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Add acetonitrile (30mL), butyl methacrylate (0.07mol), methacryloyloxyethyltrimethylammonium chloride (0.07mol), hydroxyethyl methacrylate (0.015mol) to a 50mL reaction tube in sequence and dodecylmercaptan (0.007mol), the oil bath was heated to 60°C. After the temperature stabilized for a few minutes, the initiator azobisisobutyronitrile (1.0 mmol) was dissolved in 10 mL of acetonitrile and added to the reaction for 6 h. The reaction system was washed with acetonitrile for 3 times, and the solid residue was washed with dichloromethane for 2 hours. Next, put the solid residue in a 50°C oven to dry to obtain the antibacterial polymer.

[0030] The viscosity-average molecular weight of the antibacterial macromolecule is 3000-4500, the weight percentage of methacryloyloxyethyltrimethylammonium chloride in the antibacterial macromolecule is 50%-55%, and the content of hydroxyethyl methacrylate The weight percentage is 5%-10%.

Embodiment 2

[0032] Add acetonitrile (30 mL), butyl methacrylate (0.07 mol), methacryloyloxyethyltrimethylammonium chloride (0.14 mol), hydroxyethyl methacrylate (0.015 mol) to a 50 mL reaction tube in sequence , and dodecylmercaptan (0.007mol), the oil bath was heated to 60°C. After the temperature stabilized for several minutes, the initiator azobisisobutyronitrile (1.0 mmol) was dissolved in 10 mL of acetonitrile and added to the reaction for 6 h. The reaction system was washed with acetonitrile for 3 times, the solid residue was washed twice with dichloromethane, and the solid residue was dried in an oven at 50°C to obtain the antibacterial polymer.

[0033] The viscosity-average molecular weight of the antibacterial macromolecule is 5000-6500, the weight percentage of methacryloyloxyethyltrimethylammonium chloride in the antibacterial macromolecule is 70%-75%, and the content of hydroxyethyl methacrylate The weight percentage is 2%-6%.

Embodiment 3

[0035] Add acetonitrile (30 mL), butyl methacrylate (0.07 mol), methacryloyloxyethyltrimethylammonium chloride (0.21 mol), hydroxyethyl methacrylate (0.015 mol) to a 50 mL reaction tube in sequence and dodecylmercaptan (0.007mol), the oil bath was heated to 60°C. After the temperature stabilized for several minutes, the initiator azobisisobutyronitrile (1.0 mmol) was dissolved in 10 mL of acetonitrile and added to the reaction for 6 h. The reaction system was washed with acetonitrile for 3 times, the solid residue was washed twice with dichloromethane, and the solid residue was dried in an oven at 50°C to obtain the antibacterial polymer.

[0036] The viscosity-average molecular weight of the antibacterial macromolecule is 6000-7000, the weight percentage of methacryloyloxyethyltrimethylammonium chloride in the antibacterial macromolecule is 90%-95%, and the content of hydroxyethyl methacrylate The weight percentage is 2%-6%.

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Abstract

The invention belongs to the field of macromolecules, and relates to an antibacterial polymer. a, a hydrophilic methacrylate monomer, a hydrophobic methacrylate monomer and a biocompatible unit are subjected to copolymerization to obtain a random copolymer; b, the viscosity-average molecular weight of the random copolymer is 3000-8000, and c, the weight percentage of hydrophilic methacrylate in the random copolymer is 50%-95%, and the weight percentage of a biocompatible unit is 2%-10%. The invention has the beneficial effects that the prepared antibacterial polymer has an efficient broad-spectrum antibacterial effect, has an obvious inhibition effect on staphylococcus aureus, escherichia coli, oral lactobacillus and pseudomonas aeruginosa, has very low hemolytic activity and good stability, and particularly has relatively strong antibacterial activity under an acidic condition.

Description

technical field [0001] The invention belongs to the field of polymers, and in particular relates to an antibacterial polymer and a preparation method thereof. Background technique [0002] In recent years, due to the abuse of traditional antibiotics, the problem of drug resistance of pathogenic microorganisms has become more and more serious, and some antibiotics are highly toxic and prone to hemolysis, which poses a huge threat to human health, and there is an urgent need to develop new antibacterial drugs. Contents of the invention [0003] In order to solve the above problems, the present invention provides an antibacterial polymer, which has high-efficiency broad-spectrum antibacterial effect, and has very low hemolytic activity and good stability. [0004] The present invention provides following technical scheme: [0005] An antibacterial polymer, characterized in that, [0006] a, a random copolymer obtained by copolymerizing hydrophilic methacrylate monomers, hyd...

Claims

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Application Information

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IPC IPC(8): C08F220/18C08F220/34C08F220/20A61P31/04
CPCC08F220/18C08F220/34A61P31/04Y02A50/30
Inventor 孔洪涛马秀侠乔丽君刘玲玲
Owner ANHUI KIWI BIOTECH CO LTD