Technetium [99mTc] carbon microsphere injection and preparation method and application thereof

Abstract

The invention discloses a technetium [99mTc] carbon microsphere injection. The injection comprises carbon microspheres and a radionuclide technetium [99mTc] adsorbed in the carbon microspheres, wherein every 1 ml of the injection contains 0.5-200 mg of the carbon microspheres, and the technetium activity of the radionuclide technetium [99mTc] is 0.1-100 mCi. The preparation method comprises the step of mixing a sterile pertechnetium acid radical (99mTcO4 <->) solution with carbon microsphere dry powder or a carbon microsphere suspension. The injection is high in labeling rate, low in release rate and simple in preparation method, the major problem that radiopharmaceuticals with a short half-life period are prone to decay and lose efficacy or radionuclide loses greatly is solved, and a brand-new imaging agent is provided for SPECT diagnosis.

Description

technical field [0001] The invention relates to the technical field of single photon emission computed tomography (SPECT) imaging agents, in particular to a technetium[ 99m Tc] charcoal microsphere injection and its preparation method and application. Background technique [0002] Technetium [ 99m Tc] is an ideal medical tracer nuclide, the most commonly used imaging nuclide in nuclear medicine, and occupies a dominant position in diagnostic imaging. Technetium [ 99m The gamma ray energy released by Tc] is about 140KeV, and the half-life is about 6.1 hours, which is very suitable as an imaging agent for single photon emission computed tomography. Among the existing medical radionuclide imaging agents, more than 80% are technetium[ 99m Tc] labeled radiopharmaceuticals, mainly technetium [ 99m Tc]-labeled organic molecules, these drugs can be used for imaging of brain, myocardium, tumor, liver, lung, spleen, bone, etc. But in general technetium[ 99m There are few types ...

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Problems solved by technology

This preparation method has problems such as relatively complicated process route and long time-consuming, and is suitable for producing radioactive microsphere products with long half-life nuclides in GMP production workshops, and the nuclide technetium [ 99m Tc] has a half-life of 6.02 hours, and technetium [ 99m The chemical properties of Tc] are also similar to that of iodine [ 131 I] and Yttrium [ 90 Y] There is an obvious difference, the above process route is not suitable for technetium [ 99m Preparation of Tc]-labeled carbon microspheres

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