Multi-targeting fusion cell membrane modified bionic nano delivery system as well as preparation method and application thereof

A technology of biomimetic nano-delivery system, applied in the field of medicine, can solve the problems of PEGylated nano-carrier development and limited clinical application, and achieve the effect of avoiding immune clearance, promoting apoptosis and enhancing the effect

Inactive Publication Date: 2020-09-01
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This limits the development and clinica

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  • Multi-targeting fusion cell membrane modified bionic nano delivery system as well as preparation method and application thereof
  • Multi-targeting fusion cell membrane modified bionic nano delivery system as well as preparation method and application thereof
  • Multi-targeting fusion cell membrane modified bionic nano delivery system as well as preparation method and application thereof

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Embodiment 1

[0064] This embodiment provides a biomimetic nano-delivery system modified by multiple targeted fusion cell membranes, including a fusion cell membrane and a negatively charged nano-core wrapped by the fusion cell membrane; the fusion cell membrane is a cell membrane obtained by fusion of a macrophage cell membrane and a cancer cell membrane; The negatively charged nano inner core is loaded with hydrophobic drugs.

[0065] The mass ratio of the macrophage membrane to the cancer cell membrane is 1:1. The mass ratio of the fused cell membrane to the negatively charged nano-inner core carrying the hydrophobic drug is 1:1.

[0066] The hydrophobic drug is a hydrophobic chemotherapeutic drug or a hydrophobic small molecule drug.

[0067] In this embodiment, the preparation method of the multi-targeted fusion cell membrane modified biomimetic nano-delivery system includes the following steps:

[0068] Preparation of fusion cell membranes: mixing the macrophage membranes with the c...

Embodiment 2

[0072] This embodiment provides a biomimetic nano-delivery system modified by multiple targeted fusion cell membranes, including fusion cell membranes and negatively charged nano-cores wrapped by the fusion cell membranes; the fusion cell membranes are obtained by fusion of macrophage cell membranes and cancer cell membranes; the The negatively charged nanocores are loaded with hydrophobic drugs.

[0073] The mass ratio of the fused cell membrane to the negatively charged nano-core loaded with hydrophobic drugs is 1:1. The mass ratio of the macrophage membrane to the cancer cell membrane is 1:1.

[0074] The hydrophobic drug is a hydrophobic chemotherapeutic drug. The hydrophobic chemotherapeutic drug is fat-soluble doxorubicin.

[0075] In this embodiment, the material of the negatively charged nano core is PLGA (polylactic acid-glycolic acid copolymer).

[0076] In this embodiment, the cancer cell membrane is breast cancer cell membrane.

[0077] In this embodiment, the ...

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Abstract

The invention discloses a multi-targeting fusion cell membrane modified bionic nano delivery system as well as a preparation method and application thereof. The multi-targeting fusion cell membrane modified bionic nano delivery system comprises a fusion cell membrane and a negative electricity nano core wrapped by the fusion cell membrane, wherein the fusion cell membrane is obtained by fusing a macrophage membrane and a cancer cell membrane; and the negative electricity nano core carries a hydrophobic drug. The surface of the fusion cell membrane contains proteins on the surfaces of a macrophage membrane and a cancer cell membrane, so that the fusion cell membrane has a targeted adhesion recognition function, and a modified nano drug loading system is endowed with a multiple tumor targeting function. The fusion cell membrane modified bionic nano delivery system can deliver chemotherapeutic drugs, has the characteristics of good stability, low immunogenicity and good biocompatibility,and provides an effective means for hydrophobic therapeutic drug delivery in tumor targeted therapy.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a multi-target fusion cell membrane modified biomimetic nano-delivery system and its preparation method and application. Background technique [0002] Tens of millions of people die from various cancers every year in the world. It is hoped that nanocarriers can be used to selectively inhibit tumor growth by targeting tumor sites. However, the drug release process of nano-drug carriers from intravenous injection into cancer cells is relatively complicated, and there are various obstacles such as macrophage phagocytosis, cancer cell membrane penetration, endosome / lysosome escape, etc., resulting in affected treatment results. Although various nano-drug carriers have been reported at home and abroad, it is still a severe challenge to study nano-drug carriers with clinical application prospects. [0003] The rapid clearance of the systemic circulation and immune system has been pro...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K47/46A61K31/337A61K31/405A61K31/675A61K31/704A61P35/00C12N5/0786C12N5/09
CPCA61K9/5068A61K9/5089A61K31/704A61K31/337A61K31/675A61K31/405A61P35/00C12N5/0693C12N5/0645C12N2509/00C12N2509/10
Inventor 原永芳宫春爱韩璐俞晓燕王彧杰王蓉
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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