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Application of Guizhi Zhonglou Xuejie Extract in the Preparation of Drugs for Adenomyosis

A technology for adenomyosis and Chonglou extract, which is applied in the field of biomedicine, can solve the problems of low cure rate and the like, and achieves the effect that the preparation method is simple and easy to implement

Active Publication Date: 2022-03-22
THE AFFILIATED HOSPITAL OF SHANDONG UNIV OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current treatment methods for this disease include drug therapy and surgical intervention, but the cure rate is low, and the choice of clinical treatment options can only be individualized based on the patient's age, symptoms and fertility requirements

Method used

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  • Application of Guizhi Zhonglou Xuejie Extract in the Preparation of Drugs for Adenomyosis
  • Application of Guizhi Zhonglou Xuejie Extract in the Preparation of Drugs for Adenomyosis
  • Application of Guizhi Zhonglou Xuejie Extract in the Preparation of Drugs for Adenomyosis

Examples

Experimental program
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preparation example Construction

[0055] Preferably, the specific steps of the preparation method are as follows: place cassia twigs in the extraction kettle, use ethyl acetate as an entrainer, and introduce CO 2 extraction under conditions to obtain an extract; place the extract in a volatile oil extractor to continue micro-boiling extraction through steam distillation to obtain a brown-yellow volatile oil, that is, the cassia twig extract.

[0056] Further preferably, the cassia twig is extracted after being coarsely crushed; on the one hand, it is beneficial to the full dissolution of the volatile oil substances in the medicinal material;

[0057] Further preferably, the extraction temperature is 38-42°C.

[0058] Further preferably, the extraction pressure is 280-320 bar.

[0059] Further preferably, the extraction time is 1.8-2.2 hours.

[0060] Further preferably, the CO 2 The flow rate is 13-17ml / min.

[0061] Further preferably, the ethyl acetate is 0.22-0.28ml / min.

[0062] Further preferably, th...

Embodiment 1

[0097] Example 1 Preparation of Cassia Twig Extract and Its Intervention Effect on Adenomyosis Ectopic Lesion Cells

[0098] 1. Preparation of Cinnamon Twig Extract

[0099] The total volatile oil extract of cassia twig was prepared by supercritical fluid extraction-steam distillation technology. Specific process route: Take 2kg of cassia twigs, coarsely crush them, put them in a 10L extraction kettle, extract them at a pressure of 300bar, at an extraction temperature of 40°C, for a dynamic extraction time of 2h, in CO 2 The flow rate is 15ml / min, and the entrainer ethyl acetate is 0.25ml / min. Take the brownish-red liquid with strong fragrance obtained from the extraction, put it in a 500ml round bottom flask, use a volatile oil extractor to extract by steam distillation for 1 hour, and separate the brownish-yellow volatile oil (65ml) to obtain the total volatile oil extract of cassia twigs.

[0100] 2. Intervention effect of cassia twig extract on ectopic lesion cells of ad...

Embodiment 2

[0107] Example 2 Preparation of Chonglou Extract and Its Intervention Effect on Adenomyosis Ectopic Lesion Cells

[0108] 1. The preparation method of the extract of Chonglou

[0109] The extract of Chonglou was prepared by alcohol extraction, water sedimentation and high-speed centrifugation. The specific process route is as follows: take 2 kg of eucalyptus, grind it into the coarsest powder, add 6 times the amount of 70% ethanol to reflux and extract three times, each time for 1.5 hours, combine the extracts, filter, and the filtrate decompresses to recover ethanol and concentrate to a relative density of about If the temperature is 1.10 (60°C), add 2 times the amount of water and stir well, let it stand for refrigerated (2-10°C) for 6 hours, centrifuge (6000r / min, 5min), take the precipitate, and dry the precipitate under reduced pressure (65-70°C, - 0.08Mpa), pulverized, that is.

[0110] 2. Intervention effect of Chonglou extract on ectopic focus cells of adenomyosis

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Abstract

The invention specifically relates to the application of the extract of cassia twigs and rhizomes in the preparation of medicines for treating adenomyosis. Aiming at the current situation that there is no specific drug for the treatment of adenomyosis and it is difficult to cure it, the purpose of the present invention is to screen the extracts with anti-adenomyosis activity from the drugs commonly used in clinical practice to promote blood circulation, remove blood stasis, soothe the liver and regulate qi. It helps to clarify the treatment mechanism of adenomyosis and provide corresponding drugs for the clinical treatment of adenomyosis. The research of the present invention provides the extracts of cinnamon twig, chrysanthemum, and jerky root, and combined extracts, and verifies that the above-mentioned extracts have an inhibitory effect on the ectopic lesion cells of adenomyosis. Further, it also provides the above-mentioned extracts that inhibit Mechanism of focal tissue. The extracts of cassia twig, chrysanthemum, japonicus and combined extracts provided by the present invention are expected to become active ingredients for the clinical treatment of adenomyosis, and are of great significance to the development of first-line therapeutic drugs.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of an extract of cassia twigs and rhizomes in the preparation of medicines for treating adenomyosis. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Adenomyosis is a diffuse or localized lesion in which endometrial glands and stroma invade the myometrium. Like endometriosis, it is a common and difficult disease in gynecology. Adenomyosis mostly occurs in multiparous women aged 30 to 50, but it can also be seen in young nulliparous women. This may be related to the increase in various uterine cavity operations, and its etiology is not completely ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/896A61P15/00
CPCA61K36/54A61K36/896A61K36/889A61P15/00A61K2236/37A61K2236/333A61K2300/00
Inventor 师伟王信刘志勇徐丽李莉牛卫品
Owner THE AFFILIATED HOSPITAL OF SHANDONG UNIV OF TCM
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