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Plant monomer composition for inhibiting growth tumor cells and preparation method and application of plant monomer composition

A technology of plant monomers and tumor cells, applied in the field of medicine, can solve the problems of no specific inhibitory effect on tumor cells, low effectiveness and rate of inhibition of tumor cells, insufficient effective therapeutic concentration, etc., to achieve inhibition and killing of tumors cells, reducing tumor cell metastasis, and the effect of high-efficiency and low-toxicity treatment

Active Publication Date: 2020-07-31
陈炯
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] ① Due to the low solubility of some plant anti-tumor active ingredients (plant monomers) (such as paclitaxel and Rubescensine A, which have good anti-tumor effects), the bioavailability of the drug is extremely poor, including low absorption rate in the body and half-life time short, the effective therapeutic concentration is not enough, etc., resulting in poor anti-tumor treatment effect, which can not be practically applied in clinical practice and become a difficulty
[0006] ②The vast majority of non-targeted anti-tumor agents do not have specific inhibitory effect on tumor cells (such as anti-tumor chemotherapy drugs, untreated natural anti-tumor drugs, etc.). At the same time, it also causes damage to the normal tissues of the whole body, with side effects including strong gastrointestinal reactions, hair loss, leukopenia, etc.
[0007] ③Because tumorigenesis is the result of multiple gene mutations, the pathological mechanism is very complex, relying on a single anti-tumor drug component to attack only a certain part of the tumor cells, cannot comprehensively and effectively inhibit the growth of tumor cells, its effectiveness in inhibiting tumor cells and Relatively low inhibition rate, high recurrence and metastasis rate

Method used

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  • Plant monomer composition for inhibiting growth tumor cells and preparation method and application of plant monomer composition
  • Plant monomer composition for inhibiting growth tumor cells and preparation method and application of plant monomer composition
  • Plant monomer composition for inhibiting growth tumor cells and preparation method and application of plant monomer composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1 Preparation of a plant monomer composition and its preparation for inhibiting tumor cell growth

[0053] 1. Weigh each plant monomer according to the following parts by weight:

[0054] 20(R)-5 parts by weight of ginsenoside Rg3, 20 parts by weight of oridonin and 15 parts by weight of ganoderma polysaccharide;

[0055] 2. The above-mentioned plant monomers are freeze-dried, powdered, mixed uniformly, divided into capsules or soft capsules or compressed into tablets or made into an oil preparation.

Embodiment 2

[0056] Example 2 Preparation of a plant monomer composition and its preparation for inhibiting tumor cell growth

[0057] 1. Weigh each plant monomer according to the following parts by weight:

[0058] 20(R)-7 parts by weight of ginsenoside Rg3, 10 parts by weight of oridonin and 20 parts by weight of ganoderma polysaccharide;

[0059] 2. The above-mentioned plant monomers are freeze-dried, powdered, mixed uniformly, divided into capsules or soft capsules or compressed into tablets or made into an oil preparation.

Embodiment 3

[0060] Example 3 Preparation of a plant monomer composition and its preparation for inhibiting tumor cell growth

[0061] 1. Weigh each plant monomer according to the following parts by weight:

[0062] 20(R)-10 parts by weight of ginsenoside Rg3, 10 parts by weight of oridonin and 10 parts by weight of ganoderma polysaccharide;

[0063] 2. The above-mentioned plant monomers are freeze-dried, powdered, mixed uniformly, divided into capsules or soft capsules or compressed into tablets or made into an oil preparation.

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Abstract

The invention discloses a plant monomer composition for inhibiting growth of tumor cells and a preparation method and application of the plant monomer composition. The plant monomer composition is prepared from the following plant monomers in parts by weight: 0.1 to 10 parts of 20(R)-ginsenoside Rg3, 7 to 30 parts of oridonin and 5 to 30 parts of ganoderma lucidum polysaccharide. Preferably, the plant monomer composition is prepared from the following plant monomer-phospholipid compounds in parts by weight: 0.1 to 10 parts of a 20(R)-ginsenoside Rg3-phospholipid compound, 7 to 30 parts of an oridonin-phospholipid compound and 5 to 30 parts of ganoderma lucidum polysaccharide-phospholipid compounds. In-vitro and in-vivo tumor proliferation inhibition experiments prove that the tumor proliferation inhibition effective rate of the plant monomer composition is 100%; and the inhibition rate is 86.13%. In a word, the plant monomer composition shows a remarkable proliferation inhibition effect on the tumor, and belongs to a good medicine choice for clinically treating solid tumors.

Description

technical field [0001] The invention relates to a plant monomer composition and its preparation method and application, in particular to a plant monomer composition for inhibiting tumor cell growth, its preparation method and application. The invention belongs to the technical field of medicine. Background technique [0002] The official journal of the American Cancer Society "Journal of Cancer for Clinicians" published the "Global Cancer Statistics 2018" report online. In 2018, there are estimated to be 18.1 million new cancer cases and 9.6 million cancer deaths worldwide, which has become second only to cardiovascular diseases. the second killer of human beings. The number of new cases in my country accounted for 3.804 million cases and the number of deaths accounted for 2.296 million cases. At present, the total number of cancer patients in the country is about 5.5 million. [0003] There are many kinds of anti-tumor drugs and treatment methods in the world, including ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K31/704A61K31/352A61K47/24A61P35/00
CPCA61K9/0053A61K31/352A61K31/704A61K31/715A61K47/24A61P35/00A61K2300/00
Inventor 陈炯向廷秀
Owner 陈炯
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