Micro-unit assembling system and method based on magnetic control micro-fiber array
An assembly system and microfiber technology, applied in the direction of human tubular structure devices, blood vessels, etc., can solve the problems of low success rate and inflexibility, and achieve the effect of avoiding adhesion, strong superiority, and avoiding damage
Active Publication Date: 2020-09-08
BEIJING INSTITUTE OF TECHNOLOGYGY
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Problems solved by technology
[0005] In view of this, the object of the present invention is to provide a micro-unit assembly system and method based on magnetically controlled microfiber arrays, which can effectively solve the problems of low success rate and inflexibility in the micro-assembly process of microvascular two-dimensional ring units at the present stage
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[0031] The present invention will be described in detail below with reference to the accompanying drawings and examples.
[0032] The present invention is realized by the following devices, including base, electromagnetic coil A, electromagnetic coil B, microscope and visual system, electromagnetic coil C, electromagnetic coil D, liquid delivery tube A, liquid delivery tube B, culture dish, and liquid delivery tube C , liquid delivery tube D, microvascular two-dimensional annular unit, magnetic manipulator, and liquid discharge tube. The square petri dish is located at the center of the mounting platform, and electromagnetic coil A, electromagnetic coil B, electromagnetic coil C, and electromagnetic coil D surround the petri dish, facing four sides of the petri dish respectively. The microscope and vision system are located directly above the culture dish, and are used to detect the state of the magnetic manipulator and the microvascular two-dimensional ring unit in the cultur...
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The invention provides a micro-unit assembling system and method based on a magnetic control micro-fiber array. A culture solution containing capillary two-dimensional annular units is dropped from the top of a culture dish in sequence, and the bending position of a magnetic manipulator is controlled by changing the magnetic field intensity of a pair of orthogonal electromagnets according to judgment of a microscope and a visual system, so that automatic assembly of capillaries is realized. According to the invention, a release process of an operation target does not exist, the adhesive forcebetween microscopic objects is avoided to a great extent, the grabbing success rate and the grabbing efficiency are greatly improved, and damage to the capillary two-dimensional annular units is avoided; compared with an existing capillary assembling mode in a micro-fluidic chip, the method is not limited by operation tasks and the sizes of the capillaries, and operation flexibility is high; and the micro-unit assembling method based on the magnetic control micro-fiber array and provided by the invention shows very strong superiority in the assembling operation of the capillary two-dimensionalannular units.
Description
technical field [0001] The invention belongs to the technical field of micro-nano operation and micro-assembly, and in particular relates to a micro-unit assembly system and method based on a magnetically controlled micro-fiber array. Background technique [0002] In today's society, tissue damage and organ failure are one of the important factors threatening human health. With the development of tissue engineering, more and more people have found that the replacement of damaged parts by constructing artificial tissues and organs is an important way to solve this problem. However, due to the lack of a blood circulation system, the interior of many artificial tissues and organs is particularly prone to insufficient nutrition and oxygen supply. At the same time, according to the diffusion effect of molecules, the maximum distance that artificially cultivated tissue cells can actively absorb nutrients is 200 μm. Therefore, it is extremely important to quickly cultivate and co...
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Login to View More IPC IPC(8): A61F2/06
CPCA61F2/06
Inventor 刘晓明李玉洋黄强新井健生
Owner BEIJING INSTITUTE OF TECHNOLOGYGY